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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]
OR4X1 (Olfactory Receptor Family 4 Subfamily X Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4X2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | OR4X1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC483609 30 |
|
||
OR4X1 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Olr735 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Olfr1270 31 |
|
ManyToMany | |
Or4x5-ps 46 Olfr1268-ps1 |
|
|
|||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10838852 | - | p.Pro282Ser | |||
rs12798361 | - | p.Leu196Gln | |||
rs1503193 | - | p.Arg144Gly | |||
rs16905753 | - | p.Pro165Leu | |||
rs17199104 | - | p.Asp246Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1111n100 | CNV | gain | 25217958 |
dgv1112n100 | CNV | gain | 25217958 |
dgv198e214 | CNV | gain | 21293372 |
esv3891986 | CNV | gain | 25118596 |
nsv1041394 | CNV | gain | 25217958 |
nsv428253 | CNV | loss | 18775914 |
nsv467871 | CNV | gain | 19166990 |
nsv467873 | CNV | loss | 19166990 |
nsv469953 | CNV | loss | 18288195 |
nsv508628 | CNV | deletion | 20534489 |
nsv554211 | CNV | gain | 21841781 |
nsv554212 | CNV | loss | 21841781 |
No disorders were found for OR4X1 Gene.