Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4N4 Gene

Aliases for OR4N4 Gene

  • Olfactory Receptor Family 4 Subfamily N Member 4 2 3 5
  • Olfactory Receptor OR15-1 3 4
  • Olfactory Receptor OR15-5 3 4
  • Olfactory Receptor 4N4 3 4
  • Olfactory Receptor, Family 4, Subfamily N, Member 4 2
  • OR15-1 3
  • OR15-5 3
  • OR4N4 5

External Ids for OR4N4 Gene

Previous GeneCards Identifiers for OR4N4 Gene

  • GC15U990129
  • GC15P019779
  • GC15P019883
  • GC15P019804
  • GC15P022382

Summaries for OR4N4 Gene

Entrez Gene Summary for OR4N4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4N4 Gene

OR4N4 (Olfactory Receptor Family 4 Subfamily N Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000285472.

UniProtKB/Swiss-Prot Summary for OR4N4 Gene

Gene Wiki entry for OR4N4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4N4 Gene

Genomics for OR4N4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4N4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J022243 Enhancer 0.2 FANTOM5 16.7 +149.3 149254 0.1 OR4N4 OR4M2 lnc-POTEB-4 HSALNG0104437 LOC101928039 LOC107983983 GOLGA6L22
GH15J022217 Enhancer 0.6 FANTOM5 Ensembl ENCODE 4.7 +122.1 122078 3.2 MNT OR4M2 OR4N4 piR-43104-017 HSALNG0104433 piR-48820-035 lnc-POTEB-4 LOC107983983 LOC101928039 GOLGA6L22
GH15J021282 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 3.6 -811.2 -811190 1.7 BHLHE40 IKZF1 IKZF2 CTCF OR4N4 OR4M2 piR-38141-001 lnc-POTEB3-2 POTEB3 IGHD1OR15-1B
GH15J022157 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +66.7 66668 6.6 SP1 ZNF207 EBF1 SMARCA5 ASH2L BHLHE40 ELF1 IKZF1 RB1 NR2F1 HSALNG0104428-002 HSALNG0104429-002 IGHV1OR15-1 LOC107984785 OR4N4 IGHV4OR15-8
GH15J021271 Enhancer 0.9 FANTOM5 Ensembl dbSUPER 1.4 -822.6 -822614 3 NFE2 IKZF1 JUNB IKZF2 ZBTB17 ZNF680 ETV6 OR4N4 HSALNG0104406 LOC105370714 LOC105370715 lnc-POTEB3-2 lnc-LINC02203-12 POTEB3 IGHD1OR15-1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4N4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4N4

Top Transcription factor binding sites by QIAGEN in the OR4N4 gene promoter:
  • AML1a
  • Bach2
  • c-Ets-1
  • C/EBPalpha
  • Meis-1
  • Meis-1a
  • Meis-1b
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR4N4 Gene

Latest Assembly
1,341 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,434 bases
Plus strand

(GRCh37/hg19 by Ensembl)
1,126 bases
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr15(PATCHES):1,323,146-1,324,485 (+)

Genomic View for OR4N4 Gene

Genes around OR4N4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4N4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4N4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4N4 Gene

Proteins for OR4N4 Gene

  • Protein details for OR4N4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4N4
    Protein Accession:
    Secondary Accessions:
    • Q6IEY3
    • Q6IF56

    Protein attributes for OR4N4 Gene

    316 amino acids
    Molecular mass:
    35724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N4 Gene

Post-translational modifications for OR4N4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4N4 Gene

Domains & Families for OR4N4 Gene

Gene Families for OR4N4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4N4 Gene

  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4N4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR15-5 (OR4N4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N4: view

Function for OR4N4 Gene

Molecular function for OR4N4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N4: view
genes like me logo Genes that share phenotypes with OR4N4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4N4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4N4 Gene

Localization for OR4N4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OR4N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4N4: view

No data available for Subcellular locations from COMPARTMENTS for OR4N4 Gene

Pathways & Interactions for OR4N4 Gene

genes like me logo Genes that share pathways with OR4N4: view

Pathways by source for OR4N4 Gene

Interacting Proteins for OR4N4 Gene

Gene Ontology (GO) - Biological Process for OR4N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4N4: view

No data available for SIGNOR curated interactions for OR4N4 Gene

Drugs & Compounds for OR4N4 Gene

No Compound Related Data Available

Transcripts for OR4N4 Gene

mRNA/cDNA for OR4N4 Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4N4

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N4 Gene

No ASD Table

Relevant External Links for OR4N4 Gene

GeneLoc Exon Structure for

Expression for OR4N4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4N4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for OR4N4 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for OR4N4 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4N4 Gene

Protein tissue co-expression partners for OR4N4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4N4

SOURCE GeneReport for Unigene cluster for OR4N4 Gene:

genes like me logo Genes that share expression patterns with OR4N4: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4N4 Gene

Orthologs for OR4N4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR4N4 29
  • 88.13 (n)
-- 30
  • 88 (a)
-- 30
  • 85 (a)
(Canis familiaris)
Mammalia LOC482537 29
  • 88.1 (n)
OR4N4 30
  • 88 (a)
(Mus musculus)
Mammalia Or4n4 45 Olfr732 29 16 30
  • 82.25 (n)
Or4n4b 45 Olfr733 30
  • 82 (a)
(Rattus norvegicus)
Mammalia Olr1610 29
  • 81.6 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 78 (a)
-- 30
  • 77 (a)
(Gallus gallus)
Aves -- 30
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 56 (a)
Species where no ortholog for OR4N4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4N4 Gene

Gene Tree for OR4N4 (if available)
Gene Tree for OR4N4 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4N4

Paralogs for OR4N4 Gene

(450) SIMAP similar genes for OR4N4 Gene using alignment to 1 proteins:


Pseudogenes.org Pseudogenes for OR4N4 Gene

genes like me logo Genes that share paralogs with OR4N4: view

Variants for OR4N4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4N4 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs2808136 Benign: not provided 22,094,777(+) C/Tp.Leu86Phe
NM_001005241.3(OR4N4):c.256C>T (p.Leu86Phe)
rs535034 Benign: not provided 22,094,704(+) A/Cp.Leu61Phe
NM_001005241.3(OR4N4):c.183A>C (p.Leu61Phe)
rs62006708 Benign: not provided 22,094,753(+) G/C
NM_001005241.3(OR4N4):c.232G>C (p.Ala78Pro)
rs3817271 -- p.Phe274Leu
rs475947 -- p.Thr239Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4N4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4N4 Gene

Variant ID Type Subtype PubMed ID
dgv100e55 CNV loss 17911159
dgv10n14 CNV loss 18776910
dgv1163n106 CNV duplication 24896259
dgv1164n106 CNV deletion 24896259
dgv11n14 CNV gain 18776910
dgv1370e59 CNV duplication 20981092
dgv143e215 CNV deletion 23714750
dgv1n1 OTHER inversion 15895083
dgv2175n100 CNV gain 25217958
dgv2179n100 CNV gain 25217958
dgv2181n100 CNV gain 25217958
dgv2183n100 CNV loss 25217958
dgv2190n100 CNV gain+loss 25217958
dgv2191n100 CNV gain+loss 25217958
dgv2192n100 CNV loss 25217958
dgv2193n100 CNV gain+loss 25217958
dgv2213n100 CNV loss 25217958
dgv2214n100 CNV gain 25217958
dgv2238n100 CNV gain 25217958
dgv2250n100 CNV gain+loss 25217958
dgv2280n100 CNV loss 25217958
dgv2281n100 CNV gain+loss 25217958
dgv2282n100 CNV gain 25217958
dgv2283n100 CNV gain 25217958
dgv2284n100 CNV gain 25217958
dgv2290n100 CNV gain+loss 25217958
dgv2293n100 CNV loss 25217958
dgv2301n100 CNV loss 25217958
dgv2312n100 CNV gain 25217958
dgv2325n100 CNV gain+loss 25217958
dgv2327n100 CNV gain 25217958
dgv2332n100 CNV gain 25217958
dgv2333n100 CNV loss 25217958
dgv2336n100 CNV loss 25217958
dgv2347n100 CNV loss 25217958
dgv2355n100 CNV gain 25217958
dgv2363n100 CNV loss 25217958
dgv2364n100 CNV gain 25217958
dgv2365n100 CNV gain+loss 25217958
dgv2367n100 CNV gain 25217958
dgv2368n100 CNV loss 25217958
dgv2369n100 CNV gain+loss 25217958
dgv2370n100 CNV gain 25217958
dgv2371n100 CNV gain 25217958
dgv2372n100 CNV gain 25217958
dgv2373n100 CNV gain+loss 25217958
dgv2374n100 CNV loss 25217958
dgv2378n100 CNV loss 25217958
dgv2380n100 CNV gain 25217958
dgv2381n100 CNV gain 25217958
dgv2382n100 CNV loss 25217958
dgv2384n100 CNV loss 25217958
dgv2386n100 CNV gain 25217958
dgv2387n100 CNV gain 25217958
dgv2388n100 CNV gain 25217958
dgv2389n100 CNV loss 25217958
dgv2390n100 CNV gain 25217958
dgv2391n100 CNV loss 25217958
dgv2393n100 CNV gain 25217958
dgv2394n100 CNV gain+loss 25217958
dgv2395n100 CNV gain 25217958
dgv3e224 CNV gain+loss 25118596
dgv4162n54 CNV loss 21841781
dgv4222n54 CNV gain 21841781
dgv4223n54 CNV gain+loss 21841781
dgv4224n54 CNV loss 21841781
dgv422n67 CNV gain 20364138
dgv4244n54 CNV loss 21841781
dgv4258n54 CNV loss 21841781
dgv4259n54 CNV gain 21841781
dgv4260n54 CNV gain+loss 21841781
dgv4261n54 CNV gain 21841781
dgv4262n54 CNV loss 21841781
dgv4263n54 CNV loss 21841781
dgv4264n54 CNV gain 21841781
dgv4267n54 CNV gain+loss 21841781
dgv4273n54 CNV loss 21841781
dgv4274n54 CNV loss 21841781
dgv4276n54 CNV gain 21841781
dgv4277n54 CNV gain+loss 21841781
dgv4278n54 CNV loss 21841781
dgv4281n54 CNV loss 21841781
dgv4282n54 CNV loss 21841781
dgv4283n54 CNV loss 21841781
dgv4284n54 CNV loss 21841781
dgv4285n54 CNV loss 21841781
dgv4286n54 CNV gain 21841781
dgv4287n54 CNV gain 21841781
dgv436e214 CNV gain 21293372
dgv437e214 CNV gain 21293372
dgv7n31 CNV gain 19718026
dgv92e55 CNV gain 17911159
dgv93e55 CNV gain 17911159
dgv96e55 CNV loss 17911159
dgv99e55 CNV gain 17911159
dgv9n14 CNV loss 18776910
esv1004259 OTHER inversion 20482838
esv2659516 CNV deletion 23128226
esv2751492 CNV gain 17911159
esv29701 CNV gain+loss 19812545
esv33051 CNV gain+loss 17666407
esv3584854 CNV gain 24956385
esv3584876 CNV gain 24956385
esv3584887 CNV gain 24956385
esv3635770 CNV loss 21293372
esv3635776 CNV loss 21293372
esv3892606 CNV gain+loss 25118596
esv3892607 CNV gain 25118596
esv3892609 CNV gain 25118596
esv3892612 CNV gain 25118596
nsv1037560 CNV gain+loss 25217958
nsv1049464 CNV gain 25217958
nsv1077799 CNV duplication 25765185
nsv1152123 CNV duplication 26484159
nsv428296 CNV gain+loss 18775914
nsv435657 CNV deletion 17901297
nsv442688 CNV gain 18776908
nsv469630 CNV gain+loss 16826518
nsv510653 CNV deletion 20534489
nsv511041 OTHER inversion 20534489
nsv514767 CNV gain+loss 21397061
nsv567312 CNV gain 21841781
nsv567725 CNV gain 21841781
nsv568016 CNV loss 21841781
nsv568033 CNV loss 21841781
nsv568056 CNV loss 21841781
nsv7260 OTHER inversion 18451855
nsv817667 CNV gain 17921354
nsv817668 CNV gain+loss 17921354
nsv819100 CNV gain 19587683
nsv821678 CNV loss 15273396
nsv832918 CNV gain+loss 17160897
nsv9179 CNV gain+loss 18304495
nsv952559 CNV duplication 24416366

Variation tolerance for OR4N4 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.37; 95.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4N4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N4 Gene

Disorders for OR4N4 Gene

Additional Disease Information for OR4N4

No disorders were found for OR4N4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4N4 Gene

Publications for OR4N4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR4N4 Gene

Sources for OR4N4 Gene