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Aliases for OR51A7 Gene

Aliases for OR51A7 Gene

  • Olfactory Receptor Family 51 Subfamily A Member 7 2 3 5
  • Olfactory Receptor OR11-27 3 4
  • Olfactory Receptor, Family 51, Subfamily A, Member 7 2
  • Olfactory Receptor 51A7 3
  • OR11-27 3

External Ids for OR51A7 Gene

Previous GeneCards Identifiers for OR51A7 Gene

  • GC11U990525
  • GC11P004893

Summaries for OR51A7 Gene

Entrez Gene Summary for OR51A7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51A7 Gene

OR51A7 (Olfactory Receptor Family 51 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51A4.

UniProtKB/Swiss-Prot for OR51A7 Gene

  • Odorant receptor.

Gene Wiki entry for OR51A7 Gene

Additional gene information for OR51A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51A7 Gene

Genomics for OR51A7 Gene

GeneHancer (GH) Regulatory Elements for OR51A7 Gene

Promoters and enhancers for OR51A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I004492 Enhancer 0.2 FANTOM5 6.4 -411.4 -411367 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11I004892 Enhancer 0.6 ENCODE 0.4 -11.5 -11547 0 SMARCE1 ARNT NFRKB FOSL1 NFIC JUND HMBOX1 NFE2 ZNF24 FOS OR51A6P OR51G1 OR51H1 OR51A7 MMP26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR51A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR51A7 gene promoter:

Genomic Locations for OR51A7 Gene

Genomic Locations for OR51A7 Gene
chr11:4,903,783-4,909,462
(GRCh38/hg38)
Size:
5,680 bases
Orientation:
Plus strand
chr11:4,928,600-4,929,538
(GRCh37/hg19)

Genomic View for OR51A7 Gene

Genes around OR51A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51A7 Gene

Proteins for OR51A7 Gene

  • Protein details for OR51A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH64-O51A7_HUMAN
    Recommended name:
    Olfactory receptor 51A7
    Protein Accession:
    Q8NH64
    Secondary Accessions:
    • Q6IFH8

    Protein attributes for OR51A7 Gene

    Size:
    312 amino acids
    Molecular mass:
    35132 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51A7 Gene

Post-translational modifications for OR51A7 Gene

Other Protein References for OR51A7 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51A7 Gene

Domains & Families for OR51A7 Gene

Gene Families for OR51A7 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51A7 Gene

Suggested Antigen Peptide Sequences for OR51A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH64

UniProtKB/Swiss-Prot:

O51A7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51A7: view

Function for OR51A7 Gene

Molecular function for OR51A7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51A7: view
genes like me logo Genes that share phenotypes with OR51A7: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51A7 Gene

Localization for OR51A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51A7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51A7 Gene

Pathways & Interactions for OR51A7 Gene

genes like me logo Genes that share pathways with OR51A7: view

Pathways by source for OR51A7 Gene

Interacting Proteins for OR51A7 Gene

Gene Ontology (GO) - Biological Process for OR51A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51A7: view

No data available for SIGNOR curated interactions for OR51A7 Gene

Drugs & Compounds for OR51A7 Gene

No Compound Related Data Available

Transcripts for OR51A7 Gene

mRNA/cDNA for OR51A7 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51A7 Gene

No ASD Table

Relevant External Links for OR51A7 Gene

GeneLoc Exon Structure for
OR51A7
ECgene alternative splicing isoforms for
OR51A7

Expression for OR51A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51A7 Gene

mRNA differential expression in normal tissues according to GTEx for OR51A7 Gene

This gene is overexpressed in Testis (x38.9), Cervix - Ectocervix (x7.2), and Cervix - Endocervix (x6.9).

Protein differential expression in normal tissues from HIPED for OR51A7 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR51A7 Gene



Protein tissue co-expression partners for OR51A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51A7 Gene:

OR51A7

SOURCE GeneReport for Unigene cluster for OR51A7 Gene:

Hs.553560
genes like me logo Genes that share expression patterns with OR51A7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51A7 Gene

Orthologs for OR51A7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466358 33
  • 98.93 (n)
OR51A7 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR51A7 33 34
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Olr68 33
  • 86.47 (n)
mouse
(Mus musculus)
Mammalia Or51a7 51 Olfr576 33 16 34
  • 86 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 70 (a)
OneToMany
Species where no ortholog for OR51A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51A7 Gene

ENSEMBL:
Gene Tree for OR51A7 (if available)
TreeFam:
Gene Tree for OR51A7 (if available)

Paralogs for OR51A7 Gene

Paralogs for OR51A7 Gene

(345) SIMAP similar genes for OR51A7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR51A7 Gene

genes like me logo Genes that share paralogs with OR51A7: view

Variants for OR51A7 Gene

Sequence variations from dbSNP and Humsavar for OR51A7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000365781 -- 4,906,026(+) T/G upstream_transcript_variant
rs1000863775 -- 4,905,709(+) A/G upstream_transcript_variant
rs1003043663 -- 4,906,285(+) T/C upstream_transcript_variant
rs1004210921 -- 4,908,320(+) A/G downstream_transcript_variant
rs1006005638 -- 4,905,667(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR51A7 Gene

Variant ID Type Subtype PubMed ID
esv2759799 CNV loss 17122850
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv521088 CNV loss 19592680

Variation tolerance for OR51A7 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51A7 Gene

Disorders for OR51A7 Gene

Additional Disease Information for OR51A7

No disorders were found for OR51A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51A7 Gene

Publications for OR51A7 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR51A7 Gene

Sources for OR51A7 Gene

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