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Aliases for OR4L1 Gene

Aliases for OR4L1 Gene

  • Olfactory Receptor Family 4 Subfamily L Member 1 2 3 5
  • Olfactory Receptor OR14-28 3 4
  • Olfactory Receptor 4L2 3 4
  • OR4L2P 3 4
  • Olfactory Receptor, Family 4, Subfamily L, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily L, Member 1 2
  • Olfactory Receptor 4L1 3
  • OR14-28 3

External Ids for OR4L1 Gene

Previous HGNC Symbols for OR4L1 Gene

  • OR4L2P

Previous GeneCards Identifiers for OR4L1 Gene

  • GC14U990437
  • GC14P018519
  • GC14P019598
  • GC14P020530

Summaries for OR4L1 Gene

Entrez Gene Summary for OR4L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4L1 Gene

OR4L1 (Olfactory Receptor Family 4 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K13.

UniProtKB/Swiss-Prot for OR4L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4L1 Gene

Additional gene information for OR4L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4L1 Gene

Genomics for OR4L1 Gene

GeneHancer (GH) Regulatory Elements for OR4L1 Gene

Promoters and enhancers for OR4L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020071 Enhancer 0.3 FANTOM5 9.4 +11.7 11723 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
GH14J020488 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +430.4 430376 3.7 HDGF PKNOX1 BATF RARA ATF7 ETV6 IKZF2 BCLAF1 RUNX3 CREM PNP PIP4P1 RNA5SP382 TEP1 OR4L1 ENSG00000258908 RNASE10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4L1 gene promoter:
  • POU2F1a
  • POU2F1
  • ER-alpha
  • AML1a
  • TBP
  • STAT5A
  • FOXJ2 (long isoform)
  • FOXJ2
  • GR-alpha
  • GR

Genomic Locations for OR4L1 Gene

Genomic Locations for OR4L1 Gene
939 bases
Plus strand
939 bases
Plus strand

Genomic View for OR4L1 Gene

Genes around OR4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4L1 Gene

Proteins for OR4L1 Gene

  • Protein details for OR4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4L1
    Protein Accession:
    Secondary Accessions:
    • Q6IEZ5

    Protein attributes for OR4L1 Gene

    312 amino acids
    Molecular mass:
    35264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4L1 Gene

Post-translational modifications for OR4L1 Gene

  • Glycosylation at isoforms=268 and Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4L1 Gene

Domains & Families for OR4L1 Gene

Gene Families for OR4L1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4L1 Gene

Suggested Antigen Peptide Sequences for OR4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4L1: view

Function for OR4L1 Gene

Molecular function for OR4L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4L1 Gene

Gene Ontology (GO) - Molecular Function for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4L1: view
genes like me logo Genes that share phenotypes with OR4L1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4L1 Gene

Localization for OR4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4L1 Gene

Pathways & Interactions for OR4L1 Gene

genes like me logo Genes that share pathways with OR4L1: view

Pathways by source for OR4L1 Gene

Interacting Proteins for OR4L1 Gene

Gene Ontology (GO) - Biological Process for OR4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4L1: view

No data available for SIGNOR curated interactions for OR4L1 Gene

Drugs & Compounds for OR4L1 Gene

No Compound Related Data Available

Transcripts for OR4L1 Gene

mRNA/cDNA for OR4L1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4L1 Gene

Olfactory receptor, family 4, subfamily L, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4L1 Gene

No ASD Table

Relevant External Links for OR4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4L1 Gene

Protein differential expression in normal tissues from HIPED for OR4L1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4L1 Gene

Protein tissue co-expression partners for OR4L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4L1 Gene:


SOURCE GeneReport for Unigene cluster for OR4L1 Gene:

genes like me logo Genes that share expression patterns with OR4L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4L1 Gene

Orthologs for OR4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473314 33
  • 99.04 (n)
(Canis familiaris)
Mammalia LOC100682714 33
  • 85.58 (n)
OR4L1 34
  • 80 (a)
(Bos Taurus)
Mammalia LOC787134 33
  • 83.98 (n)
OR4L1 34
  • 81 (a)
(Mus musculus)
Mammalia Or4l1 51 Olfr723 34 33
  • 82.52 (n)
Or4l15 51 Olfr724 16 34
  • 79 (a)
(Rattus norvegicus)
Mammalia Olr1625 33
  • 82.3 (n)
(Monodelphis domestica)
Mammalia OR4L1 34
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
Species where no ortholog for OR4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4L1 Gene

Gene Tree for OR4L1 (if available)
Gene Tree for OR4L1 (if available)
Evolutionary constrained regions (ECRs) for OR4L1: view image

Paralogs for OR4L1 Gene

Paralogs for OR4L1 Gene

(445) SIMAP similar genes for OR4L1 Gene using alignment to 1 proteins:

  • OR4L1_HUMAN Pseudogenes for OR4L1 Gene

genes like me logo Genes that share paralogs with OR4L1: view

Variants for OR4L1 Gene

Sequence variations from dbSNP and Humsavar for OR4L1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000070403 -- 20,059,705(+) G/A upstream_transcript_variant
rs1002896939 -- 20,058,045(+) C/G upstream_transcript_variant
rs1003922081 -- 20,059,375(+) C/A/T upstream_transcript_variant
rs1004357569 -- 20,059,163(+) T/A upstream_transcript_variant
rs1005170840 -- 20,061,191(+) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4L1 Gene

Variant ID Type Subtype PubMed ID
dgv122n21 CNV gain 19592680
dgv1796n100 CNV gain 25217958
dgv3532n54 CNV loss 21841781
dgv81e55 CNV gain 17911159
esv22236 CNV loss 19812545
esv2421843 CNV duplication 20811451
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv2760354 CNV gain 21179565
esv3302756 CNV tandem duplication 20981092
esv3580929 CNV loss 25503493
esv3633674 CNV gain 21293372
nsv1043905 CNV gain 25217958
nsv1202 CNV deletion 18451855
nsv428292 CNV gain+loss 18775914
nsv442326 CNV gain 18776908
nsv514729 CNV gain 21397061
nsv818997 CNV gain 17921354
nsv818998 CNV gain 17921354
nsv826866 CNV loss 20364138
nsv832738 CNV loss 17160897
nsv9118 CNV gain 18304495
nsv952809 CNV duplication 24416366

Variation tolerance for OR4L1 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.62; 99.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4L1 Gene

Disorders for OR4L1 Gene

Additional Disease Information for OR4L1

No disorders were found for OR4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4L1 Gene

Publications for OR4L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4L1 Gene

Sources for OR4L1 Gene

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