Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4F5 Gene

Aliases for OR4F5 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 5 2 3 5
  • Olfactory Receptor 4F5 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 5 2
  • OR4F5 5

External Ids for OR4F5 Gene

Previous GeneCards Identifiers for OR4F5 Gene

  • GC07U990300
  • GC01U901109
  • GC01P000059

Summaries for OR4F5 Gene

Entrez Gene Summary for OR4F5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F5 Gene

OR4F5 (Olfactory Receptor Family 4 Subfamily F Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F17.

UniProtKB/Swiss-Prot Summary for OR4F5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4F5 Gene

Genomics for OR4F5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4F5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J000108 Enhancer 0.5 Ensembl 0.2 +50.5 50482 0.2 NCOR1 TCF12 DPF2 ARID1B CBFA2T2 CBFA2T3 piR-30200-001 SEPTIN14P18 ENSG00000238009 OR4F5 lnc-OR4F29-11 LOC100996442 HSALNG0023753-001 OR4F29
GH01J000028 Promoter 0.3 Ensembl 0.3 -36.4 -36418 2.8 MIR1302-2 MIR1302-2HG WASH7P piR-45330-001 OR4F5 lnc-OR4F29-11
GH01J000049 Enhancer 0.2 Ensembl 0.4 -9.2 -9218 0.8 OR4G11P HSALNG0000008 OR4F5 lnc-OR4F29-11
GH01J000137 Promoter 0.3 Ensembl 0.2 +73.0 72982 0.8 ENSG00000239906 ENSG00000269981 piR-41282-001 piR-38653-001 piR-42618-001 piR-42757-001 piR-36473-001 piR-36879-001 piR-44522-001 piR-43130-001
GH01J000033 Enhancer 0.2 Ensembl 0.3 -28.3 -28279 6.5 FAM138A HSALNG0000006-001 lnc-OR4F29-10 OR4F5 lnc-OR4F29-11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4F5

Top Transcription factor binding sites by QIAGEN in the OR4F5 gene promoter:
  • AML1a
  • AP-1
  • CUTL1
  • GATA-1
  • HNF-1
  • HNF-1A
  • Sox9
  • SRY

Genomic Locations for OR4F5 Gene

Latest Assembly
chr1:65,419-71,585
(GRCh38/hg38)
Size:
6,167 bases
Orientation:
Plus strand

Previous Assembly
chr1:65,419-71,585
(GRCh37/hg19 by Entrez Gene)
Size:
6,167 bases
Orientation:
Plus strand

chr1:69,091-70,008
(GRCh37/hg19 by Ensembl)
Size:
918 bases
Orientation:
Plus strand

Genomic View for OR4F5 Gene

Genes around OR4F5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F5 Gene

Proteins for OR4F5 Gene

  • Protein details for OR4F5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH21-OR4F5_HUMAN
    Recommended name:
    Olfactory receptor 4F5
    Protein Accession:
    Q8NH21
    Secondary Accessions:
    • Q5VT22

    Protein attributes for OR4F5 Gene

    Size:
    305 amino acids
    Molecular mass:
    34330 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F5 Gene

Post-translational modifications for OR4F5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4F5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F5 Gene

Domains & Families for OR4F5 Gene

Gene Families for OR4F5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4F5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 4F5 (OR4F5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH21

UniProtKB/Swiss-Prot:

OR4F5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F5: view

Function for OR4F5 Gene

Molecular function for OR4F5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F5: view

Phenotypes for OR4F5 Gene

genes like me logo Genes that share phenotypes with OR4F5: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F5

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F5 Gene

Localization for OR4F5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4F5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F5 Gene

Pathways & Interactions for OR4F5 Gene

genes like me logo Genes that share pathways with OR4F5: view

Pathways by source for OR4F5 Gene

Interacting Proteins for OR4F5 Gene

Gene Ontology (GO) - Biological Process for OR4F5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F5: view

No data available for SIGNOR curated interactions for OR4F5 Gene

Drugs & Compounds for OR4F5 Gene

No Compound Related Data Available

Transcripts for OR4F5 Gene

mRNA/cDNA for OR4F5 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F5

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F5 Gene

No ASD Table

Relevant External Links for OR4F5 Gene

GeneLoc Exon Structure for
OR4F5

Expression for OR4F5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4F5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4F5

SOURCE GeneReport for Unigene cluster for OR4F5 Gene:

Hs.554500
genes like me logo Genes that share expression patterns with OR4F5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F5 Gene

Orthologs for OR4F5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100608733 29
  • 99.13 (n)
-- 30
  • 81 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC785647 29
  • 88.01 (n)
-- 30
  • 77 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr765 29
  • 83.28 (n)
Mouse
(Mus musculus)
Mammalia Olfr1289 30
  • 81 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 55 (a)
ManyToMany
Species where no ortholog for OR4F5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4F5 Gene

ENSEMBL:
Gene Tree for OR4F5 (if available)
TreeFam:
Gene Tree for OR4F5 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4F5

Paralogs for OR4F5 Gene

(444) SIMAP similar genes for OR4F5 Gene using alignment to 1 proteins:

  • OR4F5_HUMAN

Pseudogenes.org Pseudogenes for OR4F5 Gene

genes like me logo Genes that share paralogs with OR4F5: view

Variants for OR4F5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4F5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4F5 Gene

Variant ID Type Subtype PubMed ID
dgv1n54 CNV loss 21841781
esv27265 CNV gain+loss 19812545
nsv1076307 CNV duplication 25765185
nsv428112 CNV gain 18775914
nsv437198 CNV loss 16327808
nsv437859 CNV loss 16468122
nsv469759 CNV gain 16826518
nsv471591 CNV loss 15918152
nsv482937 CNV loss 15286789
nsv514929 CNV gain 21397061
nsv544867 CNV gain+loss 21841781
nsv7879 CNV gain+loss 18304495
nsv951399 CNV duplication 24416366

Variation tolerance for OR4F5 Gene

Gene Damage Index Score: 2.32; 41.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F5 Gene

Human Gene Mutation Database (HGMD)
OR4F5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F5
Leiden Open Variation Database (LOVD)
OR4F5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4F5 Gene

Disorders for OR4F5 Gene

Additional Disease Information for OR4F5

No disorders were found for OR4F5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F5 Gene

Publications for OR4F5 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. (PMID: 32126975) Barnes IHA … Frankish A (BMC genomics 2020) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4F5 Gene

Sources for OR4F5 Gene