Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51D1 Gene

Aliases for OR51D1 Gene

  • Olfactory Receptor Family 51 Subfamily D Member 1 2 3 5
  • Olfactory Receptor OR11-14 3 4
  • Olfactory Receptor 51D1 3 4
  • OR51D1Q 2 3
  • Olfactory Receptor, Family 51, Subfamily D, Member 1 2
  • OR11-14 3
  • OR51D1 5

External Ids for OR51D1 Gene

Previous GeneCards Identifiers for OR51D1 Gene

  • GC11U990520
  • GC11P004627
  • GC11P004616

Summaries for OR51D1 Gene

Entrez Gene Summary for OR51D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51D1 Gene

OR51D1 (Olfactory Receptor Family 51 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot Summary for OR51D1 Gene

Gene Wiki entry for OR51D1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51D1 Gene

Genomics for OR51D1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004636 Enhancer 0.7 ENCODE 250.7 -0.4 -411 0.2 ZNF654 MYC ZBTB10 CTCF REST TRIM22 RAD21 IRF4 SMC3 YY1 OR51D1 TRIM68 OR52M1 HSALNG0082351
GH11J004606 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 -28.6 -28645 4.1 SP1 ZNF207 IKZF1 ZNF600 POLR2A ZNF10 NFIC YY1 SMAD5 MBD2 TRIM68 lnc-C11orf40-2 RRM1 NUP98 OR51D1 OR51E1 piR-39858-065
GH11J004682 Enhancer 0.3 Ensembl ENCODE 11.2 +45.8 45807 1.4 OR51E1 OR51D1 PGAP2 OR51C1P OR51E2 LOC105376528
GH11J004672 Enhancer 0.2 Ensembl 11 +35.1 35124 0.8 OR51E1 OR51D1 OR51E2 OR51A9P OR51F1 TRIM68 LOC105376528 lnc-OR51E1-1 OR51C1P
GH11J004480 Enhancer 0.9 FANTOM5 Ensembl ENCODE 1.8 -155.0 -155023 4.9 ZNF316 NFE2 JUND MYNN SPI1 ZFP69B DPF2 ATF3 ZNF692 FOS OR52K1 OR52K3P TRIM68 TRIM21 OR51F2 OR52K2 OR51D1 OR51T1 OR51G1 lnc-OR52K2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51D1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51D1

Top Transcription factor binding sites by QIAGEN in the OR51D1 gene promoter:
  • AML1a
  • Brachyury
  • C/EBPalpha
  • E47
  • Evi-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Tal-1beta

Genomic Locations for OR51D1 Gene

Latest Assembly
chr11:4,637,477-4,643,060
(GRCh38/hg38)
Size:
5,584 bases
Orientation:
Plus strand

Previous Assembly
chr11:4,658,707-4,664,290
(GRCh37/hg19 by Entrez Gene)
Size:
5,584 bases
Orientation:
Plus strand

chr11:4,660,945-4,662,068
(GRCh37/hg19 by Ensembl)
Size:
1,124 bases
Orientation:
Plus strand

Genomic View for OR51D1 Gene

Genes around OR51D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51D1 Gene

Proteins for OR51D1 Gene

  • Protein details for OR51D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF3-O51D1_HUMAN
    Recommended name:
    Olfactory receptor 51D1
    Protein Accession:
    Q8NGF3
    Secondary Accessions:
    • B9EIK4

    Protein attributes for OR51D1 Gene

    Size:
    324 amino acids
    Molecular mass:
    35839 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51D1 Gene

Post-translational modifications for OR51D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51D1 Gene

Domains & Families for OR51D1 Gene

Gene Families for OR51D1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51D1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR51D1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-14 (O51D1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGF3

UniProtKB/Swiss-Prot:

O51D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51D1: view

Function for OR51D1 Gene

Molecular function for OR51D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51D1 Gene

Gene Ontology (GO) - Molecular Function for OR51D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR51D1: view
genes like me logo Genes that share phenotypes with OR51D1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51D1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51D1 Gene

Localization for OR51D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51D1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51D1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51D1 Gene

Pathways & Interactions for OR51D1 Gene

genes like me logo Genes that share pathways with OR51D1: view

Pathways by source for OR51D1 Gene

Interacting Proteins for OR51D1 Gene

Gene Ontology (GO) - Biological Process for OR51D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51D1: view

No data available for SIGNOR curated interactions for OR51D1 Gene

Drugs & Compounds for OR51D1 Gene

No Compound Related Data Available

Transcripts for OR51D1 Gene

mRNA/cDNA for OR51D1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51D1

Alternative Splicing Database (ASD) splice patterns (SP) for OR51D1 Gene

No ASD Table

Relevant External Links for OR51D1 Gene

GeneLoc Exon Structure for
OR51D1

Expression for OR51D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51D1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51D1

SOURCE GeneReport for Unigene cluster for OR51D1 Gene:

Hs.553728
genes like me logo Genes that share expression patterns with OR51D1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51D1 Gene

Orthologs for OR51D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51D1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100614707 29
  • 98.87 (n)
OR51D1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR51D1 30
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC684208 29
  • 86.29 (n)
Mouse
(Mus musculus)
Mammalia Or51d1 45 Olfr557 29 16 30
  • 86.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR51D1 30
  • 85 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR51D1 30
  • 81 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 30
  • 29 (a)
ManyToMany
or112-1 30
  • 27 (a)
ManyToMany
Species where no ortholog for OR51D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR51D1 Gene

ENSEMBL:
Gene Tree for OR51D1 (if available)
TreeFam:
Gene Tree for OR51D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51D1: view image
Alliance of Genome Resources:
Additional Orthologs for OR51D1

Paralogs for OR51D1 Gene

(404) SIMAP similar genes for OR51D1 Gene using alignment to 1 proteins:

  • O51D1_HUMAN
genes like me logo Genes that share paralogs with OR51D1: view

Variants for OR51D1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51D1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs905871 -- p.Ile89Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR51D1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR51D1 Gene

Variant ID Type Subtype PubMed ID
dgv1025n100 CNV loss 25217958
dgv1586n54 CNV loss 21841781
nsv1041633 CNV gain 25217958
nsv1054705 CNV loss 25217958
nsv1054847 CNV gain 25217958
nsv832055 CNV loss 17160897

Variation tolerance for OR51D1 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51D1
Leiden Open Variation Database (LOVD)
OR51D1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51D1 Gene

Disorders for OR51D1 Gene

Additional Disease Information for OR51D1

No disorders were found for OR51D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51D1 Gene

Publications for OR51D1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti WB … O'Dowd BF (Biochemical and biophysical research communications 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR51D1 Gene

Sources for OR51D1 Gene