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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
OR51B2 (Olfactory Receptor Family 51 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51B6.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J005623 | Promoter/Enhancer | 2 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 1.9 | -301.1 | -301084 | 3.2 | SP1 REST POLR2A STAT3 RELA PKNOX1 SMAD5 RCOR1 HDAC1 CEBPB | TRIM34 lnc-OR52H1-1 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 | |
GH11J005546 | Enhancer | 0.2 | FANTOM5 | 5.2 | -221.9 | -221894 | 0.1 | OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1 | ||
GH11J005328 | Enhancer | 0.2 | FANTOM5 | 3.3 | -4.8 | -4826 | 0.4 | piR-48209-076 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 | ||
GH11J005379 | Enhancer | 0.2 | FANTOM5 | 2.1 | -55.6 | -55640 | 0 | piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 | ||
GH11J005342 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | -19.3 | -19344 | 1.9 | RELA IKZF2 DPF2 JUN FOS EP300 IKZF1 MTA2 | OR51B5 OR51B6 OR51B8P OR51B2 lnc-HBE1-1 HBE1 HBG2 ENSG00000239920 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC745965 30 |
|
||
Dog (Canis familiaris) |
Mammalia | LOC485258 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or51b17 46 Olfr64 30 17 |
|
|
|
Rat (Rattus norvegicus) |
Mammalia | Olr131 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
730590 | Benign: not provided | 5,323,848(-) | A/G | SYNONYMOUS_VARIANT | |
776565 | Benign: not provided | 5,324,294(-) | A/C | MISSENSE_VARIANT | |
rs10837814 | - | p.Leu134Phe | |||
rs11036814 | - | p.Ser312Arg | |||
rs11036815 | - | p.Pro283Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1046068 | CNV | gain | 25217958 |
nsv1048608 | CNV | gain | 25217958 |
nsv524400 | CNV | loss | 19592680 |
nsv819271 | CNV | gain | 19587683 |
No disorders were found for OR51B2 Gene.