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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR4S2 (Olfactory Receptor Family 4 Subfamily S Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4B1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J055430 | Enhancer | 0.2 | FANTOM5 | 3.6 | -218.0 | -217996 | 0 | OR4A10P piR-31432-087 lnc-OR4A15-1 lnc-OR4A15-2 piR-40154-027 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466536 30 |
|
||
OR4S2 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR4S2 31 |
|
OneToOne | |
LOC100682721 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | OR4S2 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Olr649 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or4s2b 46 Olfr1193 30 17 31 |
|
OneToOne |
|
Or4s2 46 Olfr1191 |
|
|
|||
Platypus (Ornithorhynchus anatinus) |
Mammalia | OR4S2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OR4S2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC100859598 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17146960 | - | p.Ser72Thr | |||
rs7949664 | - | p.Val195Gly |
No disorders were found for OR4S2 Gene.