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Aliases for OR51B4 Gene

Aliases for OR51B4 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 4 2 3 5
  • Odorant Receptor HOR5beta1 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 4 2
  • Olfactory Receptor 51B4 3
  • HOR5Beta1 3

External Ids for OR51B4 Gene

Previous GeneCards Identifiers for OR51B4 Gene

  • GC11M006070
  • GC11M005624
  • GC11M005281
  • GC11M005286
  • GC11M005279
  • GC11M005325

Summaries for OR51B4 Gene

Entrez Gene Summary for OR51B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B4 Gene

OR51B4 (Olfactory Receptor Family 51 Subfamily B Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.

UniProtKB/Swiss-Prot for OR51B4 Gene

  • Odorant receptor.

Gene Wiki entry for OR51B4 Gene

Additional gene information for OR51B4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51B4 Gene

Genomics for OR51B4 Gene

GeneHancer (GH) Regulatory Elements for OR51B4 Gene

Promoters and enhancers for OR51B4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005279 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +20.9 20921 2.6 HDGF PKNOX1 SMAD1 ARNT ZNF766 E2F8 FOS DEK JUNB REST GC11M005280 HBG2 HBD HBB ENSG00000221031 OR51B4 HBG1 GC11M005283 GC11P005064 HBE1
GH11J005274 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 10.2 +26.4 26405 2.2 HDGF ATF1 ARNT TCF12 POLR2B GATA2 ATF7 NCOA1 ZNF592 MBD2 HBD HBG2 HBB HBG1 HBBP1 ENSG00000221031 OR51V1 OR51B4 GC11M005280 ENSG00000284931
GH11J005269 Promoter 1 EPDnew 10 +32.0 31981 0.1 HDAC1 HNRNPUL1 MEIS2 GTF2F1 PKNOX1 SMAD1 NFATC3 TAF9B POLR2B MTA3 HBE1 FAM160A2 HBBP1 HBD HBB ENSG00000221031 HBG1 OR51V1 OR51B4 TRIM34
GH11J005361 Enhancer 0.9 Ensembl ENCODE 10.5 -63.6 -63587 7.4 JUN CHAMP1 IRF9 CC2D1A ZNF316 POLR2A NFE2 MAFK CAVIN1 ZNF740 OR51B5 ENSG00000224091 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 LOC100288935
GH11J005272 Enhancer 0.7 dbSUPER 10 +29.1 29084 1.6 HDGF BACH1 CEBPG ZNF316 NFE2 ATF7 MAFK NFE2L2 MAFG CEBPB HBG1 HBD HBBP1 HBB ENSG00000221031 OR51V1 OR51B4 HBG2 GC11M005280 ENSG00000284931
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51B4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR51B4 gene promoter:
  • RORalpha1
  • AREB6
  • AML1a
  • Ik-2
  • FOXL1
  • TBP
  • HNF-3beta
  • GATA-1

Genomic Locations for OR51B4 Gene

Genomic Locations for OR51B4 Gene
933 bases
Minus strand
983 bases
Minus strand

Genomic View for OR51B4 Gene

Genes around OR51B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B4 Gene

Proteins for OR51B4 Gene

  • Protein details for OR51B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 51B4
    Protein Accession:
    Secondary Accessions:
    • A7MAV5
    • Q6NTD7

    Protein attributes for OR51B4 Gene

    310 amino acids
    Molecular mass:
    34912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B4 Gene

Post-translational modifications for OR51B4 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51B4 Gene

Domains & Families for OR51B4 Gene

Gene Families for OR51B4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51B4 Gene

Suggested Antigen Peptide Sequences for OR51B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B4: view

Function for OR51B4 Gene

Molecular function for OR51B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51B4 Gene

Gene Ontology (GO) - Molecular Function for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51B4: view
genes like me logo Genes that share phenotypes with OR51B4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51B4 Gene

Localization for OR51B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51B4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51B4 Gene

Pathways & Interactions for OR51B4 Gene

genes like me logo Genes that share pathways with OR51B4: view

Pathways by source for OR51B4 Gene

Interacting Proteins for OR51B4 Gene

Gene Ontology (GO) - Biological Process for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B4: view

No data available for SIGNOR curated interactions for OR51B4 Gene

Drugs & Compounds for OR51B4 Gene

No Compound Related Data Available

Transcripts for OR51B4 Gene

mRNA/cDNA for OR51B4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51B4 Gene

Olfactory receptor, family 51, subfamily B, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B4 Gene

No ASD Table

Relevant External Links for OR51B4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR51B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51B4 Gene

Protein differential expression in normal tissues from HIPED for OR51B4 Gene

This gene is overexpressed in Liver (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51B4 Gene

Protein tissue co-expression partners for OR51B4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51B4 Gene:


SOURCE GeneReport for Unigene cluster for OR51B4 Gene:

genes like me logo Genes that share expression patterns with OR51B4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51B4 Gene

Orthologs for OR51B4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC745918 33
  • 98.82 (n)
OR51B4 34
  • 97 (a)
(Canis familiaris)
Mammalia LOC100684060 33
  • 82.26 (n)
OR51B4 34
  • 79 (a)
(Rattus norvegicus)
Mammalia Olr130 33
  • 79.1 (n)
(Mus musculus)
Mammalia Or51b4 51 Olfr66 16 34 33
  • 78.92 (n)
Olfr64 34
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
-- 34
  • 70 (a)
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves -- 34
  • 41 (a)
Species where no ortholog for OR51B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51B4 Gene

Gene Tree for OR51B4 (if available)
Gene Tree for OR51B4 (if available)
Evolutionary constrained regions (ECRs) for OR51B4: view image

Paralogs for OR51B4 Gene

Paralogs for OR51B4 Gene

(379) SIMAP similar genes for OR51B4 Gene using alignment to 2 proteins:

  • O51B4_HUMAN
  • A4FU14_HUMAN Pseudogenes for OR51B4 Gene

genes like me logo Genes that share paralogs with OR51B4: view

Variants for OR51B4 Gene

Sequence variations from dbSNP and Humsavar for OR51B4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1006751164 -- 5,300,708(-) T/C downstream_transcript_variant
rs1006860024 -- 5,302,172(-) T/C upstream_transcript_variant
rs1006874857 -- 5,302,871(-) G/A upstream_transcript_variant
rs1006890898 -- 5,302,353(-) G/A upstream_transcript_variant
rs1007878587 -- 5,300,872(-) G/A downstream_transcript_variant

Variation tolerance for OR51B4 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.02; 84.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR51B4 Gene

Disorders for OR51B4 Gene

Additional Disease Information for OR51B4

No disorders were found for OR51B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51B4 Gene

Publications for OR51B4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  3. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M … von Doorninck JH (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 58
  4. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H … D'Andrea AD (Molecular cell 2014) 3 58
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for OR51B4 Gene

Sources for OR51B4 Gene

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