Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4Q2 Gene

Aliases for OR4Q2 Gene

  • Olfactory Receptor Family 4 Subfamily Q Member 2 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR14-21 3 4
  • Olfactory Receptor 4Q2 3 4
  • OR4Q2P 3 4
  • Olfactory Receptor, Family 4, Subfamily Q, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 4, Subfamily Q, Member 2 Pseudogene 2
  • OR4Q2 5

External Ids for OR4Q2 Gene

Previous HGNC Symbols for OR4Q2 Gene

  • OR4Q2P

Previous GeneCards Identifiers for OR4Q2 Gene

  • GC14P019541
  • GC14P020470
  • GC14P000596
  • GC14P020002
  • GC14P020011

Summaries for OR4Q2 Gene

Entrez Gene Summary for OR4Q2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR4Q2 Gene

OR4Q2 (Olfactory Receptor Family 4 Subfamily Q Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4Q3.

UniProtKB/Swiss-Prot Summary for OR4Q2 Gene

Additional gene information for OR4Q2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4Q2 Gene

Genomics for OR4Q2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4Q2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020011 Enhancer 0.2 Ensembl 0.4 +11.6 11588 0.2 OR4K17 OR4K14 piR-31534-162 OR4Q2 HSALNG0099763
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4Q2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4Q2

Genomic Locations for OR4Q2 Gene

Latest Assembly
chr14:19,999,913-20,004,760
(GRCh38/hg38)
Size:
4,848 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,470,221-20,471,351
(GRCh37/hg19 by Entrez Gene)
Size:
1,131 bases
Orientation:
Plus strand

chr14:20,470,322-20,471,265
(GRCh37/hg19 by Ensembl)
Size:
944 bases
Orientation:
Plus strand

Genomic View for OR4Q2 Gene

Genes around OR4Q2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4Q2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4Q2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4Q2 Gene

Proteins for OR4Q2 Gene

  • Protein details for OR4Q2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C623-OR4Q2_HUMAN
    Recommended name:
    Olfactory receptor 4Q2
    Protein Accession:
    P0C623
    Secondary Accessions:
    • A0A087X1L2

    Protein attributes for OR4Q2 Gene

    Size:
    307 amino acids
    Molecular mass:
    34733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4Q2 Gene

Post-translational modifications for OR4Q2 Gene

  • Glycosylation at Asn4

Other Protein References for OR4Q2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR4Q2 Gene

Domains & Families for OR4Q2 Gene

Gene Families for OR4Q2 Gene

Protein Domains for OR4Q2 Gene

Suggested Antigen Peptide Sequences for OR4Q2 Gene

GenScript: Design optimal peptide antigens:
  • olfactory receptor OR14-21 (OR4Q2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C623

UniProtKB/Swiss-Prot:

OR4Q2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4Q2: view

Function for OR4Q2 Gene

Molecular function for OR4Q2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4Q2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4Q2 Gene

Localization for OR4Q2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4Q2 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4Q2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR4Q2 Gene

Pathways & Interactions for OR4Q2 Gene

genes like me logo Genes that share pathways with OR4Q2: view

Pathways by source for OR4Q2 Gene

Interacting Proteins for OR4Q2 Gene

Gene Ontology (GO) - Biological Process for OR4Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4Q2: view

No data available for SIGNOR curated interactions for OR4Q2 Gene

Drugs & Compounds for OR4Q2 Gene

No Compound Related Data Available

Transcripts for OR4Q2 Gene

mRNA/cDNA for OR4Q2 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4Q2 Gene

No ASD Table

Relevant External Links for OR4Q2 Gene

GeneLoc Exon Structure for
OR4Q2

Expression for OR4Q2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4Q2 Gene

Protein differential expression in normal tissues from HIPED for OR4Q2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4Q2 Gene



Protein tissue co-expression partners for OR4Q2 Gene

genes like me logo Genes that share expression patterns with OR4Q2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4Q2 Gene

Orthologs for OR4Q2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4Q2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR4Q2 30
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR4Q2 30
  • 51 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr1507 30
  • 37 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 35 (a)
ManyToMany
Species where no ortholog for OR4Q2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4Q2 Gene

ENSEMBL:
Gene Tree for OR4Q2 (if available)
TreeFam:
Gene Tree for OR4Q2 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4Q2

Paralogs for OR4Q2 Gene

(453) SIMAP similar genes for OR4Q2 Gene using alignment to 1 proteins:

  • OR4Q2_HUMAN

Pseudogenes.org Pseudogenes for OR4Q2 Gene

genes like me logo Genes that share paralogs with OR4Q2: view

Variants for OR4Q2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4Q2 Gene

OR4Q2_HUMAN-P0C623
A single nucleotide insertion at position Cys-180 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4Q2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR4Q2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4Q2
Leiden Open Variation Database (LOVD)
OR4Q2

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR4Q2 Gene

Disorders for OR4Q2 Gene

Additional Disease Information for OR4Q2

No disorders were found for OR4Q2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4Q2 Gene

Publications for OR4Q2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4

Products for OR4Q2 Gene

Sources for OR4Q2 Gene