Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4F4 Gene

Aliases for OR4F4 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 4 2 3 5
  • Olfactory Receptor OR19-3 3 4
  • Olfactory Receptor 4F4 3 4
  • HS14a-1-A 3 4
  • OR4F18 2 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 18 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 4 2
  • OLA-7501 3
  • OR4F17 3
  • OR4F4 5

External Ids for OR4F4 Gene

Previous GeneCards Identifiers for OR4F4 Gene

  • GC02U990131
  • GC15U900440
  • GC19P000062
  • GC15M100279
  • GC15M102462

Summaries for OR4F4 Gene

Entrez Gene Summary for OR4F4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F4 Gene

OR4F4 (Olfactory Receptor Family 4 Subfamily F Member 4) is a Protein Coding gene. Diseases associated with OR4F4 include Pseudobulbar Palsy. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F17.

UniProtKB/Swiss-Prot Summary for OR4F4 Gene

Gene Wiki entry for OR4F4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4F4 Gene

Genomics for OR4F4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4F4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J101961 Promoter 0.8 Ensembl 0.3 -38.7 -38688 3.2 ELF1 THRAP3 SUPT5H TOE1 ZBTB40 ZFP36 MNT GABPB1 NBN MLLT1 ENSG00000259553 MIR1302-10 WASH3P lnc-OR4F15-4 piR-45330-004 OR4F4
GH15J101955 Enhancer 0.6 ENCODE 0.3 -32.8 -32801 0.5 ZNF592 TAF9B IRF9 SUPT5H SMARCA4 POLR2A L3MBTL2 NR2C1 GTF2F1 NFRKB FAM138E HSALNG0108678 HSALNG0108677 piR-35049-004 OR4F4
GH15J101954 Promoter 0.6 Ensembl 0.3 -31.0 -30988 0.6 SUPT5H POLR2A ZC3H8 FAM138E HSALNG0108677 HSALNG0108678 OR4F4
GH15J101953 Promoter 0.3 EPDnew 0.3 -31.8 -31754 0.1 FAM138E HSALNG0108678 HSALNG0108677 OR4F4
GH15J101934 Enhancer 0.2 Ensembl 0.4 -11.6 -11588 0.6 OR4G2P HSALNG0108676 OR4F4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4F4

Top Transcription factor binding sites by QIAGEN in the OR4F4 gene promoter:
  • AML1a
  • CUTL1
  • GATA-1
  • POU2F1
  • POU2F1a
  • RORalpha1
  • Sox9
  • SRY

Genomic Locations for OR4F4 Gene

Latest Assembly
chr15:101,922,042-101,923,113
(GRCh38/hg38)
Size:
1,072 bases
Orientation:
Minus strand

Previous Assembly
chr15:102,462,345-102,463,262
(GRCh37/hg19 by Entrez Gene)
Size:
918 bases
Orientation:
Minus strand

chr15:102,462,245-102,463,298
(GRCh37/hg19 by Ensembl)
Size:
1,054 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr15(PATCHES):28,279-29,196 (-)

Genomic View for OR4F4 Gene

Genes around OR4F4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F4 Gene

Proteins for OR4F4 Gene

  • Protein details for OR4F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R69-OR4F4_HUMAN
    Recommended name:
    Olfactory receptor 4F4
    Protein Accession:
    Q96R69
    Secondary Accessions:
    • B2RNI5
    • Q6IFN9

    Protein attributes for OR4F4 Gene

    Size:
    305 amino acids
    Molecular mass:
    34259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F4 Gene

Post-translational modifications for OR4F4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4F4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F4 Gene

Domains & Families for OR4F4 Gene

Gene Families for OR4F4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4F4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-3 (OR4F4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96R69

UniProtKB/Swiss-Prot:

OR4F4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F4: view

Function for OR4F4 Gene

Molecular function for OR4F4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F4: view

Phenotypes for OR4F4 Gene

GenomeRNAi human phenotypes for OR4F4:
genes like me logo Genes that share phenotypes with OR4F4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F4 Gene

Localization for OR4F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4F4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F4 Gene

Pathways & Interactions for OR4F4 Gene

genes like me logo Genes that share pathways with OR4F4: view

Pathways by source for OR4F4 Gene

Interacting Proteins for OR4F4 Gene

Gene Ontology (GO) - Biological Process for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F4: view

No data available for SIGNOR curated interactions for OR4F4 Gene

Drugs & Compounds for OR4F4 Gene

No Compound Related Data Available

Transcripts for OR4F4 Gene

mRNA/cDNA for OR4F4 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F4

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F4 Gene

No ASD Table

Relevant External Links for OR4F4 Gene

GeneLoc Exon Structure for
OR4F4

Expression for OR4F4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4F4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4F4

SOURCE GeneReport for Unigene cluster for OR4F4 Gene:

Hs.554420
genes like me logo Genes that share expression patterns with OR4F4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F4 Gene

Orthologs for OR4F4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100608733 29
  • 99.56 (n)
Cow
(Bos Taurus)
Mammalia LOC785647 29
  • 88.45 (n)
-- 30
  • 78 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr765 29
  • 83.5 (n)
Mouse
(Mus musculus)
Mammalia Or4f4b 45 Olfr1289 30
  • 82 (a)
OneToMany
Or4f4-ps 45 Olfr1291-ps1
  • chr2:111,499,302-111,500,231
Or4f55 45 Olfr1283
  • chr2:111,368,634-111,369,548
Or4k36 45 Olfr1280
  • chr2:111,315,481-111,316,395
Or4k41 45 Olfr1287
  • chr2:111,449,142-111,450,056
Or4k50-ps 45 Olfr1300-ps1
  • chr2:111,691,520-111,692,453
Or4k52 45 Olfr1302
  • chr2:111,780,313-111,781,257
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 56 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 54 (a)
ManyToMany
Species where no ortholog for OR4F4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4F4 Gene

ENSEMBL:
Gene Tree for OR4F4 (if available)
TreeFam:
Gene Tree for OR4F4 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4F4

Paralogs for OR4F4 Gene

(442) SIMAP similar genes for OR4F4 Gene using alignment to 1 proteins:

  • OR4F4_HUMAN

Pseudogenes.org Pseudogenes for OR4F4 Gene

genes like me logo Genes that share paralogs with OR4F4: view

Variants for OR4F4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4F4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4F4 Gene

Variant ID Type Subtype PubMed ID
dgv1278n106 CNV duplication 24896259
dgv453n67 CNV gain 20364138
dgv4801n54 CNV gain 21841781
dgv4803n54 CNV loss 21841781
esv27561 CNV gain 19812545
esv2760373 CNV gain 21179565
esv2761688 CNV gain+loss 21179565
esv3358535 CNV duplication 20981092
esv3892752 CNV loss 25118596
nsv1147785 CNV duplication 26484159
nsv471523 CNV gain 19718026
nsv511553 CNV loss 21212237
nsv570922 CNV loss 21841781
nsv820527 CNV duplication 20802225
nsv9315 CNV gain+loss 18304495
nsv952892 CNV duplication 24416366

Variation tolerance for OR4F4 Gene

Gene Damage Index Score: 1.59; 30.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F4
Leiden Open Variation Database (LOVD)
OR4F4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4F4 Gene

Disorders for OR4F4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR4F4 Gene - From: COP

Disorder Aliases PubMed IDs
pseudobulbar palsy
  • pseudobulbar paralysis
- elite association - COSMIC cancer census association via MalaCards
Search OR4F4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR4F4

genes like me logo Genes that share disorders with OR4F4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4F4 Gene

Publications for OR4F4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. (PMID: 9384599) Trask BJ … van den Engh G (Human molecular genetics 1998) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR4F4 Gene

Sources for OR4F4 Gene