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Aliases for OR4K15 Gene

Aliases for OR4K15 Gene

  • Olfactory Receptor Family 4 Subfamily K Member 15 2 3 5
  • Olfactory Receptor OR14-20 3 4
  • Olfactory Receptor, Family 4, Subfamily K, Member 15 2
  • Olfactory Receptor 4K15 3
  • OR14-20 3
  • OR4K15Q 3

External Ids for OR4K15 Gene

Previous GeneCards Identifiers for OR4K15 Gene

  • GC14U990440
  • GC14P019514
  • GC14P020443

Summaries for OR4K15 Gene

Entrez Gene Summary for OR4K15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4K15 Gene

OR4K15 (Olfactory Receptor Family 4 Subfamily K Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4K5.

UniProtKB/Swiss-Prot for OR4K15 Gene

  • Odorant receptor.

Gene Wiki entry for OR4K15 Gene

Additional gene information for OR4K15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4K15 Gene

Genomics for OR4K15 Gene

GeneHancer (GH) Regulatory Elements for OR4K15 Gene

Top Transcription factor binding sites by QIAGEN in the OR4K15 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Elk-1
  • HNF-1A
  • HNF-1
  • AML1a
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2

Genomic Locations for OR4K15 Gene

Genomic Locations for OR4K15 Gene
1,216 bases
Plus strand
1,216 bases
Plus strand

Genomic View for OR4K15 Gene

Genes around OR4K15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4K15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4K15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4K15 Gene

Proteins for OR4K15 Gene

  • Protein details for OR4K15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4K15
    Protein Accession:
    Secondary Accessions:
    • B9EIL3
    • Q6IEZ4

    Protein attributes for OR4K15 Gene

    348 amino acids
    Molecular mass:
    39088 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4K15 Gene

Post-translational modifications for OR4K15 Gene

  • Glycosylation at Asn29 and isoforms=26
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4K15 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4K15 Gene

Domains & Families for OR4K15 Gene

Gene Families for OR4K15 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4K15 Gene

Suggested Antigen Peptide Sequences for OR4K15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4K15: view

Function for OR4K15 Gene

Molecular function for OR4K15 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4K15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4K15: view
genes like me logo Genes that share phenotypes with OR4K15: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4K15 Gene

Localization for OR4K15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4K15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4K15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4K15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4K15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4K15 Gene

Pathways & Interactions for OR4K15 Gene

genes like me logo Genes that share pathways with OR4K15: view

Pathways by source for OR4K15 Gene

Interacting Proteins for OR4K15 Gene

Gene Ontology (GO) - Biological Process for OR4K15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4K15: view

No data available for SIGNOR curated interactions for OR4K15 Gene

Drugs & Compounds for OR4K15 Gene

No Compound Related Data Available

Transcripts for OR4K15 Gene

mRNA/cDNA for OR4K15 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4K15 Gene

Olfactory receptor, family 4, subfamily K, member 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4K15 Gene

No ASD Table

Relevant External Links for OR4K15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4K15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4K15 Gene

Protein differential expression in normal tissues from HIPED for OR4K15 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4K15 Gene

Protein tissue co-expression partners for OR4K15 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4K15 Gene:


SOURCE GeneReport for Unigene cluster for OR4K15 Gene:

genes like me logo Genes that share expression patterns with OR4K15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4K15 Gene

Orthologs for OR4K15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4K15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473310 33
  • 99.04 (n)
OR4K15 34
  • 99 (a)
(Bos Taurus)
Mammalia OR4K15 34
  • 92 (a)
(Canis familiaris)
Mammalia LOC100683535 33
  • 89.71 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
-- 34
  • 89 (a)
-- 34
  • 87 (a)
(Mus musculus)
Mammalia Or4k15c 51 Olfr726 34
  • 88 (a)
Or4k15 51 Olfr727 16 34 33
  • 86.52 (n)
Or4k15b 51 Olfr725 34
  • 86 (a)
Or4k35 51 Olfr1277
  • chr2:111,269,457-111,270,365
Or4k37 51 Olfr1281
  • chr2:111,328,421-111,329,335
Or4k42 51 Olfr1290
  • chr2:111,489,221-111,490,156
Or4k43-ps 51 Olfr1292-ps1
  • chr2:111,508,579-111,509,511
(Rattus norvegicus)
Mammalia Olr1627 33
  • 85.49 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
Species where no ortholog for OR4K15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4K15 Gene

Gene Tree for OR4K15 (if available)
Gene Tree for OR4K15 (if available)
Evolutionary constrained regions (ECRs) for OR4K15: view image

Paralogs for OR4K15 Gene

Paralogs for OR4K15 Gene

(454) SIMAP similar genes for OR4K15 Gene using alignment to 1 proteins:

  • OR4KF_HUMAN Pseudogenes for OR4K15 Gene

genes like me logo Genes that share paralogs with OR4K15: view

Variants for OR4K15 Gene

Sequence variations from dbSNP and Humsavar for OR4K15 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000276809 -- 19,975,335(+) A/G upstream_transcript_variant
rs1000287948 -- 19,975,068(+) A/G upstream_transcript_variant
rs1005430621 -- 19,973,925(+) T/C upstream_transcript_variant
rs1007048797 -- 19,973,872(+) G/A upstream_transcript_variant
rs1009427505 -- 19,975,015(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4K15 Gene

Variant ID Type Subtype PubMed ID
dgv1759n100 CNV gain 25217958
dgv3520n54 CNV gain 21841781
dgv3530n54 CNV gain 21841781
dgv3531n54 CNV gain 21841781
dgv3532n54 CNV loss 21841781
dgv80e55 CNV gain 17911159
dgv81e55 CNV gain 17911159
esv2751268 CNV gain 17911159
esv2759971 CNV gain+loss 17122850
esv34243 CNV loss 17911159
esv3892451 CNV gain 25118596
esv3892457 CNV gain+loss 25118596
esv3892461 CNV gain 25118596
nsv428292 CNV gain+loss 18775914
nsv469855 CNV loss 16826518
nsv520814 CNV loss 19592680
nsv832737 CNV gain 17160897
nsv974309 CNV duplication 23825009

Variation tolerance for OR4K15 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.39; 99.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4K15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4K15 Gene

Disorders for OR4K15 Gene

Additional Disease Information for OR4K15

No disorders were found for OR4K15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4K15 Gene

Publications for OR4K15 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4K15 Gene

Sources for OR4K15 Gene

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