Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51F1 Gene

Aliases for OR51F1 Gene

  • Olfactory Receptor Family 51 Subfamily F Member 1 2 3 5
  • Olfactory Receptor 51F1 3 4
  • OR51F1P 3 4
  • Olfactory Receptor, Family 51, Subfamily F, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 51 Subfamily F Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 51, Subfamily F, Member 1 Pseudogene 3
  • Olfactory Receptor OR11-21 Pseudogene 3
  • OR11-21 3
  • OR51F1 5

External Ids for OR51F1 Gene

Previous HGNC Symbols for OR51F1 Gene

  • OR51F1P

Previous GeneCards Identifiers for OR51F1 Gene

  • GC11M004756
  • GC11M004746

Summaries for OR51F1 Gene

Entrez Gene Summary for OR51F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR51F1 Gene

OR51F1 (Olfactory Receptor Family 51 Subfamily F Member 1) is a Protein Coding gene. Diseases associated with OR51F1 include Malaria. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11A1.

UniProtKB/Swiss-Prot Summary for OR51F1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51F1 Gene

Genomics for OR51F1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51F1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004493 Enhancer 0.9 FANTOM5 ENCODE 8.6 +276.8 276784 0.5 ZNF654 YY1 CTCF REST TRIM22 RAD51 RAD21 SMC3 EBF1 BHLHE40 OR52K2 OR52B4 TRIM21 OR51F1 OR52K1 OR52M2P OR52M1 lnc-OR52K2-1
GH11J004658 Enhancer 0.7 Ensembl 9.5 +110.8 110838 0.6 NCOR1 IKZF1 ZNF592 NFIC TAL1 PRDM10 SMARCA4 FOXM1 HDAC2 TCF12 lnc-OR51E1-1 OR51E2 OR51F1 OR51E1 OR51A9P
GH11J004647 Enhancer 0.3 Ensembl 9.8 +122.5 122537 0.4 ATF2 JUN OR51F2 OR51E2 TRIM68 OR51F1 C11orf40 OR51E1 lnc-OR51E1-1
GH11J004492 Enhancer 0.2 FANTOM5 14.5 +277.5 277522 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11J004627 Enhancer 0.3 Ensembl 9.3 +142.3 142337 1.6 CTCF OR51F2 OR52I2 C11orf40 OR51F1 OR52B4 TRIM68 HSALNG0082351 lnc-OR51D1-1 OR51D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51F1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51F1

Top Transcription factor binding sites by QIAGEN in the OR51F1 gene promoter:
  • HSF1 (long)
  • HSF1short
  • HSF2
  • Ik-3
  • Nkx6-1
  • RP58

Genomic Locations for OR51F1 Gene

Latest Assembly
chr11:4,768,979-4,769,938
(GRCh38/hg38)
Size:
960 bases
Orientation:
Minus strand

Previous Assembly
chr11:4,790,209-4,791,168
(GRCh37/hg19 by Entrez Gene)
Size:
960 bases
Orientation:
Minus strand

Genomic View for OR51F1 Gene

Genes around OR51F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51F1 Gene

Proteins for OR51F1 Gene

  • Protein details for OR51F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGY5-O51F1_HUMAN
    Recommended name:
    Olfactory receptor 51F1
    Protein Accession:
    A6NGY5

    Protein attributes for OR51F1 Gene

    Size:
    319 amino acids
    Molecular mass:
    35849 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51F1 Gene

Post-translational modifications for OR51F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51F1 Gene

Domains & Families for OR51F1 Gene

Gene Families for OR51F1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51F1 Gene

Suggested Antigen Peptide Sequences for OR51F1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 51F1 (O51F1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NGY5

UniProtKB/Swiss-Prot:

O51F1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51F1: view

Function for OR51F1 Gene

Molecular function for OR51F1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51F1 Gene

Gene Ontology (GO) - Molecular Function for OR51F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR51F1: view
genes like me logo Genes that share phenotypes with OR51F1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51F1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51F1 Gene

Localization for OR51F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51F1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51F1 Gene

Pathways & Interactions for OR51F1 Gene

genes like me logo Genes that share pathways with OR51F1: view

Pathways by source for OR51F1 Gene

Interacting Proteins for OR51F1 Gene

Gene Ontology (GO) - Biological Process for OR51F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51F1: view

No data available for SIGNOR curated interactions for OR51F1 Gene

Drugs & Compounds for OR51F1 Gene

No Compound Related Data Available

Transcripts for OR51F1 Gene

mRNA/cDNA for OR51F1 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51F1

Alternative Splicing Database (ASD) splice patterns (SP) for OR51F1 Gene

No ASD Table

Relevant External Links for OR51F1 Gene

GeneLoc Exon Structure for
OR51F1

Expression for OR51F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51F1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51F1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51F1

SOURCE GeneReport for Unigene cluster for OR51F1 Gene:

Hs.553659
genes like me logo Genes that share expression patterns with OR51F1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51F1 Gene

Orthologs for OR51F1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51F1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466349 29
  • 98.18 (n)
Cow
(Bos Taurus)
Mammalia LOC507882 29
  • 85.15 (n)
Dog
(Canis familiaris)
Mammalia LOC100684107 29
  • 84.96 (n)
Rat
(Rattus norvegicus)
Mammalia LOC684170 29
  • 82.32 (n)
Mouse
(Mus musculus)
Mammalia Or51f1 45 Olfr566
  • chr7:102,856,324-102,857,280
Or51f14 45 Olfr583
  • chr7:103,051,300-103,052,256
Or51f15 45 Olfr585
  • chr7:103,097,743-103,098,696
Species where no ortholog for OR51F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR51F1 Gene

ENSEMBL:
Gene Tree for OR51F1 (if available)
TreeFam:
Gene Tree for OR51F1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51F1: view image
Alliance of Genome Resources:
Additional Orthologs for OR51F1

Paralogs for OR51F1 Gene

(358) SIMAP similar genes for OR51F1 Gene using alignment to 2 proteins:

  • O51F1_HUMAN
  • A6NLW9_HUMAN

Pseudogenes.org Pseudogenes for OR51F1 Gene

genes like me logo Genes that share paralogs with OR51F1: view

Variants for OR51F1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR51F1 Gene

O51F1_HUMAN-A6NGY5
A single nucleotide deletion at position Arg-92 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in non-Africans.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51F1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs34672924 Benign: not specified 4,769,643(-) CG/C
NM_001004752.2(OR51F1):c.295del (p.Arg99fs)
FRAMESHIFT
rs1030723 -- p.Ser233Phe
rs1030726 -- p.Asp301Tyr
rs11033793 -- p.His232Arg
rs11033800 -- p.Arg74Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR51F1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR51F1 Gene

Variant ID Type Subtype PubMed ID
esv29053 CNV loss 19812545
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv553175 CNV loss 21841781
nsv832056 CNV gain 17160897

Variation tolerance for OR51F1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.33; 99.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51F1
Leiden Open Variation Database (LOVD)
OR51F1

SNP Genotyping and Copy Number Assays for research

Disorders for OR51F1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR51F1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
malaria
  • malaria, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR51F1

genes like me logo Genes that share disorders with OR51F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51F1 Gene

Publications for OR51F1 Gene

  1. Imputation-based meta-analysis of severe malaria in three African populations. (PMID: 23717212) Band G … Malaria Genomic Epidemiological Network (PLoS genetics 2013) 3
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3

Products for OR51F1 Gene

Sources for OR51F1 Gene