Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR4K2 Gene

Aliases for OR4K2 Gene

  • Olfactory Receptor Family 4 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR14-15 3 4
  • Olfactory Receptor, Family 4, Subfamily K, Member 2 2
  • Olfactory Receptor 4K2 3
  • OR14-15 3

External Ids for OR4K2 Gene

Previous GeneCards Identifiers for OR4K2 Gene

  • GC14U990424
  • GC14P018336
  • GC14P019415
  • GC14P020344

Summaries for OR4K2 Gene

Entrez Gene Summary for OR4K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K2 Gene

OR4K2 (Olfactory Receptor Family 4 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K14.

UniProtKB/Swiss-Prot for OR4K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4K2 Gene

Additional gene information for OR4K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K2 Gene

Genomics for OR4K2 Gene

GeneHancer (GH) Regulatory Elements for OR4K2 Gene

Promoters and enhancers for OR4K2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020071 Enhancer 0.3 FANTOM5 2.6 +196.6 196626 0.2 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4K2 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • NF-kappaB2
  • SEF-1 (1)
  • AML1a
  • Nkx3-1
  • HNF-3beta
  • Nkx3-1 v1
  • Nkx3-1 v2

Genomic Locations for OR4K2 Gene

Genomic Locations for OR4K2 Gene
8,791 bases
Plus strand
1,078 bases
Plus strand

Genomic View for OR4K2 Gene

Genes around OR4K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K2 Gene

Proteins for OR4K2 Gene

  • Protein details for OR4K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4K2
    Protein Accession:
    Secondary Accessions:
    • B2RNK8
    • Q6IFA5

    Protein attributes for OR4K2 Gene

    314 amino acids
    Molecular mass:
    35357 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4K2 Gene

Post-translational modifications for OR4K2 Gene

Other Protein References for OR4K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4K2 Gene

Domains & Families for OR4K2 Gene

Gene Families for OR4K2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4K2 Gene

Suggested Antigen Peptide Sequences for OR4K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K2: view

Function for OR4K2 Gene

Molecular function for OR4K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K2: view
genes like me logo Genes that share phenotypes with OR4K2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4K2 Gene

Localization for OR4K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4K2 Gene

Pathways & Interactions for OR4K2 Gene

genes like me logo Genes that share pathways with OR4K2: view

Pathways by source for OR4K2 Gene

Interacting Proteins for OR4K2 Gene

Gene Ontology (GO) - Biological Process for OR4K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4K2: view

No data available for SIGNOR curated interactions for OR4K2 Gene

Drugs & Compounds for OR4K2 Gene

No Compound Related Data Available

Transcripts for OR4K2 Gene

mRNA/cDNA for OR4K2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4K2 Gene

Olfactory receptor, family 4, subfamily K, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K2 Gene

No ASD Table

Relevant External Links for OR4K2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4K2 Gene:


SOURCE GeneReport for Unigene cluster for OR4K2 Gene:

genes like me logo Genes that share expression patterns with OR4K2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4K2 Gene

Orthologs for OR4K2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740093 33
  • 99.58 (n)
OR4K2 34
  • 99 (a)
(Canis familiaris)
Mammalia OR4K2 34
  • 89 (a)
LOC100683454 33
  • 88.57 (n)
(Monodelphis domestica)
Mammalia OR4K2 34
  • 87 (a)
(Bos Taurus)
Mammalia OR4K2 34 33
  • 85.94 (n)
(Mus musculus)
Mammalia Or4k2 51 Olfr730 16 34 33
  • 84.71 (n)
(Rattus norvegicus)
Mammalia Olr1608 33
  • 84.29 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
Species where no ortholog for OR4K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K2 Gene

Gene Tree for OR4K2 (if available)
Gene Tree for OR4K2 (if available)
Evolutionary constrained regions (ECRs) for OR4K2: view image

Paralogs for OR4K2 Gene

Paralogs for OR4K2 Gene

(451) SIMAP similar genes for OR4K2 Gene using alignment to 1 proteins:

  • OR4K2_HUMAN Pseudogenes for OR4K2 Gene

genes like me logo Genes that share paralogs with OR4K2: view

Variants for OR4K2 Gene

Sequence variations from dbSNP and Humsavar for OR4K2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001059434 -- 19,875,086(+) C/T upstream_transcript_variant
rs1001187403 -- 19,877,432(+) T/C downstream_transcript_variant
rs1002112635 -- 19,874,353(+) C/G upstream_transcript_variant
rs1003307708 -- 19,874,325(+) A/G upstream_transcript_variant
rs1004559361 -- 19,875,499(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4K2 Gene

Variant ID Type Subtype PubMed ID
dgv1050n106 CNV duplication 24896259
dgv1204e59 CNV duplication 20981092
dgv1205e59 CNV duplication 20981092
dgv14e213 CNV gain 24956385
dgv1753n100 CNV gain 25217958
dgv1757n100 CNV gain 25217958
dgv1759n100 CNV gain 25217958
dgv1762n100 CNV loss 25217958
dgv1764n100 CNV loss 25217958
dgv1765n100 CNV gain+loss 25217958
dgv1766n100 CNV gain 25217958
dgv1767n100 CNV loss 25217958
dgv1768n100 CNV gain 25217958
dgv1770n100 CNV gain+loss 25217958
dgv1772n100 CNV gain 25217958
dgv1775n100 CNV gain 25217958
dgv1777n100 CNV loss 25217958
dgv1778n100 CNV gain 25217958
dgv1782n100 CNV gain 25217958
dgv1784n100 CNV gain 25217958
dgv1785n100 CNV loss 25217958
dgv1786n100 CNV gain 25217958
dgv1787n100 CNV loss 25217958
dgv1788n100 CNV loss 25217958
dgv1789n100 CNV gain 25217958
dgv1790n100 CNV loss 25217958
dgv33e203 CNV gain+loss 21179565
dgv3489n54 CNV gain 21841781
dgv3520n54 CNV gain 21841781
dgv3527n54 CNV loss 21841781
dgv3528n54 CNV loss 21841781
dgv361n67 CNV gain 20364138
dgv379e214 CNV gain 21293372
dgv45e180 CNV loss 20482838
dgv79e55 CNV loss 17911159
dgv80e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
dgv82e55 CNV gain 17911159
dgv86n111 CNV duplication 26073780
dgv87n111 CNV duplication 26073780
esv1002355 CNV loss 20482838
esv23873 CNV gain+loss 19812545
esv2421752 OTHER complex 20811451
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv33527 CNV gain+loss 17666407
esv34243 CNV loss 17911159
esv3584662 CNV loss 24956385
esv3584743 CNV gain 24956385
esv3892451 CNV gain 25118596
esv3892457 CNV gain+loss 25118596
esv3892461 CNV gain 25118596
esv3892464 CNV gain 25118596
nsv1049852 CNV loss 25217958
nsv1077784 CNV duplication 25765185
nsv1150747 CNV duplication 26484159
nsv1160152 CNV duplication 26073780
nsv1201 CNV deletion 18451855
nsv428292 CNV gain+loss 18775914
nsv442679 CNV gain 18776908
nsv442998 CNV duplication 18674749
nsv471370 CNV gain 19718026
nsv511546 CNV gain 21212237
nsv514728 CNV gain 21397061
nsv517699 CNV gain+loss 19592680
nsv520814 CNV loss 19592680
nsv563742 CNV gain 21841781
nsv563769 CNV loss 21841781
nsv563801 CNV gain 21841781
nsv819711 CNV loss 19587683
nsv821676 CNV gain 15273396
nsv832735 CNV gain 17160897
nsv9117 CNV gain+loss 18304495
nsv952808 CNV duplication 24416366
nsv983801 CNV duplication 23825009

Variation tolerance for OR4K2 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.14; 80.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K2 Gene

Disorders for OR4K2 Gene

Additional Disease Information for OR4K2

No disorders were found for OR4K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4K2 Gene

Publications for OR4K2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4K2 Gene

Sources for OR4K2 Gene

Loading form....