Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4N5 Gene

Aliases for OR4N5 Gene

  • Olfactory Receptor Family 4 Subfamily N Member 5 2 3 5
  • Olfactory Receptor OR14-33 3 4
  • Olfactory Receptor 4N5 3 4
  • Olfactory Receptor, Family 4, Subfamily N, Member 5 2
  • OR4N5 5

External Ids for OR4N5 Gene

Previous GeneCards Identifiers for OR4N5 Gene

  • GC14U990435
  • GC14P018604
  • GC14P019682
  • GC14P020611
  • GC14P020143

Summaries for OR4N5 Gene

Entrez Gene Summary for OR4N5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4N5 Gene

OR4N5 (Olfactory Receptor Family 4 Subfamily N Member 5) is a Protein Coding gene. Diseases associated with OR4N5 include Branchiootorenal Syndrome 1. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4N2.

UniProtKB/Swiss-Prot Summary for OR4N5 Gene

Gene Wiki entry for OR4N5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4N5 Gene

Genomics for OR4N5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4N5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020591 Enhancer 0.4 FANTOM5 14.5 +453.1 453051 0.1 CBX2 IKZF1 RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14J020204 Enhancer 0.2 Ensembl 11 +65.9 65881 0.6 OR11H5P OR4N5 piR-50308-157 OR11G2 OR11H6
GH14J020071 Enhancer 0.2 FANTOM5 5 -67.1 -67052 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
GH14J020176 Enhancer 1.1 Ensembl ENCODE 0.3 +40.3 40315 4.9 NCOR1 IKZF1 ZNF592 NFIC NONO HES1 MNT ARNT NFATC3 TAF9B OR11G1P lnc-OR11G2-1 METTL17 OR11G2 OR4N5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4N5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4N5

Top Transcription factor binding sites by QIAGEN in the OR4N5 gene promoter:
  • CP2
  • E47
  • Hand1
  • LCR-F1
  • RORalpha2
  • Sox9
  • SRF
  • SRF (504 AA)
  • ZIC2
  • Zic3

Genomic Locations for OR4N5 Gene

Latest Assembly
chr14:20,138,820-20,145,471
(GRCh38/hg38)
Size:
6,652 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,606,979-20,613,630
(GRCh37/hg19 by Entrez Gene)
Size:
6,652 bases
Orientation:
Plus strand

chr14:20,611,895-20,612,821
(GRCh37/hg19 by Ensembl)
Size:
927 bases
Orientation:
Plus strand

Genomic View for OR4N5 Gene

Genes around OR4N5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4N5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4N5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4N5 Gene

Proteins for OR4N5 Gene

  • Protein details for OR4N5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXE1-OR4N5_HUMAN
    Recommended name:
    Olfactory receptor 4N5
    Protein Accession:
    Q8IXE1
    Secondary Accessions:
    • Q6IF11

    Protein attributes for OR4N5 Gene

    Size:
    308 amino acids
    Molecular mass:
    34696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N5 Gene

Post-translational modifications for OR4N5 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4N5 Gene

Domains & Families for OR4N5 Gene

Gene Families for OR4N5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4N5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4N5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-33 (OR4N5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXE1

UniProtKB/Swiss-Prot:

OR4N5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N5: view

Function for OR4N5 Gene

Molecular function for OR4N5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4N5 Gene

Gene Ontology (GO) - Molecular Function for OR4N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N5: view
genes like me logo Genes that share phenotypes with OR4N5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4N5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4N5 Gene

Localization for OR4N5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4N5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OR4N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4N5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4N5 Gene

Pathways & Interactions for OR4N5 Gene

genes like me logo Genes that share pathways with OR4N5: view

Pathways by source for OR4N5 Gene

Interacting Proteins for OR4N5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000332110 Q8IXE1-OR4N5_HUMAN for OR4N5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR4N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4N5: view

No data available for SIGNOR curated interactions for OR4N5 Gene

Drugs & Compounds for OR4N5 Gene

No Compound Related Data Available

Transcripts for OR4N5 Gene

mRNA/cDNA for OR4N5 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4N5

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N5 Gene

No ASD Table

Relevant External Links for OR4N5 Gene

GeneLoc Exon Structure for
OR4N5

Expression for OR4N5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4N5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4N5

SOURCE GeneReport for Unigene cluster for OR4N5 Gene:

Hs.553766
genes like me logo Genes that share expression patterns with OR4N5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4N5 Gene

Orthologs for OR4N5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100614621 29
  • 99.13 (n)
OR4N5 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR4N5 30
  • 89 (a)
OneToOne
LOC487467 29
  • 86.36 (n)
Cow
(Bos Taurus)
Mammalia OR4N5 29 30
  • 86.8 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or4n5 45 Olfr722 29 16 30
  • 82.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1624 29
  • 81.6 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 80 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 54 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 56 (a)
OneToMany
Species where no ortholog for OR4N5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4N5 Gene

ENSEMBL:
Gene Tree for OR4N5 (if available)
TreeFam:
Gene Tree for OR4N5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4N5: view image
Alliance of Genome Resources:
Additional Orthologs for OR4N5

Paralogs for OR4N5 Gene

(448) SIMAP similar genes for OR4N5 Gene using alignment to 1 proteins:

  • OR4N5_HUMAN
genes like me logo Genes that share paralogs with OR4N5: view

Variants for OR4N5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4N5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs10131326 -- p.Asn191Asp
rs10134472 -- p.Cys260Arg
rs10140908 -- p.Ser234Thr
rs10141025 -- p.Arg290His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4N5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4N5 Gene

Variant ID Type Subtype PubMed ID
dgv3532n54 CNV loss 21841781
dgv81e55 CNV gain 17911159
esv2751268 CNV gain 17911159
esv2761819 CNV loss 21179565
esv3580929 CNV loss 25503493
nsv1037890 CNV gain 25217958
nsv521393 CNV loss 19592680
nsv832738 CNV loss 17160897
nsv832739 CNV gain 17160897

Variation tolerance for OR4N5 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4N5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4N5
Leiden Open Variation Database (LOVD)
OR4N5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N5 Gene

Disorders for OR4N5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR4N5 Gene - From: COP

Disorder Aliases PubMed IDs
branchiootorenal syndrome 1
  • bor1
- elite association - COSMIC cancer census association via MalaCards
Search OR4N5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR4N5

genes like me logo Genes that share disorders with OR4N5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4N5 Gene

Publications for OR4N5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4N5 Gene

Sources for OR4N5 Gene