Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4P4 Gene

Aliases for OR4P4 Gene

  • Olfactory Receptor Family 4 Subfamily P Member 4 2 3 5
  • Olfactory Receptor 4P4 3 4
  • Olfactory Receptor 4P3 3 4
  • OR4P3P 3 4
  • Olfactory Receptor, Family 4, Subfamily P, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily P, Member 4 2
  • OR4P4 5

External Ids for OR4P4 Gene

Previous HGNC Symbols for OR4P4 Gene

  • OR4P3P

Previous GeneCards Identifiers for OR4P4 Gene

  • GC11U990533
  • GC11P055162
  • GC11P055405

Summaries for OR4P4 Gene

Entrez Gene Summary for OR4P4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4P4 Gene

OR4P4 (Olfactory Receptor Family 4 Subfamily P Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4S2.

UniProtKB/Swiss-Prot Summary for OR4P4 Gene

Gene Wiki entry for OR4P4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4P4 Gene

Genomics for OR4P4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4P4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055430 Enhancer 0.2 FANTOM5 1.7 -204.8 -204782 0 OR4A10P lnc-OR4A15-1 lnc-OR4A15-2 piR-31432-087 piR-40154-027 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4P4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4P4

Top Transcription factor binding sites by QIAGEN in the OR4P4 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • NF-kappaB1
  • NF-kappaB2
  • PPAR-alpha

Genomic Locations for OR4P4 Gene

Latest Assembly
5,197 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
939 bases
Plus strand

(GRCh37/hg19 by Ensembl)
939 bases
Plus strand

Genomic View for OR4P4 Gene

Genes around OR4P4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4P4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4P4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4P4 Gene

Proteins for OR4P4 Gene

  • Protein details for OR4P4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4P4
    Protein Accession:

    Protein attributes for OR4P4 Gene

    312 amino acids
    Molecular mass:
    35795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4P4 Gene

Post-translational modifications for OR4P4 Gene

  • Glycosylation at Asn5 and Asn6

Other Protein References for OR4P4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4P4 Gene

Domains & Families for OR4P4 Gene

Gene Families for OR4P4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4P4 Gene

  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4P4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 4P3 (OR4P4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4P4: view

Function for OR4P4 Gene

Molecular function for OR4P4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4P4 Gene

Gene Ontology (GO) - Molecular Function for OR4P4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4P4: view
genes like me logo Genes that share phenotypes with OR4P4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4P4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4P4 Gene

Localization for OR4P4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4P4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4P4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4P4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4P4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4P4 Gene

Pathways & Interactions for OR4P4 Gene

genes like me logo Genes that share pathways with OR4P4: view

Pathways by source for OR4P4 Gene

Interacting Proteins for OR4P4 Gene

Gene Ontology (GO) - Biological Process for OR4P4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4P4: view

No data available for SIGNOR curated interactions for OR4P4 Gene

Drugs & Compounds for OR4P4 Gene

No Compound Related Data Available

Transcripts for OR4P4 Gene

mRNA/cDNA for OR4P4 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4P4

Alternative Splicing Database (ASD) splice patterns (SP) for OR4P4 Gene

No ASD Table

Relevant External Links for OR4P4 Gene

GeneLoc Exon Structure for

Expression for OR4P4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4P4 Gene

Protein differential expression in normal tissues from HIPED for OR4P4 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4P4 Gene

Protein tissue co-expression partners for OR4P4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4P4

SOURCE GeneReport for Unigene cluster for OR4P4 Gene:

genes like me logo Genes that share expression patterns with OR4P4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4P4 Gene

Orthologs for OR4P4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4P4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747017 29
  • 99.14 (n)
(Canis familiaris)
Mammalia OR4P4 29 30
  • 84.91 (n)
(Rattus norvegicus)
Mammalia Olr648 29
  • 84.8 (n)
(Mus musculus)
Mammalia Or4p19 45 Olfr1180 30
  • 75 (a)
Or4a27 45 Olfr1197
  • chr2:88,728,656-88,729,618
Or4a66 45 Olfr1196
  • chr2:88,700,386-88,701,348
Or4a67 45 Olfr1200
  • chr2:88,767,306-88,768,334
Or4p18 45 Olfr1179
  • chr2:88,402,012-88,402,932
Or4p20 45 Olfr1181
  • chr2:88,423,091-88,424,023
Or4p21 45 Olfr1182
  • chr2:88,446,022-88,446,936
Or4p22 45 Olfr1184
  • chr2:88,486,734-88,487,666
Or4p23 45 Olfr1198
  • chr2:88,745,963-88,746,886
Or4p4 45 Olfr1192
  • chr2:88,652,154-88,653,080
Or4p4b-ps 45 Olfr475-ps1
  • chr2:88,623,305-88,624,230
Or4p7 45 Olfr1178
  • chr2:88,391,249-88,392,217
Or4p8 45 Olfr1208
  • chr2:88,896,672-88,897,595
(Monodelphis domestica)
Mammalia OR4P4 30
  • 68 (a)
(Bos Taurus)
Mammalia OR4P4 30
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 66 (a)
-- 30
  • 64 (a)
Species where no ortholog for OR4P4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4P4 Gene

Gene Tree for OR4P4 (if available)
Gene Tree for OR4P4 (if available)
Evolutionary constrained regions (ECRs) for OR4P4: view image
Alliance of Genome Resources:
Additional Orthologs for OR4P4

Paralogs for OR4P4 Gene

(444) SIMAP similar genes for OR4P4 Gene using alignment to 1 proteins:


Pseudogenes.org Pseudogenes for OR4P4 Gene

genes like me logo Genes that share paralogs with OR4P4: view

Variants for OR4P4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4P4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4P4 Gene

Variant ID Type Subtype PubMed ID
dgv10e213 CNV loss 24956385
dgv10n64 CNV loss 17921354
dgv1172n100 CNV gain 25217958
dgv1173n100 CNV gain 25217958
dgv1175n100 CNV loss 25217958
dgv1176n100 CNV gain 25217958
dgv1177n100 CNV gain+loss 25217958
dgv1178n100 CNV gain+loss 25217958
dgv1179n100 CNV loss 25217958
dgv1182n100 CNV loss 25217958
dgv1183n100 CNV gain+loss 25217958
dgv1184n100 CNV loss 25217958
dgv1185n100 CNV gain+loss 25217958
dgv1186n100 CNV gain+loss 25217958
dgv1187n100 CNV gain 25217958
dgv1188n100 CNV gain+loss 25217958
dgv1189n100 CNV gain 25217958
dgv1190n100 CNV gain 25217958
dgv1191n100 CNV loss 25217958
dgv1192n100 CNV loss 25217958
dgv1193n100 CNV loss 25217958
dgv1194n100 CNV gain+loss 25217958
dgv1195n100 CNV loss 25217958
dgv1196n100 CNV gain 25217958
dgv1197n100 CNV gain+loss 25217958
dgv1198n100 CNV loss 25217958
dgv1199n100 CNV gain 25217958
dgv11n64 CNV gain+loss 17921354
dgv1200n100 CNV loss 25217958
dgv1201n100 CNV gain+loss 25217958
dgv12n47 CNV loss 21111241
dgv12n68 CNV loss 17160897
dgv13n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv144n27 CNV gain 19166990
dgv145n27 CNV loss 19166990
dgv146n27 CNV gain 19166990
dgv147n27 CNV loss 19166990
dgv148n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv1907n54 CNV loss 21841781
dgv1908n54 CNV gain 21841781
dgv1909n54 CNV loss 21841781
dgv1911n54 CNV loss 21841781
dgv1912n54 CNV gain+loss 21841781
dgv1913n54 CNV gain+loss 21841781
dgv1914n54 CNV loss 21841781
dgv1915n54 CNV gain+loss 21841781
dgv1916n54 CNV loss 21841781
dgv1920n54 CNV loss 21841781
dgv1922n54 CNV loss 21841781
dgv1923n54 CNV loss 21841781
dgv1926n54 CNV loss 21841781
dgv1927n54 CNV gain+loss 21841781
dgv1928n54 CNV loss 21841781
dgv1929n54 CNV loss 21841781
dgv1930n54 CNV loss 21841781
dgv1931n54 CNV loss 21841781
dgv1932n54 CNV loss 21841781
dgv1933n54 CNV loss 21841781
dgv1934n54 CNV loss 21841781
dgv211e199 CNV deletion 23128226
dgv217n67 CNV loss 20364138
dgv368e212 CNV loss 25503493
dgv369e212 CNV gain 25503493
dgv370e212 CNV loss 25503493
dgv371e212 CNV gain 25503493
dgv372e212 CNV gain 25503493
dgv373e212 CNV gain 25503493
dgv374e212 CNV loss 25503493
dgv375e212 CNV loss 25503493
dgv376e212 CNV gain 25503493
dgv377e212 CNV loss 25503493
dgv378e212 CNV loss 25503493
dgv379e212 CNV gain 25503493
dgv380e212 CNV gain 25503493
dgv381e212 CNV loss 25503493
dgv382e212 CNV gain 25503493
dgv48n111 CNV deletion 26073780
dgv4e49 CNV loss 18971310
dgv50e55 CNV loss 17911159
dgv5e49 CNV loss 18971310
dgv6n14 CNV loss 18776910
dgv9n64 CNV gain+loss 17921354
esv22842 CNV gain+loss 19812545
esv2421634 CNV deletion 20811451
esv2663268 CNV deletion 23128226
esv2751030 CNV gain 17911159
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv2760311 CNV gain+loss 21179565
esv29944 CNV loss 18421352
esv3380977 OTHER inversion 20981092
esv33874 CNV gain 17666407
esv3579560 CNV gain 25503493
esv3579649 CNV gain 25503493
esv3579680 CNV loss 25503493
esv3579686 CNV loss 25503493
esv3579687 CNV loss 25503493
esv3579688 CNV loss 25503493
esv3626445 CNV loss 21293372
esv3626446 CNV gain 21293372
esv3892006 CNV gain+loss 25118596
esv3892007 CNV loss 25118596
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv1037763 CNV gain 25217958
nsv1039780 CNV gain 25217958
nsv1041927 CNV gain 25217958
nsv1050439 CNV loss 25217958
nsv1143540 CNV deletion 24896259
nsv323 CNV deletion 18451855
nsv428256 CNV loss 18775914
nsv435950 OTHER inversion 17901297
nsv437717 CNV loss 16327808
nsv442617 CNV loss 18776908
nsv443003 CNV deletion 18674749
nsv467886 CNV gain 19166990
nsv469957 CNV gain 18288195
nsv469958 CNV loss 18288195
nsv471363 CNV loss 19718026
nsv508632 CNV deletion 20534489
nsv511485 CNV gain 21212237
nsv514622 CNV loss 21397061
nsv517440 CNV gain+loss 19592680
nsv518225 CNV loss 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv554803 CNV gain 21841781
nsv554805 CNV loss 21841781
nsv554809 CNV gain 21841781
nsv554915 CNV gain 21841781
nsv554920 CNV loss 21841781
nsv554971 CNV gain 21841781
nsv554994 CNV loss 21841781
nsv71 CNV deletion 15895083
nsv818824 CNV gain 17921354
nsv818827 CNV gain 17921354
nsv821668 CNV loss 15273396
nsv825892 CNV loss 20364138
nsv825896 CNV loss 20364138
nsv8827 CNV gain+loss 18304495
nsv952449 CNV deletion 24416366
nsv972950 CNV deletion 23825009

Variation tolerance for OR4P4 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.28; 92.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4P4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4P4 Gene

Disorders for OR4P4 Gene

Additional Disease Information for OR4P4

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR4P4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4P4 Gene

Publications for OR4P4 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3

Products for OR4P4 Gene

Sources for OR4P4 Gene