Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4F29 Gene

Aliases for OR4F29 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 29 2 3 5
  • Olfactory Receptor 4F3/4F16/4F29 3 4
  • Olfactory Receptor OR1-1 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 29 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor OR7-21 3
  • OR7-21 3
  • OR4F29 5

External Ids for OR4F29 Gene

Previous GeneCards Identifiers for OR4F29 Gene

  • GC01U901018
  • GC01P000411
  • GC01P000367
  • GC01M000451
  • GC01M000475
  • GC01M001398

Summaries for OR4F29 Gene

Entrez Gene Summary for OR4F29 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F29 Gene

OR4F29 (Olfactory Receptor Family 4 Subfamily F Member 29) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F16.

UniProtKB/Swiss-Prot Summary for OR4F29 Gene

Additional gene information for OR4F29 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4F29 Gene

Genomics for OR4F29 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4F29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J000450 Enhancer 0.2 Ensembl 250.7 +0.8 777 0.2 OR4F29 piR-40110-001 lnc-METRNL-10 LOC112268260 LOC100132287 ENSG00000237094 OR4F5
GH01J000413 Enhancer 0.2 Ensembl 0.3 +37.2 37177 1.4 piR-39182-003 HSALNG0023753-001 OR4F29 lnc-METRNL-10 LOC112268260 LOC100132287 ENSG00000237094 OR4F5
GH01J000272 Promoter 0.6 Ensembl 0.1 +178.0 177977 1.4 ZNF316 MAFK EMSY HSALNG0010917-002 HSALNG0023753-002 RPL23AP21 HSALNG0023753-001 OR4F29 OR4F5
GH01J000391 Enhancer 0.2 Ensembl 0.2 +57.0 56978 1 HSALNG0010917-003 HSALNG0023753-001 lnc-OR4F5-12 OR4F29 lnc-METRNL-10 LOC112268260 LOC100132287 ENSG00000237094 OR4F5
GH01J000385 Enhancer 0.2 Ensembl 0.2 +65.8 65777 0.2 lnc-OR4F5-12 HSALNG0010917-003 HSALNG0023753-001 OR4F29 lnc-METRNL-10 LOC112268260 LOC100132287 ENSG00000237094 OR4F5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F29 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4F29

Top Transcription factor binding sites by QIAGEN in the OR4F29 gene promoter:
  • E47
  • E4BP4
  • FOXL1
  • Hand1
  • HTF
  • Meis-1b
  • Pax-4a
  • POU3F1
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4F29 Gene

Latest Assembly
chr1:450,740-451,678
(GRCh38/hg38)
Size:
939 bases
Orientation:
Minus strand

Previous Assembly
chr1:367,659-368,597
(GRCh37/hg19 by Entrez Gene)
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR4F29 Gene

Genes around OR4F29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F29 Gene

Proteins for OR4F29 Gene

  • Protein details for OR4F29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IEY1-OR4F3_HUMAN
    Recommended name:
    Olfactory receptor 4F3/4F16/4F29
    Protein Accession:
    Q6IEY1
    Secondary Accessions:
    • B2RPQ6

    Protein attributes for OR4F29 Gene

    Size:
    312 amino acids
    Molecular mass:
    35074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F29 Gene

Post-translational modifications for OR4F29 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4F29 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F29 Gene

Domains & Families for OR4F29 Gene

Gene Families for OR4F29 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F29 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4F29 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR1-1 (OR4F3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IEY1

UniProtKB/Swiss-Prot:

OR4F3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F29: view

Function for OR4F29 Gene

Molecular function for OR4F29 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4F29 Gene

Gene Ontology (GO) - Molecular Function for OR4F29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with OR4F29: view

Phenotypes for OR4F29 Gene

GenomeRNAi human phenotypes for OR4F29:
genes like me logo Genes that share phenotypes with OR4F29: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F29 Gene

Localization for OR4F29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F29 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F29 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4F29: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F29 Gene

Pathways & Interactions for OR4F29 Gene

genes like me logo Genes that share pathways with OR4F29: view

Pathways by source for OR4F29 Gene

Interacting Proteins for OR4F29 Gene

Gene Ontology (GO) - Biological Process for OR4F29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F29: view

No data available for SIGNOR curated interactions for OR4F29 Gene

Drugs & Compounds for OR4F29 Gene

No Compound Related Data Available

Transcripts for OR4F29 Gene

mRNA/cDNA for OR4F29 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F29 Gene

No ASD Table

Relevant External Links for OR4F29 Gene

GeneLoc Exon Structure for
OR4F29

Expression for OR4F29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4F29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4F29

genes like me logo Genes that share expression patterns with OR4F29: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F29 Gene

Orthologs for OR4F29 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F29 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC744286 29
  • 99.14 (n)
Rat
(Rattus norvegicus)
Mammalia Olr774 29
  • 82.48 (n)
Mouse
(Mus musculus)
Mammalia Olfr1303 29
  • 82.37 (n)
Dog
(Canis familiaris)
Mammalia cOR4F25 29
  • 78.1 (n)
Cow
(Bos Taurus)
Mammalia LOC788764 29
  • 77.16 (n)
Species where no ortholog for OR4F29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4F29 Gene

ENSEMBL:
Gene Tree for OR4F29 (if available)
TreeFam:
Gene Tree for OR4F29 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4F29

Paralogs for OR4F29 Gene

(435) SIMAP similar genes for OR4F29 Gene using alignment to 1 proteins:

  • OR4F3_HUMAN
genes like me logo Genes that share paralogs with OR4F29: view

Variants for OR4F29 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4F29 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4F29 Gene

Variant ID Type Subtype PubMed ID
dgv1e24 CNV loss 17666407
dgv1n14 CNV gain 18776910
dgv2n14 CNV gain 18776910
dgv5n100 CNV gain 25217958
esv21732 CNV gain+loss 19812545
esv27883 CNV gain+loss 19812545
esv28275 CNV gain+loss 19812545
nsv1003571 CNV loss 25217958
nsv1004962 CNV gain 25217958
nsv10793 CNV gain+loss 18304495
nsv1126162 CNV deletion 24896259
nsv1126737 CNV deletion 24896259
nsv1143424 CNV deletion 24896259
nsv428223 CNV gain+loss 18775914
nsv471442 CNV gain 19718026
nsv471518 CNV gain 19718026
nsv471522 CNV gain 19718026
nsv482937 CNV loss 15286789
nsv514924 CNV gain 21397061
nsv820415 CNV deletion 20802225
nsv829647 CNV gain+loss 17160897
nsv830758 CNV loss 17160897
nsv831869 CNV gain+loss 17160897
nsv945265 OTHER complex 23825009
nsv945736 OTHER complex 23825009
nsv964808 OTHER complex 23825009

Additional Variant Information for OR4F29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F29
Leiden Open Variation Database (LOVD)
OR4F29

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for OR4F29 Gene

Disorders for OR4F29 Gene

Additional Disease Information for OR4F29

No disorders were found for OR4F29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F29 Gene

Publications for OR4F29 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR4F29 Gene

Sources for OR4F29 Gene