Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4M2 Gene

Aliases for OR4M2 Gene

  • Olfactory Receptor Family 4 Subfamily M Member 2 2 3 5
  • Olfactory Receptor OR15-3 3 4
  • Olfactory Receptor 4M2 3 4
  • Olfactory Receptor, Family 4, Subfamily M, Member 2 2
  • OR15-3 3
  • OR4M2 5

External Ids for OR4M2 Gene

Previous GeneCards Identifiers for OR4M2 Gene

  • GC15U990131
  • GC15P019867
  • GC15P019869
  • GC15P022368
  • GC15P022080

Summaries for OR4M2 Gene

Entrez Gene Summary for OR4M2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4M2 Gene

OR4M2 (Olfactory Receptor Family 4 Subfamily M Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000275249.

UniProtKB/Swiss-Prot Summary for OR4M2 Gene

Gene Wiki entry for OR4M2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4M2 Gene

Genomics for OR4M2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4M2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J022217 Enhancer 0.6 FANTOM5 Ensembl ENCODE 5.4 +146.4 146359 3.2 MNT OR4M2 OR4N4 piR-43104-017 HSALNG0104433 piR-48820-035 lnc-POTEB-4 LOC107983983 LOC101928039 GOLGA6L22
GH15J022243 Enhancer 0.2 FANTOM5 15.4 +173.5 173535 0.1 OR4N4 OR4M2 lnc-POTEB-4 HSALNG0104437 LOC101928039 LOC107983983 GOLGA6L22
GH15J021282 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 2.5 -786.9 -786909 1.7 BHLHE40 IKZF1 IKZF2 CTCF OR4N4 OR4M2 piR-38141-001 lnc-POTEB3-2 POTEB3 IGHD1OR15-1B
GH15J022052 Enhancer 0.2 Ensembl 0.4 -13.8 -13840 0.4 OR4H6P lnc-OR4M2-9 OR4M2 OR4Q1P ENSG00000285472 ENSG00000284500 LOC101927079
GH15J022080 Enhancer 0.2 Ensembl 0.4 +11.4 11360 0.8 piR-49459-003 piR-47211-196 OR4M2 OR4N4 ENSG00000285472 LOC101927079
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4M2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4M2

Top Transcription factor binding sites by QIAGEN in the OR4M2 gene promoter:
  • AML1a
  • ATF-2
  • Bach2
  • c-Ets-1
  • C/EBPalpha
  • CUTL1
  • Pbx1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR4M2 Gene

Latest Assembly
chr15:22,070,241-22,083,221
(GRCh38/hg38)
Size:
12,981 bases
Orientation:
Plus strand

Previous Assembly
chr15:22,368,478-22,369,561
(GRCh37/hg19 by Entrez Gene)
Size:
1,084 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr15(PATCHES):1,309,120-1,310,203 (+)

Genomic View for OR4M2 Gene

Genes around OR4M2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4M2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4M2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4M2 Gene

Proteins for OR4M2 Gene

  • Protein details for OR4M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB6-OR4M2_HUMAN
    Recommended name:
    Olfactory receptor 4M2
    Protein Accession:
    Q8NGB6
    Secondary Accessions:
    • B9EH16
    • Q6IEY2

    Protein attributes for OR4M2 Gene

    Size:
    313 amino acids
    Molecular mass:
    35416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4M2 Gene

Post-translational modifications for OR4M2 Gene

  • Glycosylation at Asn5

Other Protein References for OR4M2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4M2 Gene

Domains & Families for OR4M2 Gene

Gene Families for OR4M2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4M2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4M2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR15-3 (OR4M2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGB6

UniProtKB/Swiss-Prot:

OR4M2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4M2: view

Function for OR4M2 Gene

Molecular function for OR4M2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4M2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4M2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4M2 Gene

Localization for OR4M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4M2 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4M2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR4M2 Gene

Pathways & Interactions for OR4M2 Gene

genes like me logo Genes that share pathways with OR4M2: view

Pathways by source for OR4M2 Gene

Interacting Proteins for OR4M2 Gene

Gene Ontology (GO) - Biological Process for OR4M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4M2: view

No data available for SIGNOR curated interactions for OR4M2 Gene

Drugs & Compounds for OR4M2 Gene

No Compound Related Data Available

Transcripts for OR4M2 Gene

mRNA/cDNA for OR4M2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4M2

Alternative Splicing Database (ASD) splice patterns (SP) for OR4M2 Gene

No ASD Table

Relevant External Links for OR4M2 Gene

GeneLoc Exon Structure for
OR4M2

Expression for OR4M2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4M2 Gene

mRNA differential expression in normal tissues according to GTEx for OR4M2 Gene

This gene is overexpressed in Testis (x49.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4M2

SOURCE GeneReport for Unigene cluster for OR4M2 Gene:

Hs.729625
genes like me logo Genes that share expression patterns with OR4M2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4M2 Gene

Orthologs for OR4M2 Gene

Evolution for OR4M2 Gene

ENSEMBL:
Gene Tree for OR4M2 (if available)
TreeFam:
Gene Tree for OR4M2 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4M2

No data available for Orthologs for OR4M2 Gene

Paralogs for OR4M2 Gene

(433) SIMAP similar genes for OR4M2 Gene using alignment to 1 proteins:

  • OR4M2_HUMAN
genes like me logo Genes that share paralogs with OR4M2: view

Variants for OR4M2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4M2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs11857531 -- p.Asp121Asn
rs12593418 -- p.Met239Val
rs1835183 -- p.Gly96Glu
rs4087943 -- p.Arg284His
rs491208 -- p.Phe225Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4M2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4M2 Gene

Variant ID Type Subtype PubMed ID
dgv100e55 CNV loss 17911159
dgv10n14 CNV loss 18776910
dgv1163n106 CNV duplication 24896259
dgv11n14 CNV gain 18776910
dgv1370e59 CNV duplication 20981092
dgv1n1 OTHER inversion 15895083
dgv2175n100 CNV gain 25217958
dgv2179n100 CNV gain 25217958
dgv2181n100 CNV gain 25217958
dgv2183n100 CNV loss 25217958
dgv2190n100 CNV gain+loss 25217958
dgv2191n100 CNV gain+loss 25217958
dgv2192n100 CNV loss 25217958
dgv2193n100 CNV gain+loss 25217958
dgv2213n100 CNV loss 25217958
dgv2214n100 CNV gain 25217958
dgv2238n100 CNV gain 25217958
dgv2250n100 CNV gain+loss 25217958
dgv2280n100 CNV loss 25217958
dgv2281n100 CNV gain+loss 25217958
dgv2282n100 CNV gain 25217958
dgv2283n100 CNV gain 25217958
dgv2284n100 CNV gain 25217958
dgv2290n100 CNV gain+loss 25217958
dgv2293n100 CNV loss 25217958
dgv2301n100 CNV loss 25217958
dgv2312n100 CNV gain 25217958
dgv2325n100 CNV gain+loss 25217958
dgv2327n100 CNV gain 25217958
dgv2331n100 CNV gain+loss 25217958
dgv2332n100 CNV gain 25217958
dgv2333n100 CNV loss 25217958
dgv2336n100 CNV loss 25217958
dgv2347n100 CNV loss 25217958
dgv2355n100 CNV gain 25217958
dgv2357n100 CNV gain+loss 25217958
dgv2363n100 CNV loss 25217958
dgv2364n100 CNV gain 25217958
dgv2365n100 CNV gain+loss 25217958
dgv2367n100 CNV gain 25217958
dgv2368n100 CNV loss 25217958
dgv2369n100 CNV gain+loss 25217958
dgv2370n100 CNV gain 25217958
dgv2371n100 CNV gain 25217958
dgv2372n100 CNV gain 25217958
dgv2373n100 CNV gain+loss 25217958
dgv2374n100 CNV loss 25217958
dgv2378n100 CNV loss 25217958
dgv2380n100 CNV gain 25217958
dgv2381n100 CNV gain 25217958
dgv2382n100 CNV loss 25217958
dgv2384n100 CNV loss 25217958
dgv2386n100 CNV gain 25217958
dgv2387n100 CNV gain 25217958
dgv2388n100 CNV gain 25217958
dgv2389n100 CNV loss 25217958
dgv2390n100 CNV gain 25217958
dgv2391n100 CNV loss 25217958
dgv2393n100 CNV gain 25217958
dgv3e224 CNV gain+loss 25118596
dgv4162n54 CNV loss 21841781
dgv4222n54 CNV gain 21841781
dgv4223n54 CNV gain+loss 21841781
dgv4224n54 CNV loss 21841781
dgv422n67 CNV gain 20364138
dgv4244n54 CNV loss 21841781
dgv4257n54 CNV loss 21841781
dgv4258n54 CNV loss 21841781
dgv4259n54 CNV gain 21841781
dgv4260n54 CNV gain+loss 21841781
dgv4261n54 CNV gain 21841781
dgv4262n54 CNV loss 21841781
dgv4263n54 CNV loss 21841781
dgv4264n54 CNV gain 21841781
dgv4267n54 CNV gain+loss 21841781
dgv4268n54 CNV loss 21841781
dgv4273n54 CNV loss 21841781
dgv4274n54 CNV loss 21841781
dgv4276n54 CNV gain 21841781
dgv4277n54 CNV gain+loss 21841781
dgv4278n54 CNV loss 21841781
dgv4279n54 CNV loss 21841781
dgv435e214 CNV gain 21293372
dgv7n31 CNV gain 19718026
dgv92e55 CNV gain 17911159
dgv93e55 CNV gain 17911159
dgv96e55 CNV loss 17911159
dgv99e55 CNV gain 17911159
dgv9n14 CNV loss 18776910
esv1004259 OTHER inversion 20482838
esv2751492 CNV gain 17911159
esv29701 CNV gain+loss 19812545
esv33051 CNV gain+loss 17666407
esv3584679 CNV loss 24956385
esv3584854 CNV gain 24956385
esv3584876 CNV gain 24956385
esv3584887 CNV gain 24956385
esv3635763 CNV loss 21293372
esv3892606 CNV gain+loss 25118596
esv3892607 CNV gain 25118596
esv3892609 CNV gain 25118596
esv3892612 CNV gain 25118596
nsv1037560 CNV gain+loss 25217958
nsv1049464 CNV gain 25217958
nsv1077799 CNV duplication 25765185
nsv1139619 CNV duplication 24896259
nsv1152123 CNV duplication 26484159
nsv1458 CNV deletion 18451855
nsv428296 CNV gain+loss 18775914
nsv442688 CNV gain 18776908
nsv469630 CNV gain+loss 16826518
nsv510653 CNV deletion 20534489
nsv511041 OTHER inversion 20534489
nsv514767 CNV gain+loss 21397061
nsv567312 CNV gain 21841781
nsv567725 CNV gain 21841781
nsv568013 CNV loss 21841781
nsv7260 OTHER inversion 18451855
nsv817667 CNV gain 17921354
nsv817668 CNV gain+loss 17921354
nsv819100 CNV gain 19587683
nsv819770 CNV gain 19587683
nsv821678 CNV loss 15273396
nsv832918 CNV gain+loss 17160897
nsv9179 CNV gain+loss 18304495
nsv952559 CNV duplication 24416366

Variation tolerance for OR4M2 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4M2 Gene

Human Gene Mutation Database (HGMD)
OR4M2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4M2
Leiden Open Variation Database (LOVD)
OR4M2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4M2 Gene

Disorders for OR4M2 Gene

Additional Disease Information for OR4M2

No disorders were found for OR4M2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4M2 Gene

Publications for OR4M2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR4M2 Gene

Sources for OR4M2 Gene