Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4K5 Gene

Aliases for OR4K5 Gene

  • Olfactory Receptor Family 4 Subfamily K Member 5 2 3 5
  • Olfactory Receptor OR14-16 3 4
  • Olfactory Receptor 4K5 3 4
  • Olfactory Receptor, Family 4, Subfamily K, Member 5 2
  • OR14-16 3
  • OR4K5 5

External Ids for OR4K5 Gene

Previous GeneCards Identifiers for OR4K5 Gene

  • GC14U990416
  • GC14P019459
  • GC14P020388

Summaries for OR4K5 Gene

Entrez Gene Summary for OR4K5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K5 Gene

OR4K5 (Olfactory Receptor Family 4 Subfamily K Member 5) is a Protein Coding gene. Diseases associated with OR4K5 include Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K15.

UniProtKB/Swiss-Prot Summary for OR4K5 Gene

Gene Wiki entry for OR4K5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4K5 Gene

Genomics for OR4K5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4K5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J019974 Enhancer 0.2 Ensembl 11.1 +54.2 54219 0.4 OR4K15 OR4K5 OR4K2 piR-48209-173
GH14J019975 Enhancer 0.2 Ensembl 11.1 +52.8 52819 0.4 OR4K5 OR4K15 piR-48209-173
GH14J020071 Enhancer 0.2 FANTOM5 3 +151.2 151186 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4K5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4K5

Top Transcription factor binding sites by QIAGEN in the OR4K5 gene promoter:
  • AML1a
  • c-Myb
  • C/EBPalpha
  • Cart-1
  • Cdc5
  • CHOP-10
  • E2F
  • E2F-1
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4K5 Gene

Latest Assembly
chr14:19,920,582-19,921,659
(GRCh38/hg38)
Size:
1,078 bases
Orientation:
Plus strand

Previous Assembly
chr14:20,388,766-20,389,737
(GRCh37/hg19 by Entrez Gene)
Size:
972 bases
Orientation:
Plus strand

chr14:20,388,741-20,389,818
(GRCh37/hg19 by Ensembl)
Size:
1,078 bases
Orientation:
Plus strand

Genomic View for OR4K5 Gene

Genes around OR4K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K5 Gene

Proteins for OR4K5 Gene

  • Protein details for OR4K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGD3-OR4K5_HUMAN
    Recommended name:
    Olfactory receptor 4K5
    Protein Accession:
    Q8NGD3
    Secondary Accessions:
    • Q6IFA7

    Protein attributes for OR4K5 Gene

    Size:
    323 amino acids
    Molecular mass:
    36258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4K5 Gene

Post-translational modifications for OR4K5 Gene

  • Glycosylation at Asn5

Other Protein References for OR4K5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4K5 Gene

Domains & Families for OR4K5 Gene

Gene Families for OR4K5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4K5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4K5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 4, subfamily K, member 5 (B9EIS6_HUMAN)
  • Olfactory receptor OR14-16 (OR4K5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGD3

UniProtKB/Swiss-Prot:

OR4K5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K5: view

Function for OR4K5 Gene

Molecular function for OR4K5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K5: view
genes like me logo Genes that share phenotypes with OR4K5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4K5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4K5 Gene

Localization for OR4K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4K5 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for OR4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4K5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4K5 Gene

Pathways & Interactions for OR4K5 Gene

genes like me logo Genes that share pathways with OR4K5: view

Pathways by source for OR4K5 Gene

Interacting Proteins for OR4K5 Gene

Gene Ontology (GO) - Biological Process for OR4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4K5: view

No data available for SIGNOR curated interactions for OR4K5 Gene

Drugs & Compounds for OR4K5 Gene

No Compound Related Data Available

Transcripts for OR4K5 Gene

mRNA/cDNA for OR4K5 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4K5

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K5 Gene

No ASD Table

Relevant External Links for OR4K5 Gene

GeneLoc Exon Structure for
OR4K5

Expression for OR4K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4K5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4K5

SOURCE GeneReport for Unigene cluster for OR4K5 Gene:

Hs.554585
genes like me logo Genes that share expression patterns with OR4K5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4K5 Gene

Orthologs for OR4K5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K5 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia LOC100856122 29
  • 87.41 (n)
-- 30
  • 87 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia OR4K5 29 30
  • 87.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1630 29
  • 82.76 (n)
Mouse
(Mus musculus)
Mammalia Or4k5 45 Olfr729 29 16 30
  • 82.46 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 60 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 44 (a)
OneToMany
Species where no ortholog for OR4K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4K5 Gene

ENSEMBL:
Gene Tree for OR4K5 (if available)
TreeFam:
Gene Tree for OR4K5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4K5: view image
Alliance of Genome Resources:
Additional Orthologs for OR4K5

Paralogs for OR4K5 Gene

(456) SIMAP similar genes for OR4K5 Gene using alignment to 2 proteins:

  • OR4K5_HUMAN
  • B9EIS6_HUMAN
genes like me logo Genes that share paralogs with OR4K5: view

Variants for OR4K5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4K5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17242341 -- p.Arg319Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4K5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4K5 Gene

Variant ID Type Subtype PubMed ID
dgv1050n106 CNV duplication 24896259
dgv1206e59 CNV duplication 20981092
dgv14e213 CNV gain 24956385
dgv1753n100 CNV gain 25217958
dgv1757n100 CNV gain 25217958
dgv1759n100 CNV gain 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1766n100 CNV gain 25217958
dgv1767n100 CNV loss 25217958
dgv1768n100 CNV gain 25217958
dgv1770n100 CNV gain+loss 25217958
dgv1772n100 CNV gain 25217958
dgv1775n100 CNV gain 25217958
dgv1778n100 CNV gain 25217958
dgv1782n100 CNV gain 25217958
dgv1784n100 CNV gain 25217958
dgv1785n100 CNV loss 25217958
dgv1786n100 CNV gain 25217958
dgv1787n100 CNV loss 25217958
dgv1789n100 CNV gain 25217958
dgv1790n100 CNV loss 25217958
dgv1791n100 CNV loss 25217958
dgv1792n100 CNV gain 25217958
dgv1793n100 CNV gain 25217958
dgv1794n100 CNV loss 25217958
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3520n54 CNV gain 21841781
dgv3527n54 CNV loss 21841781
dgv3528n54 CNV loss 21841781
dgv3529n54 CNV loss 21841781
dgv361n67 CNV gain 20364138
dgv379e214 CNV gain 21293372
dgv45e180 CNV loss 20482838
dgv79e55 CNV loss 17911159
dgv80e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
dgv82e55 CNV gain 17911159
dgv86n111 CNV duplication 26073780
dgv87n111 CNV duplication 26073780
esv1002355 CNV loss 20482838
esv23873 CNV gain+loss 19812545
esv2421752 OTHER complex 20811451
esv2603885 CNV gain 19546169
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv33527 CNV gain+loss 17666407
esv34243 CNV loss 17911159
esv3436264 CNV duplication 20981092
esv3584662 CNV loss 24956385
esv3584743 CNV gain 24956385
esv3892451 CNV gain 25118596
esv3892457 CNV gain+loss 25118596
esv3892461 CNV gain 25118596
esv3892464 CNV gain 25118596
nsv1036714 CNV loss 25217958
nsv1039973 CNV gain+loss 25217958
nsv1049852 CNV loss 25217958
nsv1077784 CNV duplication 25765185
nsv1150747 CNV duplication 26484159
nsv1160152 CNV duplication 26073780
nsv428292 CNV gain+loss 18775914
nsv442679 CNV gain 18776908
nsv469855 CNV loss 16826518
nsv471372 CNV gain 19718026
nsv511546 CNV gain 21212237
nsv514728 CNV gain 21397061
nsv517699 CNV gain+loss 19592680
nsv520814 CNV loss 19592680
nsv563742 CNV gain 21841781
nsv563769 CNV loss 21841781
nsv563801 CNV gain 21841781
nsv819711 CNV loss 19587683
nsv821676 CNV gain 15273396
nsv832735 CNV gain 17160897
nsv832737 CNV gain 17160897
nsv9117 CNV gain+loss 18304495
nsv952808 CNV duplication 24416366
nsv983801 CNV duplication 23825009

Variation tolerance for OR4K5 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.91; 79.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4K5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4K5
Leiden Open Variation Database (LOVD)
OR4K5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K5 Gene

Disorders for OR4K5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR4K5 Gene - From: COP

Disorder Aliases PubMed IDs
hereditary breast ovarian cancer syndrome
  • brca1- and brca2-associated hereditary breast and ovarian cancer
- elite association - COSMIC cancer census association via MalaCards
Search OR4K5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR4K5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR4K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4K5 Gene

Publications for OR4K5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR4K5 Gene

Sources for OR4K5 Gene