Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone... See more...

Aliases for OR4N2 Gene

Aliases for OR4N2 Gene

  • Olfactory Receptor Family 4 Subfamily N Member 2 2 3 5
  • Olfactory Receptor OR14-13 3 4
  • Olfactory Receptor OR14-8 3 4
  • Olfactory Receptor 4N2 3 4
  • Olfactory Receptor, Family 4, Subfamily N, Member 2 2
  • OR14-13 3
  • OR14-8 3

External Ids for OR4N2 Gene

Previous GeneCards Identifiers for OR4N2 Gene

  • GC14U990418
  • GC14P018286
  • GC14P019341
  • GC14P020295
  • GC14P020187
  • GC14P019722
  • GC14P019734
  • GC14P019753
  • GC14P019723

Summaries for OR4N2 Gene

Entrez Gene Summary for OR4N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2014]

GeneCards Summary for OR4N2 Gene

OR4N2 (Olfactory Receptor Family 4 Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is LOC102723532.

UniProtKB/Swiss-Prot Summary for OR4N2 Gene

Gene Wiki entry for OR4N2 Gene

Additional gene information for OR4N2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4N2 Gene

Genomics for OR4N2 Gene

GeneHancer (GH) Regulatory Elements for OR4N2 Gene

Promoters and enhancers for OR4N2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020453 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 14.6 +736.4 736428 4.1 FOXK2 SIN3A ZBTB40 SP1 SREBF1 ZBTB6 LCORL MLX RBPJ POLR2A APEX1 OSGEP METTL17 SUPT16H ENSG00000258515 TEP1 ZNF219 RNASE9 RNASE12 OR11G2
GH14J020531 Enhancer 1 Ensembl ENCODE 14.6 +812.1 812109 0.6 CTCF ZBTB6 ETV6 RAD21 MLLT1 ZSCAN21 SMARCA4 PRDM1 MTA1 GMEB1 SUPT16H PARP2 ENSG00000258768 METTL3 METTL17 RNASE9 CHD8 RNASE12 OR11G2 OR4K6P
GH14J020071 Enhancer 0.2 FANTOM5 2.7 +352.8 352753 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4N2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4N2 gene promoter:
  • C/EBPbeta
  • E47
  • FOXO1
  • FOXO1a
  • HOXA5
  • ITF-2
  • LCR-F1
  • Tal-1
  • Tal-1beta
  • TBP

Genomic Locations for OR4N2 Gene

Genomic Locations for OR4N2 Gene
111,239 bases
Plus strand
109,358 bases
Plus strand

Genomic View for OR4N2 Gene

Genes around OR4N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4N2 Gene

Proteins for OR4N2 Gene

  • Protein details for OR4N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4N2
    Protein Accession:
    Secondary Accessions:
    • Q6IEY9
    • Q6IFA2

    Protein attributes for OR4N2 Gene

    307 amino acids
    Molecular mass:
    34721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4N2 Gene

Post-translational modifications for OR4N2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4N2 Gene

Domains & Families for OR4N2 Gene

Gene Families for OR4N2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OR4N2 Gene

Suggested Antigen Peptide Sequences for OR4N2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-8 (OR4N2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4N2: view

Function for OR4N2 Gene

Molecular function for OR4N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4N2: view

Phenotypes for OR4N2 Gene

genes like me logo Genes that share phenotypes with OR4N2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4N2 Gene

Localization for OR4N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4N2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4N2 Gene

Pathways & Interactions for OR4N2 Gene

genes like me logo Genes that share pathways with OR4N2: view

Pathways by source for OR4N2 Gene

Interacting Proteins for OR4N2 Gene

Gene Ontology (GO) - Biological Process for OR4N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4N2: view

No data available for SIGNOR curated interactions for OR4N2 Gene

Drugs & Compounds for OR4N2 Gene

No Compound Related Data Available

Transcripts for OR4N2 Gene

mRNA/cDNA for OR4N2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4N2 Gene

No ASD Table

Relevant External Links for OR4N2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4N2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4N2 Gene

mRNA differential expression in normal tissues according to GTEx for OR4N2 Gene

This gene is overexpressed in Testis (x35.2).

Protein differential expression in normal tissues from HIPED for OR4N2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4N2 Gene

Protein tissue co-expression partners for OR4N2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4N2 Gene:


SOURCE GeneReport for Unigene cluster for OR4N2 Gene:

genes like me logo Genes that share expression patterns with OR4N2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4N2 Gene

Orthologs for OR4N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4N2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC465195 32
  • 99.78 (n)
(Bos Taurus)
Mammalia OR4N2 33
  • 89 (a)
LOC510931 32
  • 87.08 (n)
(Canis familiaris)
Mammalia OR4N2 33 32
  • 88.06 (n)
(Mus musculus)
Mammalia Olfr733 17 32
  • 79.85 (n)
Olfr1508 33
  • 49 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 79 (a)
-- 33
  • 78 (a)
(Gallus gallus)
Aves -- 33
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 56 (a)
Species where no ortholog for OR4N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4N2 Gene

Gene Tree for OR4N2 (if available)
Gene Tree for OR4N2 (if available)
Evolutionary constrained regions (ECRs) for OR4N2: view image

Paralogs for OR4N2 Gene

(454) SIMAP similar genes for OR4N2 Gene using alignment to 4 proteins:

  • G3V3W5_HUMAN
  • G3V4W1_HUMAN

Pseudogenes.org Pseudogenes for OR4N2 Gene

genes like me logo Genes that share paralogs with OR4N2: view

Variants for OR4N2 Gene

Sequence variations from dbSNP and Humsavar for OR4N2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000034880 -- 19,803,564(+) C/T upstream_transcript_variant
rs1000086725 -- 19,803,120(+) GG/G upstream_transcript_variant
rs1000477785 -- 19,813,628(+) T/C intron_variant
rs1000511080 -- 19,823,426(+) C/T intron_variant
rs1001082421 -- 19,811,200(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4N2 Gene

Variant ID Type Subtype PubMed ID
dgv1050n106 CNV duplication 24896259
dgv1197e59 CNV duplication 20981092
dgv1198e59 CNV duplication 20981092
dgv1199e59 CNV duplication 20981092
dgv14e213 CNV gain 24956385
dgv1753n100 CNV gain 25217958
dgv1757n100 CNV gain 25217958
dgv1759n100 CNV gain 25217958
dgv1762n100 CNV loss 25217958
dgv1764n100 CNV loss 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1766n100 CNV gain 25217958
dgv1767n100 CNV loss 25217958
dgv1768n100 CNV gain 25217958
dgv1769n100 CNV gain 25217958
dgv1770n100 CNV gain+loss 25217958
dgv1771n100 CNV loss 25217958
dgv1772n100 CNV gain 25217958
dgv1773n100 CNV gain+loss 25217958
dgv1774n100 CNV gain 25217958
dgv1775n100 CNV gain 25217958
dgv1776n100 CNV gain 25217958
dgv1777n100 CNV loss 25217958
dgv1778n100 CNV gain 25217958
dgv1779n100 CNV loss 25217958
dgv1781n100 CNV loss 25217958
dgv1782n100 CNV gain 25217958
dgv1783n100 CNV loss 25217958
dgv1784n100 CNV gain 25217958
dgv1785n100 CNV loss 25217958
dgv1786n100 CNV gain 25217958
dgv1787n100 CNV loss 25217958
dgv1788n100 CNV loss 25217958
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3494n54 CNV loss 21841781
dgv3513n54 CNV loss 21841781
dgv3518n54 CNV gain 21841781
dgv3519n54 CNV gain 21841781
dgv3520n54 CNV gain 21841781
dgv3523n54 CNV gain 21841781
dgv3524n54 CNV gain+loss 21841781
dgv3527n54 CNV loss 21841781
dgv3528n54 CNV loss 21841781
dgv361n67 CNV gain 20364138
dgv45e180 CNV loss 20482838
dgv6n31 CNV gain 19718026
dgv79e55 CNV loss 17911159
dgv80e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
dgv82e55 CNV gain 17911159
dgv86n111 CNV duplication 26073780
dgv87n111 CNV duplication 26073780
esv1002355 CNV loss 20482838
esv23873 CNV gain+loss 19812545
esv2421752 OTHER complex 20811451
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv33527 CNV gain+loss 17666407
esv34243 CNV loss 17911159
esv3584662 CNV loss 24956385
esv3584743 CNV gain 24956385
esv3892451 CNV gain 25118596
esv3892457 CNV gain+loss 25118596
esv3892461 CNV gain 25118596
esv3892464 CNV gain 25118596
esv3892466 CNV gain 25118596
nsv1041071 CNV loss 25217958
nsv1044914 CNV loss 25217958
nsv1048393 CNV gain+loss 25217958
nsv1052062 CNV gain 25217958
nsv1077784 CNV duplication 25765185
nsv1150747 CNV duplication 26484159
nsv1160152 CNV duplication 26073780
nsv428292 CNV gain+loss 18775914
nsv433273 CNV loss 18776910
nsv433422 CNV gain 18776910
nsv442679 CNV gain 18776908
nsv511546 CNV gain 21212237
nsv514728 CNV gain 21397061
nsv563742 CNV gain 21841781
nsv563752 CNV loss 21841781
nsv563769 CNV loss 21841781
nsv563788 CNV loss 21841781
nsv563796 CNV loss 21841781
nsv563798 CNV loss 21841781
nsv563801 CNV gain 21841781
nsv819711 CNV loss 19587683
nsv821676 CNV gain 15273396
nsv826860 CNV gain 20364138
nsv832735 CNV gain 17160897
nsv9117 CNV gain+loss 18304495
nsv952808 CNV duplication 24416366
nsv974308 CNV duplication 23825009
nsv976312 CNV duplication 23825009
nsv983799 CNV duplication 23825009

Variation tolerance for OR4N2 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4N2 Gene

Disorders for OR4N2 Gene

Additional Disease Information for OR4N2

No disorders were found for OR4N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4N2 Gene

Publications for OR4N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 56

Products for OR4N2 Gene

Sources for OR4N2 Gene