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Aliases for OR4F4 Gene

Aliases for OR4F4 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 4 2 3 5
  • Olfactory Receptor OR19-3 3 4
  • HS14a-1-A 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 18 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 4 2
  • Olfactory Receptor 4F4 3
  • OLA-7501 3
  • OR4F17 3
  • OR4F18 3

External Ids for OR4F4 Gene

Previous GeneCards Identifiers for OR4F4 Gene

  • GC02U990131
  • GC15U900440
  • GC19P000062
  • GC15M100279
  • GC15M102462

Summaries for OR4F4 Gene

Entrez Gene Summary for OR4F4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F4 Gene

OR4F4 (Olfactory Receptor Family 4 Subfamily F Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F17.

UniProtKB/Swiss-Prot for OR4F4 Gene

  • Odorant receptor.

Gene Wiki entry for OR4F4 Gene

Additional gene information for OR4F4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F4 Gene

Genomics for OR4F4 Gene

GeneHancer (GH) Regulatory Elements for OR4F4 Gene

Top Transcription factor binding sites by QIAGEN in the OR4F4 gene promoter:
  • GATA-1
  • Sox9
  • AML1a
  • CUTL1
  • SRY
  • POU2F1a
  • POU2F1
  • RORalpha1

Genomic Locations for OR4F4 Gene

Genomic Locations for OR4F4 Gene
1,054 bases
Minus strand
1,054 bases
Minus strand

Genomic View for OR4F4 Gene

Genes around OR4F4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F4 Gene

Proteins for OR4F4 Gene

  • Protein details for OR4F4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4F4
    Protein Accession:
    Secondary Accessions:
    • B2RNI5
    • Q6IFN9

    Protein attributes for OR4F4 Gene

    305 amino acids
    Molecular mass:
    34259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F4 Gene

Post-translational modifications for OR4F4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR4F4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F4 Gene

Domains & Families for OR4F4 Gene

Gene Families for OR4F4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F4 Gene

Suggested Antigen Peptide Sequences for OR4F4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F4: view

Function for OR4F4 Gene

Molecular function for OR4F4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F4: view

Phenotypes for OR4F4 Gene

genes like me logo Genes that share phenotypes with OR4F4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F4 Gene

Localization for OR4F4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F4 Gene

Pathways & Interactions for OR4F4 Gene

genes like me logo Genes that share pathways with OR4F4: view

Pathways by source for OR4F4 Gene

Interacting Proteins for OR4F4 Gene

Gene Ontology (GO) - Biological Process for OR4F4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4F4: view

No data available for SIGNOR curated interactions for OR4F4 Gene

Drugs & Compounds for OR4F4 Gene

No Compound Related Data Available

Transcripts for OR4F4 Gene

mRNA/cDNA for OR4F4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4F4 Gene

Olfactory receptor, family 4, subfamily F, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F4

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F4 Gene

No ASD Table

Relevant External Links for OR4F4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4F4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4F4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4F4 Gene:


SOURCE GeneReport for Unigene cluster for OR4F4 Gene:

genes like me logo Genes that share expression patterns with OR4F4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F4 Gene

Orthologs for OR4F4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608733 33
  • 99.56 (n)
(Bos Taurus)
Mammalia LOC785647 33
  • 88.45 (n)
-- 34
  • 78 (a)
(Rattus norvegicus)
Mammalia Olr765 33
  • 83.5 (n)
(Mus musculus)
Mammalia Or4f4b 51 Olfr1289 34
  • 82 (a)
Or4f4-ps 51 Olfr1291-ps1
  • chr2:111,499,302-111,500,231
Or4f55 51 Olfr1283
  • chr2:111,368,634-111,369,548
Or4k36 51 Olfr1280
  • chr2:111,315,481-111,316,395
Or4k41 51 Olfr1287
  • chr2:111,449,142-111,450,056
Or4k50-ps 51 Olfr1300-ps1
  • chr2:111,691,520-111,692,453
Or4k52 51 Olfr1302
  • chr2:111,780,313-111,781,257
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
(Canis familiaris)
Mammalia -- 34
  • 54 (a)
Species where no ortholog for OR4F4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F4 Gene

Gene Tree for OR4F4 (if available)
Gene Tree for OR4F4 (if available)

Paralogs for OR4F4 Gene

Paralogs for OR4F4 Gene

(442) SIMAP similar genes for OR4F4 Gene using alignment to 1 proteins:

  • OR4F4_HUMAN Pseudogenes for OR4F4 Gene

genes like me logo Genes that share paralogs with OR4F4: view

Variants for OR4F4 Gene

Sequence variations from dbSNP and Humsavar for OR4F4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1005661815 -- 101,921,844(-) C/T downstream_transcript_variant
rs1010067302 -- 101,924,560(-) G/A upstream_transcript_variant
rs1014262494 -- 101,922,995(-) A/C coding_sequence_variant, missense_variant
rs1014377085 -- 101,924,173(-) GGG/G upstream_transcript_variant
rs1016105154 -- 101,922,028(-) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4F4 Gene

Variant ID Type Subtype PubMed ID
dgv1278n106 CNV duplication 24896259
dgv453n67 CNV gain 20364138
dgv4801n54 CNV gain 21841781
dgv4803n54 CNV loss 21841781
esv27561 CNV gain 19812545
esv2760373 CNV gain 21179565
esv2761688 CNV gain+loss 21179565
esv3358535 CNV duplication 20981092
esv3892752 CNV loss 25118596
nsv1147785 CNV duplication 26484159
nsv471523 CNV gain 19718026
nsv511553 CNV loss 21212237
nsv570922 CNV loss 21841781
nsv820527 CNV duplication 20802225
nsv9315 CNV gain+loss 18304495
nsv952892 CNV duplication 24416366

Variation tolerance for OR4F4 Gene

Gene Damage Index Score: 1.59; 30.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F4 Gene

Disorders for OR4F4 Gene

Additional Disease Information for OR4F4

No disorders were found for OR4F4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F4 Gene

Publications for OR4F4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. (PMID: 9384599) Trask BJ … van den Engh G (Human molecular genetics 1998) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR4F4 Gene

Sources for OR4F4 Gene

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