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Aliases for OR51B5 Gene

Aliases for OR51B5 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 5 2 3 5
  • Odorant Receptor HOR5'Beta5 3 4
  • Olfactory Receptor OR11-37 3 4
  • Olfactory Receptor 51B5 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 5 2
  • HOR5'Beta5 3
  • OR11-37 3

External Ids for OR51B5 Gene

Previous GeneCards Identifiers for OR51B5 Gene

  • GC00U903062
  • GC11U900610
  • GC11M005321
  • GC11M005323
  • GC11M005363

Summaries for OR51B5 Gene

Entrez Gene Summary for OR51B5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B5 Gene

OR51B5 (Olfactory Receptor Family 51 Subfamily B Member 5) is a Protein Coding gene. Diseases associated with OR51B5 include Sickle Cell Anemia. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.

UniProtKB/Swiss-Prot for OR51B5 Gene

Gene Wiki entry for OR51B5 Gene

Additional gene information for OR51B5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B5 Gene

Genomics for OR51B5 Gene

GeneHancer (GH) Regulatory Elements for OR51B5 Gene

Promoters and enhancers for OR51B5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005504 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 600.7 +0.7 722 2.7 ZFX CC2D1A CBFA2T2 MLLT1 GTF2F1 CSDE1 TRIM24 EGR1 SMARCA4 DPF2 HBE1 HBG2 OR51B5 DNHD1 UBQLNL FAM160A2 OR52D1 ENSG00000239920
GH11J005361 Enhancer 0.9 Ensembl ENCODE 19.2 +140.1 140119 7.4 CC2D1A ZNF148 MLLT1 MAFK CAVIN1 ZNF512 ZNF740 ZNF316 JUN NFE2 OR51B5 ENSG00000224091 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 ENSG00000236248
GH11J005284 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.7 +220.3 220272 2.8 CC2D1A CBFA2T2 TRIM24 DPF2 IKZF1 ZNF24 MTA2 ZNF316 EP300 MGA GC11M005293 HBBP1 HBD HBB ENSG00000224091 ENSG00000221031 OR51V1 HBG1 OR51B5 OR51AB1P
GH11J005380 Enhancer 0.6 Ensembl 16.5 +124.7 124651 0.4 CTCF RAD21 REST CBFB RUNX3 SMC3 ZNF654 ZNF143 OR51B5 OR51V1 HBB OR51M1 GC11P005378 HBG2 HBE1 ENSG00000239920 GC11P005064
GH11J005369 Enhancer 0.6 Ensembl 16.4 +135.8 135751 0.2 CTCF MAFK RAD21 REST ATF7 SMC3 ATF2 MAFF OR51B5 ENSG00000224091 OR51J1 HBB ENSG00000221031 OR51V1 GC11P005378 ENSG00000236248 HBG2 HBE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51B5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR51B5 gene promoter:
  • AML1a
  • c-Myc
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1
  • Max1
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for OR51B5 Gene

Genomic Locations for OR51B5 Gene
202,209 bases
Minus strand
6,028 bases
Minus strand

Genomic View for OR51B5 Gene

Genes around OR51B5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B5 Gene

Proteins for OR51B5 Gene

  • Protein details for OR51B5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 51B5
    Protein Accession:
    Secondary Accessions:
    • B2RN59

    Protein attributes for OR51B5 Gene

    312 amino acids
    Molecular mass:
    35241 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B5 Gene

Post-translational modifications for OR51B5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR51B5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B5 Gene

Domains & Families for OR51B5 Gene

Gene Families for OR51B5 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51B5 Gene

Suggested Antigen Peptide Sequences for OR51B5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-37 (O51B5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B5: view

Function for OR51B5 Gene

Molecular function for OR51B5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51B5 Gene

Gene Ontology (GO) - Molecular Function for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,NAS 11121057
genes like me logo Genes that share ontologies with OR51B5: view
genes like me logo Genes that share phenotypes with OR51B5: view

Animal Model Products

CRISPR Products

miRNA for OR51B5 Gene

miRTarBase miRNAs that target OR51B5

Clone Products

  • Applied Biological Materials (abm): Clones for OR51B5 - Now 50% OFF >
  • * OR51B5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR51B5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR51B5 Gene

Localization for OR51B5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51B5 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 11121057
genes like me logo Genes that share ontologies with OR51B5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51B5 Gene

Pathways & Interactions for OR51B5 Gene

genes like me logo Genes that share pathways with OR51B5: view

Pathways by source for OR51B5 Gene

Interacting Proteins for OR51B5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
Selected Interacting proteins: ENSP00000300773 Q9H339-O51B5_HUMAN for OR51B5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR51B5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS,IEA 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B5: view

No data available for SIGNOR curated interactions for OR51B5 Gene

Drugs & Compounds for OR51B5 Gene

No Compound Related Data Available

Transcripts for OR51B5 Gene

mRNA/cDNA for OR51B5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR51B5 Gene

Olfactory receptor, family 51, subfamily B, member 5:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR51B5 - Now 50% OFF >
  • * OR51B5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR51B5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B5 Gene

No ASD Table

Relevant External Links for OR51B5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR51B5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51B5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51B5 Gene

This gene is overexpressed in Ovary (x4.8) and Testis (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of OR51B5 Gene:


SOURCE GeneReport for Unigene cluster for OR51B5 Gene:


Evidence on tissue expression from TISSUES for OR51B5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR51B5: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51B5 Gene

Orthologs for OR51B5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51B5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC450980 34
  • 98.61 (n)
(Canis familiaris)
Mammalia LOC100684132 34
  • 72.02 (n)
Species where no ortholog for OR51B5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B5 Gene

Gene Tree for OR51B5 (if available)
Gene Tree for OR51B5 (if available)
Evolutionary constrained regions (ECRs) for OR51B5: view image

Paralogs for OR51B5 Gene

(430) SIMAP similar genes for OR51B5 Gene using alignment to 1 proteins:

  • O51B5_HUMAN
genes like me logo Genes that share paralogs with OR51B5: view

Variants for OR51B5 Gene

Sequence variations from dbSNP and Humsavar for OR51B5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010015 -- 5,365,163(-) T/C intron_variant
rs1000021362 -- 5,359,759(-) G/A intron_variant
rs1000026548 -- 5,359,901(-) C/G intron_variant
rs1000034489 -- 5,434,892(-) C/A intron_variant
rs1000047262 -- 5,382,549(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR51B5 Gene

Variant ID Type Subtype PubMed ID
dgv1042n100 CNV gain 25217958
dgv1043n100 CNV loss 25217958
dgv1598n54 CNV loss 21841781
dgv1599n54 CNV loss 21841781
dgv1600n54 CNV loss 21841781
dgv1601n54 CNV loss 21841781
dgv1602n54 CNV loss 21841781
dgv1603n54 CNV loss 21841781
dgv195n67 CNV loss 20364138
dgv310e212 CNV loss 25503493
dgv311e212 CNV loss 25503493
dgv56n21 CNV loss 19592680
esv21699 CNV loss 19812545
esv22160 CNV loss 19812545
esv26010 CNV gain 19812545
esv2660728 CNV deletion 23128226
esv2664205 CNV deletion 23128226
esv2676206 CNV deletion 23128226
esv2744060 CNV deletion 23290073
esv2744061 CNV deletion 23290073
esv2744062 CNV deletion 23290073
esv2759800 CNV loss 17122850
esv2761646 CNV loss 21179565
esv2761647 CNV loss 21179565
esv2761648 CNV loss 21179565
esv2762893 CNV loss 21179565
esv3258941 CNV deletion 24192839
esv3337098 CNV duplication 20981092
esv3428467 CNV insertion 20981092
esv3431009 CNV duplication 20981092
esv34391 CNV loss 17911159
esv3547253 CNV deletion 23714750
esv3625225 CNV loss 21293372
esv3625226 CNV loss 21293372
esv3625227 CNV loss 21293372
esv3625228 CNV loss 21293372
esv3625229 CNV gain 21293372
esv3625230 CNV loss 21293372
esv3625231 CNV loss 21293372
esv3625232 CNV loss 21293372
esv3625234 CNV loss 21293372
esv4563 CNV loss 18987735
esv9420 CNV loss 19470904
esv997323 CNV gain 20482838
nsv1039047 CNV gain 25217958
nsv1043028 CNV gain 25217958
nsv1044243 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1047754 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv1113355 CNV deletion 24896259
nsv442597 CNV loss 18776908
nsv467669 CNV gain 19166990
nsv471745 CNV loss 16327809
nsv510997 OTHER complex 20534489
nsv514621 CNV loss 21397061
nsv521722 CNV gain 19592680
nsv524400 CNV loss 19592680
nsv553235 CNV loss 21841781
nsv553239 CNV gain 21841781
nsv553240 CNV loss 21841781
nsv553241 CNV gain 21841781
nsv553243 CNV loss 21841781
nsv553253 CNV loss 21841781
nsv832057 CNV loss 17160897

Variation tolerance for OR51B5 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.00; 98.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51B5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51B5 Gene

Disorders for OR51B5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR51B5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sickle cell anemia
  • drepanocytosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR51B5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OR51B5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51B5 Gene

Publications for OR51B5 Gene

  1. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. (PMID: 20018918) Solovieff N … Steinberg MH (Blood 2010) 3 45 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  4. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. (PMID: 27315375) Tsai T … Hatt H (Experimental dermatology 2017) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for OR51B5 Gene

Sources for OR51B5 Gene

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