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Aliases for OR4M1 Gene

Aliases for OR4M1 Gene

  • Olfactory Receptor Family 4 Subfamily M Member 1 2 3 5
  • Olfactory Receptor OR14-7 3 4
  • Olfactory Receptor, Family 4, Subfamily M, Member 1 2
  • Olfactory Receptor 4M1 3
  • OR14-7 3

External Ids for OR4M1 Gene

Previous GeneCards Identifiers for OR4M1 Gene

  • GC14U990421
  • GC14P018234
  • GC14P019318
  • GC14P020248

Summaries for OR4M1 Gene

Entrez Gene Summary for OR4M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4M1 Gene

OR4M1 (Olfactory Receptor Family 4 Subfamily M Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000275249.

UniProtKB/Swiss-Prot for OR4M1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4M1 Gene

Additional gene information for OR4M1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4M1 Gene

Genomics for OR4M1 Gene

GeneHancer (GH) Regulatory Elements for OR4M1 Gene

Promoters and enhancers for OR4M1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020453 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.6 +682.0 682039 3.9 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 SP3 NFYC OSGEP APEX1 METTL17 SUPT16H ENSG00000258515 TEP1 TTC5 ZNF219 RNASE9 RNASE12
GH14J020531 Enhancer 0.8 ENCODE 14.6 +757.7 757663 0.2 HDAC1 FOXA2 ZNF2 RAD21 GATA2 ZNF366 ZNF143 ETV6 ZNF654 ZNF114 LINC00641 RNASE9 RNASE12 OR11G2 CKAP2P1 OR4K6P OR4H12P OR11K2P OR4M1 OR4N2
GH14J020071 Enhancer 0.3 FANTOM5 4.9 +298.3 298264 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR4M1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4M1 gene promoter:
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • Bach2
  • C/EBPalpha
  • AML1a
  • ATF-2
  • FOXF2
  • AP-1
  • Elk-1

Genomic Locations for OR4M1 Gene

Genomic Locations for OR4M1 Gene
10,193 bases
Plus strand
1,116 bases
Plus strand

Genomic View for OR4M1 Gene

Genes around OR4M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4M1 Gene

Proteins for OR4M1 Gene

  • Protein details for OR4M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4M1
    Protein Accession:
    Secondary Accessions:
    • B9EH18
    • Q6IFA3

    Protein attributes for OR4M1 Gene

    313 amino acids
    Molecular mass:
    35488 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4M1 Gene

Post-translational modifications for OR4M1 Gene

Other Protein References for OR4M1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4M1 Gene

Domains & Families for OR4M1 Gene

Gene Families for OR4M1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4M1 Gene

Suggested Antigen Peptide Sequences for OR4M1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4M1: view

Function for OR4M1 Gene

Molecular function for OR4M1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4M1: view
genes like me logo Genes that share phenotypes with OR4M1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4M1 Gene

Localization for OR4M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4M1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4M1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4M1 Gene

Pathways & Interactions for OR4M1 Gene

genes like me logo Genes that share pathways with OR4M1: view

Pathways by source for OR4M1 Gene

Gene Ontology (GO) - Biological Process for OR4M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4M1: view

No data available for SIGNOR curated interactions for OR4M1 Gene

Drugs & Compounds for OR4M1 Gene

No Compound Related Data Available

Transcripts for OR4M1 Gene

mRNA/cDNA for OR4M1 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4M1 Gene

Olfactory receptor, family 4, subfamily M, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4M1 Gene

No ASD Table

Relevant External Links for OR4M1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4M1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4M1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR4M1 Gene

This gene is overexpressed in Testis (x47.8).

NURSA nuclear receptor signaling pathways regulating expression of OR4M1 Gene:


SOURCE GeneReport for Unigene cluster for OR4M1 Gene:

genes like me logo Genes that share expression patterns with OR4M1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4M1 Gene

Orthologs for OR4M1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4M1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
(Bos Taurus)
Mammalia -- 34
  • 93 (a)
OR4M1 33
  • 90.73 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Olr1612 33
  • 86.69 (n)
(Mus musculus)
Mammalia Or4m1 51 Olfr734 16 34 33
  • 85.94 (n)
(Gallus gallus)
Aves LOC768941 33
  • 61.5 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
Species where no ortholog for OR4M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4M1 Gene

Gene Tree for OR4M1 (if available)
Gene Tree for OR4M1 (if available)
Evolutionary constrained regions (ECRs) for OR4M1: view image

Paralogs for OR4M1 Gene

(438) SIMAP similar genes for OR4M1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4M1: view

Variants for OR4M1 Gene

Sequence variations from dbSNP and Humsavar for OR4M1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000323154 -- 19,777,698(+) T/C upstream_transcript_variant
rs1002615780 -- 19,782,532(+) C/T genic_downstream_transcript_variant, intron_variant
rs1002913093 -- 19,782,850(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1004702968 -- 19,780,407(+) G/A coding_sequence_variant, missense_variant
rs1005859559 -- 19,782,511(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4M1 Gene

Variant ID Type Subtype PubMed ID
nsv1077784 CNV duplication 25765185
nsv1150747 CNV duplication 26484159
nsv1160152 CNV duplication 26073780
nsv428292 CNV gain+loss 18775914
nsv433273 CNV loss 18776910
nsv433422 CNV gain 18776910
nsv442679 CNV gain 18776908
nsv471369 CNV gain 19718026
nsv511546 CNV gain 21212237
nsv514728 CNV gain 21397061
nsv563739 CNV loss 21841781
nsv563742 CNV gain 21841781
nsv563751 CNV loss 21841781
nsv563752 CNV loss 21841781
nsv563769 CNV loss 21841781
nsv563788 CNV loss 21841781
nsv563789 CNV loss 21841781
nsv563793 CNV gain 21841781
nsv819711 CNV loss 19587683
nsv821676 CNV gain 15273396
nsv826860 CNV gain 20364138
nsv832735 CNV gain 17160897
nsv9117 CNV gain+loss 18304495
nsv952808 CNV duplication 24416366
nsv1048393 CNV gain+loss 25217958
nsv1047431 CNV loss 25217958
nsv1044659 CNV gain 25217958
nsv1042164 CNV gain+loss 25217958
nsv1038826 CNV gain 25217958
esv3892466 CNV gain 25118596
esv3892464 CNV gain 25118596
esv3892461 CNV gain 25118596
esv3892451 CNV gain 25118596
esv3584743 CNV gain 24956385
esv34243 CNV loss 17911159
esv3386871 CNV duplication 20981092
esv33527 CNV gain+loss 17666407
esv2759971 CNV gain+loss 17122850
esv2751268 CNV gain 17911159
esv2421752 OTHER complex 20811451
esv23873 CNV gain+loss 19812545
esv1002355 CNV loss 20482838
dgv87n111 CNV duplication 26073780
dgv86n111 CNV duplication 26073780
dgv82e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
dgv80e55 CNV gain 17911159
dgv79e55 CNV loss 17911159
dgv6n31 CNV gain 19718026
dgv45e180 CNV loss 20482838
dgv361n67 CNV gain 20364138
dgv3526n54 CNV loss 21841781
dgv3524n54 CNV gain+loss 21841781
dgv3523n54 CNV gain 21841781
dgv3520n54 CNV gain 21841781
dgv3519n54 CNV gain 21841781
dgv3518n54 CNV gain 21841781
dgv3513n54 CNV loss 21841781
dgv3494n54 CNV loss 21841781
dgv3489n54 CNV gain 21841781
dgv33e203 CNV gain+loss 21179565
dgv24n68 CNV gain 17160897
dgv1782n100 CNV gain 25217958
dgv1781n100 CNV loss 25217958
dgv1780n100 CNV loss 25217958
dgv1779n100 CNV loss 25217958
dgv1778n100 CNV gain 25217958
dgv1777n100 CNV loss 25217958
dgv1776n100 CNV gain 25217958
dgv1775n100 CNV gain 25217958
dgv1774n100 CNV gain 25217958
dgv1773n100 CNV gain+loss 25217958
dgv1772n100 CNV gain 25217958
dgv1771n100 CNV loss 25217958
dgv1770n100 CNV gain+loss 25217958
dgv1769n100 CNV gain 25217958
dgv1768n100 CNV gain 25217958
dgv1767n100 CNV loss 25217958
dgv1766n100 CNV gain 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1764n100 CNV loss 25217958
dgv1762n100 CNV loss 25217958
dgv1761n100 CNV gain+loss 25217958
dgv1759n100 CNV gain 25217958
dgv1757n100 CNV gain 25217958
dgv1753n100 CNV gain 25217958
dgv14e213 CNV gain 24956385
dgv1197e59 CNV duplication 20981092
dgv1050n106 CNV duplication 24896259

Variation tolerance for OR4M1 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4M1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4M1 Gene

Disorders for OR4M1 Gene

Additional Disease Information for OR4M1

No disorders were found for OR4M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4M1 Gene

Publications for OR4M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4M1 Gene

Sources for OR4M1 Gene

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