Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4F6 Gene

Aliases for OR4F6 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 6 2 3 5
  • Olfactory Receptor, Family 4, Subfamily F, Member 12 2 3
  • Olfactory Receptor OR15-15 3 4
  • Olfactory Receptor 4F12 3 4
  • Olfactory Receptor 4F6 3 4
  • OR4F12 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 6 2
  • OR15-15 3

External Ids for OR4F6 Gene

Previous HGNC Symbols for OR4F6 Gene

  • OR4F12

Previous GeneCards Identifiers for OR4F6 Gene

  • GC15U990132
  • GC15P100082
  • GC15P100163
  • GC15P102345
  • GC15P101805
  • GC15P104702
  • GC15P104768
  • GC15P104812
  • GC15P104115
  • GC15P104306
  • GC15P104483
  • GC15P104636

Summaries for OR4F6 Gene

Entrez Gene Summary for OR4F6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F6 Gene

OR4F6 (Olfactory Receptor Family 4 Subfamily F Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F15.

UniProtKB/Swiss-Prot Summary for OR4F6 Gene

Gene Wiki entry for OR4F6 Gene

Additional gene information for OR4F6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4F6 Gene

Genomics for OR4F6 Gene

GeneHancer (GH) Regulatory Elements for OR4F6 Gene

Promoters and enhancers for OR4F6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J101770 Enhancer 0.4 Ensembl 11.4 -32.7 -32708 0.4 CEBPG TOE1 ATF4 ATF3 LOC105371030 piR-36819-002 piR-39812-003 piR-33451-002 piR-33639 piR-37484 piR-37617-005 piR-31702 piR-31784 piR-33942
GH15J101827 Enhancer 0.2 ENCODE 12 +24.1 24101 0.7 OR4F14P OR4F6 LOC100128108 OR4F15 lnc-OR4F15-5
GH15J101405 Enhancer 0.2 FANTOM5 2.4 -397.8 -397811 0 PCSK6 OR4F6 OR4F15 RF00017-1913 piR-33077 LOC100507472
GH15J101397 Enhancer 0.2 FANTOM5 1.8 -406.0 -405968 0.1 RNU6-807P PCSK6 OR4F6 OR4F15 TM2D3 RF00017-1913 lnc-SNRPA1-2 LOC100507472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4F6

Top Transcription factor binding sites by QIAGEN in the OR4F6 gene promoter:
  • AREB6
  • c-Rel
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • S8

Genomic Locations for OR4F6 Gene

Genomic Locations for OR4F6 Gene
chr15:101,803,509-101,806,887
(GRCh38/hg38)
Size:
3,379 bases
Orientation:
Plus strand
chr15:102,345,902-102,346,876
(GRCh37/hg19)
Size:
975 bases
Orientation:
Plus strand

Genomic View for OR4F6 Gene

Genes around OR4F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F6 Gene

Proteins for OR4F6 Gene

  • Protein details for OR4F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB9-OR4F6_HUMAN
    Recommended name:
    Olfactory receptor 4F6
    Protein Accession:
    Q8NGB9
    Secondary Accessions:
    • B9EH28
    • Q6IF95

    Protein attributes for OR4F6 Gene

    Size:
    312 amino acids
    Molecular mass:
    35355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F6 Gene

Post-translational modifications for OR4F6 Gene

  • Glycosylation at Asn5

Other Protein References for OR4F6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F6 Gene

Domains & Families for OR4F6 Gene

Gene Families for OR4F6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F6 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR4F6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR15-15 (OR4F6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGB9

UniProtKB/Swiss-Prot:

OR4F6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F6: view

Function for OR4F6 Gene

Molecular function for OR4F6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F6: view
genes like me logo Genes that share phenotypes with OR4F6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F6 Gene

Localization for OR4F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F6 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4F6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F6 Gene

Pathways & Interactions for OR4F6 Gene

genes like me logo Genes that share pathways with OR4F6: view

Pathways by source for OR4F6 Gene

Interacting Proteins for OR4F6 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000327525 Q8NGB9-OR4F6_HUMAN for OR4F6 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F6: view

No data available for SIGNOR curated interactions for OR4F6 Gene

Drugs & Compounds for OR4F6 Gene

No Compound Related Data Available

Transcripts for OR4F6 Gene

mRNA/cDNA for OR4F6 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F6 Gene

No ASD Table

Relevant External Links for OR4F6 Gene

GeneLoc Exon Structure for
OR4F6

Expression for OR4F6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4F6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4F6

SOURCE GeneReport for Unigene cluster for OR4F6 Gene:

Hs.553399
genes like me logo Genes that share expression patterns with OR4F6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F6 Gene

Orthologs for OR4F6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC467782 30
  • 99.25 (n)
OR4F6 31
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or4f6 47 Olfr1310 17 31 30
  • 82.74 (n)
Or4f52 47 Olfr1275
  • chr2:111,230,856-111,231,791
Or4f58 47 Olfr1311
  • chr2:112,020,917-112,022,062
rat
(Rattus norvegicus)
Mammalia Olr783 30
  • 82.1 (n)
cow
(Bos Taurus)
Mammalia LOC504344 30
  • 78.14 (n)
-- 31
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 60 (a)
ManyToMany
Species where no ortholog for OR4F6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F6 Gene

ENSEMBL:
Gene Tree for OR4F6 (if available)
TreeFam:
Gene Tree for OR4F6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4F6: view image

Paralogs for OR4F6 Gene

(431) SIMAP similar genes for OR4F6 Gene using alignment to 1 proteins:

  • OR4F6_HUMAN
genes like me logo Genes that share paralogs with OR4F6: view

Variants for OR4F6 Gene

Additional dbSNP identifiers (rs#s) for OR4F6 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR4F6 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV gain 17911159
dgv2677n100 CNV loss 25217958
dgv2683n100 CNV gain 25217958
dgv2684n100 CNV gain 25217958
dgv2685n100 CNV gain 25217958
dgv470e214 CNV gain 21293372
dgv4801n54 CNV gain 21841781
dgv4802n54 CNV gain 21841781
dgv766e212 CNV gain 25503493
dgv767e212 CNV loss 25503493
esv2751291 CNV gain 17911159
esv2760064 CNV gain 17122850
esv2760373 CNV gain 21179565
esv2761688 CNV gain+loss 21179565
esv3581886 CNV loss 25503493
esv3637524 CNV loss 21293372
esv3637525 CNV gain 21293372
esv3892749 CNV gain 25118596
nsv1036552 CNV gain 25217958
nsv1040586 CNV gain 25217958
nsv1041586 CNV gain 25217958
nsv1052710 CNV gain 25217958
nsv1054517 CNV loss 25217958
nsv469527 CNV loss 16826518
nsv469708 CNV gain 16826518
nsv519940 CNV gain 19592680
nsv524612 CNV loss 19592680
nsv570915 CNV loss 21841781
nsv570916 CNV gain 21841781

Variation tolerance for OR4F6 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4F6 Gene

Disorders for OR4F6 Gene

Additional Disease Information for OR4F6

No disorders were found for OR4F6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F6 Gene

Publications for OR4F6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. (PMID: 12507995) Brock C … Nürnberg B (The Journal of cell biology 2003) 3 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for OR4F6 Gene

Sources for OR4F6 Gene