OR4S2 Gene (Protein Coding)

Olfactory Receptor Family 4 Subfamily S Member 2

GC11P055652
GIFtS:
29
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4S2 Gene

Aliases for OR4S2 Gene

  • Olfactory Receptor Family 4 Subfamily S Member 2 2 3 5
  • Olfactory Receptor, Family 4, Subfamily S, Member 2 Pseudogene 2 3
  • Olfactory Receptor OR11-137 3 4
  • Olfactory Receptor 4S2 3 4
  • OR4S2P 3 4
  • OST725 2 3
  • Olfactory Receptor, Family 4, Subfamily S, Member 2 2
  • OR11-137 3
  • OR4S2 5

External Ids for OR4S2 Gene

Previous HGNC Symbols for OR4S2 Gene

  • OR4S2P

Previous GeneCards Identifiers for OR4S2 Gene

  • GC11U900030
  • GC11P055163
  • GC11P055164
  • GC11P055418

Summaries for OR4S2 Gene

Entrez Gene Summary for OR4S2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4S2 Gene

OR4S2 (Olfactory Receptor Family 4 Subfamily S Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4B1.

UniProtKB/Swiss-Prot Summary for OR4S2 Gene

Gene Wiki entry for OR4S2 Gene

Additional gene information for OR4S2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4S2 Gene

Genomics for OR4S2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR4S2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J055430 Enhancer 0.2 FANTOM5 3.6 -218.0 -217996 0 OR4A10P lnc-OR4A15-1 lnc-OR4A15-2 piR-31432-087 piR-40154-027 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4S2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4S2

Top Transcription factor binding sites by QIAGEN in the OR4S2 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HOXA9
  • HOXA9B
  • ITF-2
  • Meis-1
  • Meis-1b
  • Pax-4a
  • PPAR-alpha
  • Tal-1beta

Genomic Locations for OR4S2 Gene

Latest Assembly
chr11:55,648,327-55,652,854
(GRCh38/hg38)
Size:
4,528 bases
Orientation:
Plus strand

Previous Assembly
chr11:55,415,803-55,420,330
(GRCh37/hg19 by Entrez Gene)
Size:
4,528 bases
Orientation:
Plus strand

chr11:55,418,380-55,419,315
(GRCh37/hg19 by Ensembl)
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR4S2 Gene

Genes around OR4S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4S2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR4S2 Gene

Proteins for OR4S2 Gene

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  2. Protein products for research
  3. Assay products for research

  • Protein details for OR4S2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH73-OR4S2_HUMAN
    Recommended name:
    Olfactory receptor 4S2
    Protein Accession:
    Q8NH73
    Secondary Accessions:
    • Q6IF72

    Protein attributes for OR4S2 Gene

    Size:
    311 amino acids
    Molecular mass:
    35172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4S2 Gene

Protein Expression for OR4S2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR4S2 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4S2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibodies for research

  • Boster Bio Antibodies for OR4S2

No data available for DME Specific Peptides for OR4S2 Gene

Domains & Families for OR4S2 Gene

Gene Families for OR4S2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4S2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4S2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-137 (OR4S2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH73

UniProtKB/Swiss-Prot:

OR4S2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4S2: view

Function for OR4S2 Gene

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  6. Cell Lines for research

Molecular function for OR4S2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4S2 Gene

Gene Ontology (GO) - Molecular Function for OR4S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4S2: view

Phenotypes for OR4S2 Gene

GenomeRNAi human phenotypes for OR4S2:
genes like me logo Genes that share phenotypes with OR4S2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4S2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4S2 Gene

Localization for OR4S2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4S2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4S2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4S2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4S2 Gene

Pathways & Interactions for OR4S2 Gene

genes like me logo Genes that share pathways with OR4S2: view

Pathways by source for OR4S2 Gene

1 KEGG pathway for OR4S2 Gene

Interacting Proteins for OR4S2 Gene

Selected Interacting proteins: Q8NH73-OR4S2_HUMAN for OR4S2 Gene via IID

GPS-Prot Interaction Network for OR4S2

Gene Ontology (GO) - Biological Process for OR4S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4S2: view

No data available for SIGNOR curated interactions for OR4S2 Gene

Drugs & Compounds for OR4S2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OR4S2 Gene

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mRNA/cDNA for OR4S2 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4S2

Alternative Splicing Database (ASD) splice patterns (SP) for OR4S2 Gene

No ASD Table

Relevant External Links for OR4S2 Gene

GeneLoc Exon Structure for
OR4S2

Expression for OR4S2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4S2 Gene

mRNA expression in normal human tissues for OR4S2 Gene
mRNA expression by GTEx for OR4S2 GenemRNA expression by BioGPS for OR4S2 Gene

Protein differential expression in normal tissues from HIPED for OR4S2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4S2 Gene



Protein tissue co-expression partners for OR4S2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4S2

SOURCE GeneReport for Unigene cluster for OR4S2 Gene:

Hs.553621
genes like me logo Genes that share expression patterns with OR4S2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4S2 Gene

Orthologs for OR4S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4S2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC466536 29
  • 99.04 (n)
OR4S2 30
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OR4S2 30
  • 89 (a)
 OneToOne
LOC100682721 29
  • 88.96 (n)
Oppossum
(Monodelphis domestica)
 Mammalia OR4S2 30
  • 86 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Olr649 29
  • 84.35 (n)
Mouse
(Mus musculus)
 Mammalia Or4s2b 45 Olfr1193 29 16 30
  • 84.03 (n)
 OneToOne
Or4s2 45 Olfr1191
  • chr2:88,642,748-88,643,701
Platypus
(Ornithorhynchus anatinus)
 Mammalia OR4S2 30
  • 80 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia OR4S2 30
  • 78 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LOC100859598 29
  • 67.76 (n)
Species where no ortholog for OR4S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4S2 Gene

ENSEMBL:
Gene Tree for OR4S2 (if available)
TreeFam:
Gene Tree for OR4S2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4S2: view image
Alliance of Genome Resources:
Additional Orthologs for OR4S2

Paralogs for OR4S2 Gene

Paralogs for OR4S2 Gene

(449) SIMAP similar genes for OR4S2 Gene using alignment to 1 proteins:

  • OR4S2_HUMAN
genes like me logo Genes that share paralogs with OR4S2: view

Variants for OR4S2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4S2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17146960 -- p.Ser72Thr
rs7949664 -- p.Val195Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4S2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4S2 Gene

Variant ID Type Subtype PubMed ID
dgv10e213 CNV loss 24956385
dgv10n64 CNV loss 17921354
dgv1172n100 CNV gain 25217958
dgv1173n100 CNV gain 25217958
dgv1176n100 CNV gain 25217958
dgv1178n100 CNV gain+loss 25217958
dgv1179n100 CNV loss 25217958
dgv1184n100 CNV loss 25217958
dgv1185n100 CNV gain+loss 25217958
dgv1186n100 CNV gain+loss 25217958
dgv1187n100 CNV gain 25217958
dgv1188n100 CNV gain+loss 25217958
dgv1189n100 CNV gain 25217958
dgv1190n100 CNV gain 25217958
dgv1191n100 CNV loss 25217958
dgv1192n100 CNV loss 25217958
dgv1193n100 CNV loss 25217958
dgv1194n100 CNV gain+loss 25217958
dgv1195n100 CNV loss 25217958
dgv1196n100 CNV gain 25217958
dgv1197n100 CNV gain+loss 25217958
dgv1198n100 CNV loss 25217958
dgv1199n100 CNV gain 25217958
dgv11n64 CNV gain+loss 17921354
dgv1200n100 CNV loss 25217958
dgv1201n100 CNV gain+loss 25217958
dgv1202n100 CNV gain 25217958
dgv1203n100 CNV loss 25217958
dgv12n47 CNV loss 21111241
dgv12n68 CNV loss 17160897
dgv13n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv144n27 CNV gain 19166990
dgv145n27 CNV loss 19166990
dgv146n27 CNV gain 19166990
dgv148n27 CNV loss 19166990
dgv149n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv1908n54 CNV gain 21841781
dgv1909n54 CNV loss 21841781
dgv1914n54 CNV loss 21841781
dgv1915n54 CNV gain+loss 21841781
dgv1916n54 CNV loss 21841781
dgv1920n54 CNV loss 21841781
dgv1923n54 CNV loss 21841781
dgv1927n54 CNV gain+loss 21841781
dgv1928n54 CNV loss 21841781
dgv1929n54 CNV loss 21841781
dgv1931n54 CNV loss 21841781
dgv1933n54 CNV loss 21841781
dgv1934n54 CNV loss 21841781
dgv211e199 CNV deletion 23128226
dgv217n67 CNV loss 20364138
dgv368e212 CNV loss 25503493
dgv369e212 CNV gain 25503493
dgv370e212 CNV loss 25503493
dgv371e212 CNV gain 25503493
dgv372e212 CNV gain 25503493
dgv373e212 CNV gain 25503493
dgv374e212 CNV loss 25503493
dgv375e212 CNV loss 25503493
dgv376e212 CNV gain 25503493
dgv377e212 CNV loss 25503493
dgv378e212 CNV loss 25503493
dgv379e212 CNV gain 25503493
dgv380e212 CNV gain 25503493
dgv381e212 CNV loss 25503493
dgv382e212 CNV gain 25503493
dgv383e212 CNV loss 25503493
dgv384e212 CNV loss 25503493
dgv385e212 CNV gain 25503493
dgv386e212 CNV loss 25503493
dgv48n111 CNV deletion 26073780
dgv4e49 CNV loss 18971310
dgv50e55 CNV loss 17911159
dgv5e49 CNV loss 18971310
dgv6n14 CNV loss 18776910
esv22842 CNV gain+loss 19812545
esv2421634 CNV deletion 20811451
esv2663268 CNV deletion 23128226
esv2751030 CNV gain 17911159
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv2760311 CNV gain+loss 21179565
esv29944 CNV loss 18421352
esv3380977 OTHER inversion 20981092
esv33874 CNV gain 17666407
esv3579560 CNV gain 25503493
esv3579649 CNV gain 25503493
esv3579680 CNV loss 25503493
esv3579688 CNV loss 25503493
esv3579709 CNV loss 25503493
esv3579710 CNV loss 25503493
esv3626445 CNV loss 21293372
esv3626446 CNV gain 21293372
esv3892006 CNV gain+loss 25118596
esv3892007 CNV loss 25118596
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv1039780 CNV gain 25217958
nsv1041927 CNV gain 25217958
nsv1050425 CNV loss 25217958
nsv1050439 CNV loss 25217958
nsv1052630 CNV loss 25217958
nsv1143540 CNV deletion 24896259
nsv323 CNV deletion 18451855
nsv428256 CNV loss 18775914
nsv435950 OTHER inversion 17901297
nsv437717 CNV loss 16327808
nsv442617 CNV loss 18776908
nsv443003 CNV deletion 18674749
nsv468563 CNV loss 19166990
nsv469957 CNV gain 18288195
nsv469958 CNV loss 18288195
nsv471364 CNV gain+loss 19718026
nsv508632 CNV deletion 20534489
nsv511485 CNV gain 21212237
nsv514622 CNV loss 21397061
nsv517440 CNV gain+loss 19592680
nsv524091 CNV gain 19592680
nsv554801 CNV loss 21841781
nsv554805 CNV loss 21841781
nsv554809 CNV gain 21841781
nsv554920 CNV loss 21841781
nsv554971 CNV gain 21841781
nsv554994 CNV loss 21841781
nsv555013 CNV loss 21841781
nsv555029 CNV loss 21841781
nsv71 CNV deletion 15895083
nsv818824 CNV gain 17921354
nsv818827 CNV gain 17921354
nsv821668 CNV loss 15273396
nsv825892 CNV loss 20364138
nsv825896 CNV loss 20364138
nsv8827 CNV gain+loss 18304495
nsv952449 CNV deletion 24416366
nsv972950 CNV deletion 23825009

Variation tolerance for OR4S2 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.74; 95.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4S2
Leiden Open Variation Database (LOVD)
OR4S2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4S2 Gene

Disorders for OR4S2 Gene

Additional Disease Information for OR4S2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR4S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4S2 Gene

Publications for OR4S2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  5. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y … Lancet D (Molecular biology and evolution 2003) 3

ExternalLinks

View latest publications for OR4S2 gene in Mastermind

Products for OR4S2 Gene

Sources for OR4S2 Gene