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Aliases for OR4F6 Gene

Aliases for OR4F6 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 6 2 3 5
  • Olfactory Receptor, Family 4, Subfamily F, Member 12 2 3
  • Olfactory Receptor OR15-15 3 4
  • Olfactory Receptor 4F12 3 4
  • OR4F12 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 6 2
  • Olfactory Receptor 4F6 3
  • OR15-15 3

External Ids for OR4F6 Gene

Previous HGNC Symbols for OR4F6 Gene

  • OR4F12

Previous GeneCards Identifiers for OR4F6 Gene

  • GC15U990132
  • GC15P100082
  • GC15P100163
  • GC15P102345
  • GC15P101805
  • GC15P104115
  • GC15P104306

Summaries for OR4F6 Gene

Entrez Gene Summary for OR4F6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F6 Gene

OR4F6 (Olfactory Receptor Family 4 Subfamily F Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F15.

UniProtKB/Swiss-Prot for OR4F6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4F6 Gene

Additional gene information for OR4F6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F6 Gene

Genomics for OR4F6 Gene

GeneHancer (GH) Regulatory Elements for OR4F6 Gene

Promoters and enhancers for OR4F6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J101827 Enhancer 0.2 ENCODE 12 +24.1 24101 0.7 OR4F14P OR4F6 LOC100128108 GC15P104789
GH15J101405 Enhancer 0.2 FANTOM5 2.4 -397.8 -397811 0 PCSK6 OR4F6 OR4F15 PIR54076 PCSK6-AS1
GH15J101397 Enhancer 0.2 FANTOM5 1.8 -406.0 -405968 0.1 RNU6-807P PCSK6 OR4F6 OR4F15 TM2D3 PIR54076 PCSK6-AS1
GH15J101807 Enhancer 0.4 ENCODE 0.7 +4.5 4511 1.8 ZSCAN5C FOS LOC100128108 WASH3P OR4F6 OR4F15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4F6 gene promoter:
  • AREB6
  • FOXJ2 (long isoform)
  • FOXJ2
  • FOXL1
  • Evi-1
  • c-Rel
  • FOXO3b
  • S8
  • FOXO3
  • FOXO3a

Genomic Locations for OR4F6 Gene

Genomic Locations for OR4F6 Gene
chr15:101,803,509-101,806,887
(GRCh38/hg38)
Size:
3,379 bases
Orientation:
Plus strand
chr15:102,345,902-102,346,876
(GRCh37/hg19)
Size:
975 bases
Orientation:
Plus strand

Genomic View for OR4F6 Gene

Genes around OR4F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F6 Gene

Proteins for OR4F6 Gene

  • Protein details for OR4F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB9-OR4F6_HUMAN
    Recommended name:
    Olfactory receptor 4F6
    Protein Accession:
    Q8NGB9
    Secondary Accessions:
    • B9EH28
    • Q6IF95

    Protein attributes for OR4F6 Gene

    Size:
    312 amino acids
    Molecular mass:
    35355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F6 Gene

Post-translational modifications for OR4F6 Gene

Other Protein References for OR4F6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F6 Gene

Domains & Families for OR4F6 Gene

Gene Families for OR4F6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F6 Gene

Suggested Antigen Peptide Sequences for OR4F6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGB9

UniProtKB/Swiss-Prot:

OR4F6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F6: view

Function for OR4F6 Gene

Molecular function for OR4F6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F6: view
genes like me logo Genes that share phenotypes with OR4F6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F6 Gene

Localization for OR4F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F6 Gene

Pathways & Interactions for OR4F6 Gene

genes like me logo Genes that share pathways with OR4F6: view

Pathways by source for OR4F6 Gene

Interacting Proteins for OR4F6 Gene

Gene Ontology (GO) - Biological Process for OR4F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4F6: view

No data available for SIGNOR curated interactions for OR4F6 Gene

Drugs & Compounds for OR4F6 Gene

No Compound Related Data Available

Transcripts for OR4F6 Gene

mRNA/cDNA for OR4F6 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4F6 Gene

Olfactory receptor, family 4, subfamily F, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F6 Gene

No ASD Table

Relevant External Links for OR4F6 Gene

GeneLoc Exon Structure for
OR4F6
ECgene alternative splicing isoforms for
OR4F6

Expression for OR4F6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4F6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4F6 Gene:

OR4F6

SOURCE GeneReport for Unigene cluster for OR4F6 Gene:

Hs.553399
genes like me logo Genes that share expression patterns with OR4F6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F6 Gene

Orthologs for OR4F6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC467782 33
  • 99.25 (n)
OR4F6 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or4f6 51 Olfr1310 16 34 33
  • 82.74 (n)
Or4f52 51 Olfr1275
  • chr2:111,230,856-111,231,791
Or4f58 51 Olfr1311
  • chr2:112,020,917-112,022,062
rat
(Rattus norvegicus)
Mammalia Olr783 33
  • 82.1 (n)
cow
(Bos Taurus)
Mammalia LOC504344 33
  • 78.14 (n)
-- 34
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 60 (a)
ManyToMany
Species where no ortholog for OR4F6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F6 Gene

ENSEMBL:
Gene Tree for OR4F6 (if available)
TreeFam:
Gene Tree for OR4F6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4F6: view image

Paralogs for OR4F6 Gene

Paralogs for OR4F6 Gene

(431) SIMAP similar genes for OR4F6 Gene using alignment to 1 proteins:

  • OR4F6_HUMAN
genes like me logo Genes that share paralogs with OR4F6: view

Variants for OR4F6 Gene

Sequence variations from dbSNP and Humsavar for OR4F6 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000022427 -- 101,803,855(+) GAG/G upstream_transcript_variant
rs1000427828 -- 101,804,291(+) C/A/T upstream_transcript_variant
rs1001582071 -- 101,803,776(+) C/T upstream_transcript_variant
rs1001697450 -- 101,805,318(+) G/A upstream_transcript_variant
rs1001812200 -- 101,805,625(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4F6 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV gain 17911159
dgv2677n100 CNV loss 25217958
dgv2683n100 CNV gain 25217958
dgv2684n100 CNV gain 25217958
dgv2685n100 CNV gain 25217958
dgv470e214 CNV gain 21293372
dgv4801n54 CNV gain 21841781
dgv4802n54 CNV gain 21841781
dgv766e212 CNV gain 25503493
dgv767e212 CNV loss 25503493
esv2751291 CNV gain 17911159
esv2760064 CNV gain 17122850
esv2760373 CNV gain 21179565
esv2761688 CNV gain+loss 21179565
esv3581886 CNV loss 25503493
esv3637524 CNV loss 21293372
esv3637525 CNV gain 21293372
esv3892749 CNV gain 25118596
nsv1036552 CNV gain 25217958
nsv1040586 CNV gain 25217958
nsv1041586 CNV gain 25217958
nsv1052710 CNV gain 25217958
nsv1054517 CNV loss 25217958
nsv469527 CNV loss 16826518
nsv469708 CNV gain 16826518
nsv519940 CNV gain 19592680
nsv524612 CNV loss 19592680
nsv570915 CNV loss 21841781
nsv570916 CNV gain 21841781

Variation tolerance for OR4F6 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F6 Gene

Disorders for OR4F6 Gene

Additional Disease Information for OR4F6

No disorders were found for OR4F6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F6 Gene

Publications for OR4F6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. (PMID: 12507995) Brock C … Nürnberg B (The Journal of cell biology 2003) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. (PMID: 10358071) Krugmann S … Braselmann S (The Journal of biological chemistry 1999) 3 58

Products for OR4F6 Gene

Sources for OR4F6 Gene

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