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Aliases for OR51B6 Gene

Aliases for OR51B6 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 6 2 3 5
  • Odorant Receptor HOR5beta6 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 6 2
  • Olfactory Receptor 51B5 3
  • Olfactory Receptor 51B6 3
  • HOR5Beta6 3

External Ids for OR51B6 Gene

Previous GeneCards Identifiers for OR51B6 Gene

  • GC00U903063
  • GC11P005338
  • GC11P005301
  • GC11P005372

Summaries for OR51B6 Gene

Entrez Gene Summary for OR51B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B6 Gene

OR51B6 (Olfactory Receptor Family 51 Subfamily B Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B5.

UniProtKB/Swiss-Prot for OR51B6 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B6 Gene

Additional gene information for OR51B6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B6 Gene

Genomics for OR51B6 Gene

GeneHancer (GH) Regulatory Elements for OR51B6 Gene

Promoters and enhancers for OR51B6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005546 Enhancer 0.2 FANTOM5 7.7 +194.7 194738 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J005328 Enhancer 0.2 FANTOM5 1.9 -22.3 -22330 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
GH11J005345 Promoter 0.6 EPDnew 0.4 -5.5 -5545 0.1 FOSL1 HBE1 OR51B5 OR51B6 OR51B8P HBG2 GC11P005064 ENSG00000239920
GH11J005342 Enhancer 0.5 ENCODE 0.4 -7.8 -7812 1.9 JUN IKZF1 FOS DPF2 IKZF2 EP300 RELA OR51B5 OR51B6 OR51B8P HBE1 HBG2 GC11P005064 ENSG00000239920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51B6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR51B6 gene promoter:
  • LCR-F1
  • AML1a
  • Max1
  • c-Myc
  • GATA-3
  • GATA-2
  • GATA-1
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for OR51B6 Gene

Genomic Locations for OR51B6 Gene
939 bases
Plus strand
939 bases
Plus strand

Genomic View for OR51B6 Gene

Genes around OR51B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B6 Gene

Proteins for OR51B6 Gene

  • Protein details for OR51B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 51B6
    Protein Accession:

    Protein attributes for OR51B6 Gene

    312 amino acids
    Molecular mass:
    35269 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B6 Gene

Post-translational modifications for OR51B6 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51B6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B6 Gene

Domains & Families for OR51B6 Gene

Gene Families for OR51B6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51B6 Gene


Suggested Antigen Peptide Sequences for OR51B6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B6: view

Function for OR51B6 Gene

Molecular function for OR51B6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51B6: view
genes like me logo Genes that share phenotypes with OR51B6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51B6 Gene

Localization for OR51B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51B6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51B6 Gene

Pathways & Interactions for OR51B6 Gene

genes like me logo Genes that share pathways with OR51B6: view

Pathways by source for OR51B6 Gene

Interacting Proteins for OR51B6 Gene

Gene Ontology (GO) - Biological Process for OR51B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B6: view

No data available for SIGNOR curated interactions for OR51B6 Gene

Drugs & Compounds for OR51B6 Gene

No Compound Related Data Available

Transcripts for OR51B6 Gene

mRNA/cDNA for OR51B6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51B6 Gene

Olfactory receptor, family 51, subfamily B, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B6 Gene

No ASD Table

Relevant External Links for OR51B6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR51B6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51B6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51B6 Gene:


SOURCE GeneReport for Unigene cluster for OR51B6 Gene:

genes like me logo Genes that share expression patterns with OR51B6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51B6 Gene

Orthologs for OR51B6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466375 33
  • 98.18 (n)
OR51B6 34
  • 94 (a)
(Canis familiaris)
Mammalia OR51B6 34
  • 87 (a)
LOC100683227 33
  • 77.14 (n)
(Mus musculus)
Mammalia Or51b6 51 Olfr65 16 34 33
  • 84.83 (n)
Or51b6b 51 Olfr623 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Olr132 33
  • 84.72 (n)
(Monodelphis domestica)
Mammalia OR51B6 34
  • 80 (a)
(Bos Taurus)
Mammalia -- 34
  • 51 (a)
(Gallus gallus)
Aves -- 34
  • 45 (a)
Species where no ortholog for OR51B6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B6 Gene

Gene Tree for OR51B6 (if available)
Gene Tree for OR51B6 (if available)
Evolutionary constrained regions (ECRs) for OR51B6: view image

Paralogs for OR51B6 Gene

Paralogs for OR51B6 Gene

(359) SIMAP similar genes for OR51B6 Gene using alignment to 1 proteins:

  • O51B6_HUMAN
genes like me logo Genes that share paralogs with OR51B6: view

Variants for OR51B6 Gene

Sequence variations from dbSNP and Humsavar for OR51B6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000957365 -- 5,350,775(+) G/C upstream_transcript_variant
rs1001630819 -- 5,352,760(+) ACACATACATATACACA/ACACA downstream_transcript_variant
rs1001631269 -- 5,351,031(+) G/A upstream_transcript_variant
rs1002683126 -- 5,350,427(+) A/G upstream_transcript_variant
rs1004183604 -- 5,350,008(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR51B6 Gene

Variant ID Type Subtype PubMed ID
dgv56n21 CNV loss 19592680
esv26010 CNV gain 19812545
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv524400 CNV loss 19592680

Variation tolerance for OR51B6 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 26.38; 99.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51B6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51B6 Gene

Disorders for OR51B6 Gene

Additional Disease Information for OR51B6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR51B6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51B6 Gene

Publications for OR51B6 Gene

  1. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. (PMID: 20018918) Solovieff N … Steinberg MH (Blood 2010) 3 44 58
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M … von Doorninck JH (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR51B6 Gene

Sources for OR51B6 Gene

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