OR4N2 Gene (Protein Coding)

Olfactory Receptor Family 4 Subfamily N Member 2

GC14P020115
GIFtS:
33
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone... See more...

Aliases for OR4N2 Gene

Aliases for OR4N2 Gene

  • Olfactory Receptor Family 4 Subfamily N Member 2 2 3 5
  • Olfactory Receptor OR14-13 3 4
  • Olfactory Receptor OR14-8 3 4
  • Olfactory Receptor 4N2 3 4
  • Olfactory Receptor, Family 4, Subfamily N, Member 2 2
  • OR14-13 3
  • OR14-8 3
  • OR4N2 5

External Ids for OR4N2 Gene

Previous GeneCards Identifiers for OR4N2 Gene

  • GC14U990418
  • GC14P018286
  • GC14P019341
  • GC14P020295
  • GC14P020187
  • GC14P019722
  • GC14P019734
  • GC14P019753
  • GC14P019766
  • GC14P019794
  • GC14P019723
  • GC14P019837
  • GC14P019913

Summaries for OR4N2 Gene

Entrez Gene Summary for OR4N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]

GeneCards Summary for OR4N2 Gene

OR4N2 (Olfactory Receptor Family 4 Subfamily N Member 2) is a Protein Coding gene. Diseases associated with OR4N2 include Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is LOC102723532.

UniProtKB/Swiss-Prot Summary for OR4N2 Gene

Gene Wiki entry for OR4N2 Gene

Additional gene information for OR4N2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4N2 Gene

Genomics for OR4N2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR4N2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J020071 Enhancer 0.2 FANTOM5 2.7 +352.8 352753 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4N2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4N2

Top Transcription factor binding sites by QIAGEN in the OR4N2 gene promoter:
  • C/EBPbeta
  • E47
  • FOXO1
  • FOXO1a
  • HOXA5
  • ITF-2
  • LCR-F1
  • Tal-1
  • Tal-1beta
  • TBP

Genomic Locations for OR4N2 Gene

Latest Assembly
chr14:19,719,015-19,830,253
(GRCh38/hg38)
Size:
111,239 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,271,929-20,298,412
(GRCh37/hg19 by Entrez Gene)
Size:
26,484 bases
Orientation:
Plus strand

chr14:20,187,174-20,296,531
(GRCh37/hg19 by Ensembl)
Size:
109,358 bases
Orientation:
Plus strand

Genomic View for OR4N2 Gene

Genes around OR4N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4N2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR4N2 Gene

Proteins for OR4N2 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for OR4N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGD1-OR4N2_HUMAN
    Recommended name:
    Olfactory receptor 4N2
    Protein Accession:
    Q8NGD1
    Secondary Accessions:
    • Q6IEY9
    • Q6IFA2

    Protein attributes for OR4N2 Gene

    Size:
    307 amino acids
    Molecular mass:
    34721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N2 Gene

Protein Expression for OR4N2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR4N2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4N2 Gene

Domains & Families for OR4N2 Gene

Gene Families for OR4N2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OR4N2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4N2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-8 (OR4N2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGD1

UniProtKB/Swiss-Prot:

OR4N2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N2: view

Function for OR4N2 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for OR4N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N2: view
genes like me logo Genes that share phenotypes with OR4N2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4N2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4N2 Gene

Localization for OR4N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4N2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4N2 Gene

Pathways & Interactions for OR4N2 Gene

genes like me logo Genes that share pathways with OR4N2: view

Pathways by source for OR4N2 Gene

1 KEGG pathway for OR4N2 Gene

Interacting Proteins for OR4N2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000319601 Q8NGD1-OR4N2_HUMAN for OR4N2 Gene via STRING IID

GPS-Prot Interaction Network for OR4N2

Gene Ontology (GO) - Biological Process for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4N2: view

No data available for SIGNOR curated interactions for OR4N2 Gene

Drugs & Compounds for OR4N2 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for OR4N2 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for OR4N2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4N2

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N2 Gene

No ASD Table

Relevant External Links for OR4N2 Gene

GeneLoc Exon Structure for
OR4N2

Expression for OR4N2 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4N2 Gene

mRNA expression in normal human tissues for OR4N2 Gene
mRNA expression by GTEx for OR4N2 Gene

mRNA differential expression in normal tissues according to GTEx for OR4N2 Gene

This gene is overexpressed in Testis (x35.2).

Protein differential expression in normal tissues from HIPED for OR4N2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4N2 Gene



Protein tissue co-expression partners for OR4N2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4N2

SOURCE GeneReport for Unigene cluster for OR4N2 Gene:

Hs.512490
genes like me logo Genes that share expression patterns with OR4N2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4N2 Gene

Orthologs for OR4N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC465195 29
  • 99.78 (n)
Cow
(Bos Taurus)
 Mammalia OR4N2 30
  • 89 (a)
 OneToOne
LOC510931 29
  • 87.08 (n)
Dog
(Canis familiaris)
 Mammalia OR4N2 29 30
  • 88.06 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Olfr733 29 16
  • 79.85 (n)
Olfr1508 30
  • 49 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 79 (a)
 ManyToMany
-- 30
  • 78 (a)
 ManyToMany
Chicken
(Gallus gallus)
 Aves -- 30
  • 53 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 56 (a)
 OneToMany
Species where no ortholog for OR4N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4N2 Gene

ENSEMBL:
Gene Tree for OR4N2 (if available)
TreeFam:
Gene Tree for OR4N2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4N2: view image
Alliance of Genome Resources:
Additional Orthologs for OR4N2

Paralogs for OR4N2 Gene

Paralogs for OR4N2 Gene

(454) SIMAP similar genes for OR4N2 Gene using alignment to 4 proteins:

  • OR4N2_HUMAN
  • G3V3W5_HUMAN
  • G3V4W1_HUMAN
  • H3BTD8_HUMAN

Pseudogenes.org Pseudogenes for OR4N2 Gene

genes like me logo Genes that share paralogs with OR4N2: view

Variants for OR4N2 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4N2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17114261 -- p.Val135Leu
rs2318279 -- p.Pro133Ser
rs2801164 -- p.Ile76Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4N2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4N2 Gene

Variant ID Type Subtype PubMed ID
dgv1050n106 CNV duplication 24896259
dgv1197e59 CNV duplication 20981092
dgv1198e59 CNV duplication 20981092
dgv1199e59 CNV duplication 20981092
dgv14e213 CNV gain 24956385
dgv1753n100 CNV gain 25217958
dgv1757n100 CNV gain 25217958
dgv1759n100 CNV gain 25217958
dgv1762n100 CNV loss 25217958
dgv1764n100 CNV loss 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1766n100 CNV gain 25217958
dgv1767n100 CNV loss 25217958
dgv1768n100 CNV gain 25217958
dgv1769n100 CNV gain 25217958
dgv1770n100 CNV gain+loss 25217958
dgv1771n100 CNV loss 25217958
dgv1772n100 CNV gain 25217958
dgv1773n100 CNV gain+loss 25217958
dgv1774n100 CNV gain 25217958
dgv1775n100 CNV gain 25217958
dgv1776n100 CNV gain 25217958
dgv1777n100 CNV loss 25217958
dgv1778n100 CNV gain 25217958
dgv1779n100 CNV loss 25217958
dgv1781n100 CNV loss 25217958
dgv1782n100 CNV gain 25217958
dgv1783n100 CNV loss 25217958
dgv1784n100 CNV gain 25217958
dgv1785n100 CNV loss 25217958
dgv1786n100 CNV gain 25217958
dgv1787n100 CNV loss 25217958
dgv1788n100 CNV loss 25217958
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3494n54 CNV loss 21841781
dgv3513n54 CNV loss 21841781
dgv3518n54 CNV gain 21841781
dgv3519n54 CNV gain 21841781
dgv3520n54 CNV gain 21841781
dgv3523n54 CNV gain 21841781
dgv3524n54 CNV gain+loss 21841781
dgv3527n54 CNV loss 21841781
dgv3528n54 CNV loss 21841781
dgv361n67 CNV gain 20364138
dgv45e180 CNV loss 20482838
dgv6n31 CNV gain 19718026
dgv79e55 CNV loss 17911159
dgv80e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
dgv82e55 CNV gain 17911159
dgv86n111 CNV duplication 26073780
dgv87n111 CNV duplication 26073780
esv1002355 CNV loss 20482838
esv23873 CNV gain+loss 19812545
esv2421752 OTHER complex 20811451
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv33527 CNV gain+loss 17666407
esv34243 CNV loss 17911159
esv3584662 CNV loss 24956385
esv3584743 CNV gain 24956385
esv3892451 CNV gain 25118596
esv3892457 CNV gain+loss 25118596
esv3892461 CNV gain 25118596
esv3892464 CNV gain 25118596
esv3892466 CNV gain 25118596
nsv1041071 CNV loss 25217958
nsv1044914 CNV loss 25217958
nsv1048393 CNV gain+loss 25217958
nsv1052062 CNV gain 25217958
nsv1077784 CNV duplication 25765185
nsv1150747 CNV duplication 26484159
nsv1160152 CNV duplication 26073780
nsv428292 CNV gain+loss 18775914
nsv433273 CNV loss 18776910
nsv433422 CNV gain 18776910
nsv442679 CNV gain 18776908
nsv511546 CNV gain 21212237
nsv514728 CNV gain 21397061
nsv563742 CNV gain 21841781
nsv563752 CNV loss 21841781
nsv563769 CNV loss 21841781
nsv563788 CNV loss 21841781
nsv563796 CNV loss 21841781
nsv563798 CNV loss 21841781
nsv563801 CNV gain 21841781
nsv819711 CNV loss 19587683
nsv821676 CNV gain 15273396
nsv826860 CNV gain 20364138
nsv832735 CNV gain 17160897
nsv9117 CNV gain+loss 18304495
nsv952808 CNV duplication 24416366
nsv974308 CNV duplication 23825009
nsv976312 CNV duplication 23825009
nsv983799 CNV duplication 23825009

Variation tolerance for OR4N2 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4N2
Leiden Open Variation Database (LOVD)
OR4N2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N2 Gene

Disorders for OR4N2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR4N2 Gene - From: COP

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
- elite association - COSMIC cancer census association via MalaCards
Search OR4N2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR4N2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR4N2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4N2 Gene

Publications for OR4N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3

ExternalLinks

View latest publications for OR4N2 gene in Mastermind

Products for OR4N2 Gene

Sources for OR4N2 Gene