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Aliases for OR4X1 Gene

Aliases for OR4X1 Gene

  • Olfactory Receptor Family 4 Subfamily X Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily X, Member 1 2 3
  • Olfactory Receptor OR11-104 3 4
  • Olfactory Receptor, Family 4, Subfamily X, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor 4X1 3
  • OR11-104 3

External Ids for OR4X1 Gene

Previous GeneCards Identifiers for OR4X1 Gene

  • GC11U990332
  • GC11P048250
  • GC11P048241

Summaries for OR4X1 Gene

Entrez Gene Summary for OR4X1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR4X1 Gene

OR4X1 (Olfactory Receptor Family 4 Subfamily X Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4X2.

UniProtKB/Swiss-Prot for OR4X1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4X1 Gene

Additional gene information for OR4X1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4X1 Gene

Genomics for OR4X1 Gene

GeneHancer (GH) Regulatory Elements for OR4X1 Gene

Promoters and enhancers for OR4X1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J047912 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.5 -345.0 -345029 13.2 PKNOX1 SMAD1 FOXA2 SIN3A FEZF1 ZNF766 ZNF143 FOS DEK NFYC NUP160 FNBP4 ENSG00000270060 ENSG00000200090 DDB2 ARFGAP2 KBTBD4 PTPRJ C1QTNF4 MADD
GH11J047996 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -255.0 -254968 24.6 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 JUNB REST KAT8 ENSG00000200090 FNBP4 NUP160 PTPRJ MADD ENSG00000270060 DDB2 SLC39A13 MYBPC3 CELF1
GH11J047847 Enhancer 0.4 FANTOM5 dbSUPER 4.2 -417.6 -417630 0.2 OR4X1 NUP160 YPEL5P2
GH11J048173 Enhancer 0.2 FANTOM5 2.6 -91.8 -91768 0 OR4S1 OR4C3 OR4X2 OR4B1 OR4X1 PIR60737
GH11J048266 Enhancer 0.2 FANTOM5 2.2 +2.9 2925 0 OR4B1 OR4S1 OR4X2 OR4C3 OR4X1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4X1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4X1 gene promoter:
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • Nkx3-1 v4
  • Pax-4a
  • AML1a
  • NF-kappaB1
  • NF-kappaB

Genomic Locations for OR4X1 Gene

Genomic Locations for OR4X1 Gene
918 bases
Plus strand
918 bases
Plus strand

Genomic View for OR4X1 Gene

Genes around OR4X1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4X1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4X1 Gene

Proteins for OR4X1 Gene

  • Protein details for OR4X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4X1
    Protein Accession:
    Secondary Accessions:
    • Q6IF74

    Protein attributes for OR4X1 Gene

    305 amino acids
    Molecular mass:
    34222 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4X1 Gene

Post-translational modifications for OR4X1 Gene

Other Protein References for OR4X1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4X1 Gene

Domains & Families for OR4X1 Gene

Gene Families for OR4X1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4X1 Gene

Suggested Antigen Peptide Sequences for OR4X1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4X1: view

Function for OR4X1 Gene

Molecular function for OR4X1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4X1 Gene

Gene Ontology (GO) - Molecular Function for OR4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4X1: view
genes like me logo Genes that share phenotypes with OR4X1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4X1 Gene

Localization for OR4X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4X1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4X1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4X1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4X1 Gene

Pathways & Interactions for OR4X1 Gene

genes like me logo Genes that share pathways with OR4X1: view

Pathways by source for OR4X1 Gene

Interacting Proteins for OR4X1 Gene

Gene Ontology (GO) - Biological Process for OR4X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4X1: view

No data available for SIGNOR curated interactions for OR4X1 Gene

Drugs & Compounds for OR4X1 Gene

No Compound Related Data Available

Transcripts for OR4X1 Gene

mRNA/cDNA for OR4X1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4X1 Gene

Olfactory receptor, family 4, subfamily X, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4X1 Gene

No ASD Table

Relevant External Links for OR4X1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4X1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4X1 Gene

Protein differential expression in normal tissues from HIPED for OR4X1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4X1 Gene

Protein tissue co-expression partners for OR4X1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4X1 Gene:


SOURCE GeneReport for Unigene cluster for OR4X1 Gene:

genes like me logo Genes that share expression patterns with OR4X1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4X1 Gene

Orthologs for OR4X1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4X1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR4X1 34 33
  • 84.71 (n)
(Canis familiaris)
Mammalia LOC483609 33
  • 81.56 (n)
OR4X1 34
  • 76 (a)
(Rattus norvegicus)
Mammalia Olr735 33
  • 79.93 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Mus musculus)
Mammalia Olfr1270 34
  • 59 (a)
Or4x5-ps 51 Olfr1268-ps1
  • chr2:90,110,471-90,111,387
Species where no ortholog for OR4X1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4X1 Gene

Gene Tree for OR4X1 (if available)
Gene Tree for OR4X1 (if available)

Paralogs for OR4X1 Gene

Paralogs for OR4X1 Gene

(444) SIMAP similar genes for OR4X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4X1: view

Variants for OR4X1 Gene

Sequence variations from dbSNP and Humsavar for OR4X1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001400194 -- 48,265,063(+) G/A downstream_transcript_variant
rs1001972306 -- 48,263,765(+) A/G upstream_transcript_variant
rs1002400928 -- 48,264,053(+) T/C coding_sequence_variant, missense_variant
rs1002725930 -- 48,263,404(+) C/G upstream_transcript_variant
rs1003645221 -- 48,264,766(+) A/C coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4X1 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv198e214 CNV gain 21293372
esv3891986 CNV gain 25118596
nsv1041394 CNV gain 25217958
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv467873 CNV loss 19166990
nsv469953 CNV loss 18288195
nsv508628 CNV deletion 20534489
nsv554211 CNV gain 21841781
nsv554212 CNV loss 21841781

Variation tolerance for OR4X1 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.75; 97.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4X1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4X1 Gene

Disorders for OR4X1 Gene

Additional Disease Information for OR4X1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR4X1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4X1 Gene

Publications for OR4X1 Gene

  1. A nonfunctioning single nucleotide polymorphism in olfactory receptor gene family is associated with the forced expiratory volume in the first second/the forced vital capacity values of pulmonary function test in a Japanese population. (PMID: 17964544) Takabatake N … Kubota I (Biochemical and biophysical research communications 2007) 3 44 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L … Hanemann CO (Oncogene 2016) 3 58
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58

Products for OR4X1 Gene

Sources for OR4X1 Gene

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