Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51B4 Gene

Aliases for OR51B4 Gene

  • Olfactory Receptor Family 51 Subfamily B Member 4 2 3 5
  • Odorant Receptor HOR5'Beta1 3 4
  • Olfactory Receptor 51B4 3 4
  • Olfactory Receptor, Family 51, Subfamily B, Member 4 2
  • EC 2.4.2.22 50
  • HOR5'Beta1 3
  • EC 1.3.3.1 50
  • OR51B4 5

External Ids for OR51B4 Gene

Previous GeneCards Identifiers for OR51B4 Gene

  • GC11M006070
  • GC11M005624
  • GC11M005281
  • GC11M005286
  • GC11M005279
  • GC11M005325
  • GC11M005302
  • GC11M005307
  • GC11M005319
  • GC11M005362
  • GC11M005386

Summaries for OR51B4 Gene

Entrez Gene Summary for OR51B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51B4 Gene

OR51B4 (Olfactory Receptor Family 51 Subfamily B Member 4) is a Protein Coding gene. Diseases associated with OR51B4 include Spherocytosis, Type 2 and Retinal Arteries, Tortuosity Of. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.

UniProtKB/Swiss-Prot Summary for OR51B4 Gene

Gene Wiki entry for OR51B4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51B4 Gene

Genomics for OR51B4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51B4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005303 Enhancer 0.4 Ensembl 250.7 -2.0 -1955 1 NFIC TAL1 TCF12 CBFA2T3 OR51B4 HBG2 HSALNG0082366 OR51B3P OR51B2 HBE1 OR51B5 ENSG00000239920
GH11J005361 Enhancer 0.9 Ensembl ENCODE 10.5 -63.6 -63587 7.4 ZNF592 NFIC EP300 ZNF316 NFE2 RELA IRF9 EHMT2 MAFK MAFG OR51B5 ENSG00000224091 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 ENSG00000236248
GH11J005269 Promoter 0.8 EPDnew 10 +32.0 31981 0.1 NCOR1 ZNF592 SMAD5 TBP TAF9B POLR2A SUPT5H ETV1 HDAC2 ATF4 HBE1 HBBP1 HBD HBB FHIP1B ENSG00000221031 HBG1 OR51V1 OR51B4 lnc-OR51B4-3
GH11J005270 Enhancer 0.3 Ensembl 10 +31.2 31245 0.6 NR2F1 HBG1 HBBP1 HBD HBB ENSG00000221031 OR51V1 OR51B4 HBG2 lnc-OR51B4-3 ENSG00000284931
GH11J004429 Enhancer 0.2 ENCODE 6.1 +871.5 871481 2.4 OR52P2P OR51B4 OR52K3P OR51R1P OR52K2 TRIM21 lnc-OR52K2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51B4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51B4

Top Transcription factor binding sites by QIAGEN in the OR51B4 gene promoter:
  • AML1a
  • AREB6
  • FOXL1
  • GATA-1
  • HNF-3beta
  • Ik-2
  • RORalpha1
  • TBP

Genomic Locations for OR51B4 Gene

Latest Assembly
chr11:5,301,014-5,301,946
(GRCh38/hg38)
Size:
933 bases
Orientation:
Minus strand

Previous Assembly
chr11:5,322,244-5,323,176
(GRCh37/hg19 by Entrez Gene)
Size:
933 bases
Orientation:
Minus strand

chr11:5,322,244-5,323,226
(GRCh37/hg19 by Ensembl)
Size:
983 bases
Orientation:
Minus strand

Genomic View for OR51B4 Gene

Genes around OR51B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51B4 Gene

Proteins for OR51B4 Gene

  • Protein details for OR51B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P0-O51B4_HUMAN
    Recommended name:
    Olfactory receptor 51B4
    Protein Accession:
    Q9Y5P0
    Secondary Accessions:
    • A7MAV5
    • Q6NTD7

    Protein attributes for OR51B4 Gene

    Size:
    310 amino acids
    Molecular mass:
    34912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51B4 Gene

Selected DME Specific Peptides for OR51B4 Gene

Q9Y5P0:
  • SLAIVES
  • TVMGLSF

Post-translational modifications for OR51B4 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Domains & Families for OR51B4 Gene

Gene Families for OR51B4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51B4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR51B4 Gene

GenScript: Design optimal peptide antigens:
  • OR51B4 protein (A4FU14_HUMAN)
  • Odorant receptor HOR5'beta1 (O51B4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5P0

UniProtKB/Swiss-Prot:

O51B4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51B4: view

Function for OR51B4 Gene

Molecular function for OR51B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Enzyme Numbers (IUBMB) for OR51B4 Gene

Phenotypes From GWAS Catalog for OR51B4 Gene

Gene Ontology (GO) - Molecular Function for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51B4: view
genes like me logo Genes that share phenotypes with OR51B4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51B4

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51B4 Gene

Localization for OR51B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51B4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51B4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51B4 Gene

Pathways & Interactions for OR51B4 Gene

genes like me logo Genes that share pathways with OR51B4: view

Pathways by source for OR51B4 Gene

Interacting Proteins for OR51B4 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000369573 Q9Y5P0-O51B4_HUMAN for OR51B4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR51B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51B4: view

No data available for SIGNOR curated interactions for OR51B4 Gene

Drugs & Compounds for OR51B4 Gene

No Compound Related Data Available

Transcripts for OR51B4 Gene

mRNA/cDNA for OR51B4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51B4

Alternative Splicing Database (ASD) splice patterns (SP) for OR51B4 Gene

No ASD Table

Relevant External Links for OR51B4 Gene

GeneLoc Exon Structure for
OR51B4

Expression for OR51B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51B4 Gene

Protein differential expression in normal tissues from HIPED for OR51B4 Gene

This gene is overexpressed in Liver (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51B4 Gene



Protein tissue co-expression partners for OR51B4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51B4

SOURCE GeneReport for Unigene cluster for OR51B4 Gene:

Hs.679499
genes like me logo Genes that share expression patterns with OR51B4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51B4 Gene

Orthologs for OR51B4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51B4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC745918 29
  • 98.82 (n)
OR51B4 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100684060 29
  • 82.26 (n)
OR51B4 30
  • 79 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr130 29
  • 79.1 (n)
Mouse
(Mus musculus)
Mammalia Or51b4 45 Olfr66 29 16 30
  • 78.92 (n)
OneToMany
Olfr64 30
  • 73 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 41 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 41 (a)
OneToMany
Species where no ortholog for OR51B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR51B4 Gene

ENSEMBL:
Gene Tree for OR51B4 (if available)
TreeFam:
Gene Tree for OR51B4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51B4: view image
Alliance of Genome Resources:
Additional Orthologs for OR51B4

Paralogs for OR51B4 Gene

(379) SIMAP similar genes for OR51B4 Gene using alignment to 2 proteins:

  • O51B4_HUMAN
  • A4FU14_HUMAN

Pseudogenes.org Pseudogenes for OR51B4 Gene

genes like me logo Genes that share paralogs with OR51B4: view

Variants for OR51B4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51B4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10837771 -- p.Met147Thr
rs7118113 -- p.Val36Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR51B4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR51B4 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.02; 84.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51B4
Leiden Open Variation Database (LOVD)
OR51B4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR51B4 Gene

Disorders for OR51B4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR51B4 Gene - From: COP

Disorder Aliases PubMed IDs
spherocytosis, type 2
  • sph2
retinal arteries, tortuosity of
  • rator
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR51B4

genes like me logo Genes that share disorders with OR51B4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51B4 Gene

Publications for OR51B4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M … von Doorninck JH (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4
  4. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H … D'Andrea AD (Molecular cell 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR51B4 Gene

Sources for OR51B4 Gene