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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR4K17 (Olfactory Receptor Family 4 Subfamily K Member 17) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K15.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH14J020591 | Enhancer | 0.4 | FANTOM5 | 18.4 | +481.1 | 481132 | 0.1 | CBX2 IKZF1 | RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13 | |
GH14J020071 | Enhancer | 0.2 | FANTOM5 | 16.7 | -39.0 | -38971 | 0.2 | OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1 | ||
GH14J020011 | Enhancer | 0.2 | Ensembl | 10.6 | -99.2 | -99238 | 0.2 | OR4K17 OR4K14 piR-31534-162 OR4Q2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC736751 30 |
|
||
OR4K17 31 |
|
OneToOne | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv122n21 | CNV | gain | 19592680 |
dgv3532n54 | CNV | loss | 21841781 |
dgv81e55 | CNV | gain | 17911159 |
dgv88n111 | CNV | deletion | 26073780 |
esv2751268 | CNV | gain | 17911159 |
esv2761819 | CNV | loss | 21179565 |
esv3580929 | CNV | loss | 25503493 |
nsv1037890 | CNV | gain | 25217958 |
nsv1202 | CNV | deletion | 18451855 |
nsv832738 | CNV | loss | 17160897 |
No disorders were found for OR4K17 Gene.