Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4F21 Gene

Aliases for OR4F21 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 21 2 3 5
  • Olfactory Receptor 4F21 3 4
  • OR4F21P 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 2
  • OR4F21 5

External Ids for OR4F21 Gene

Previous HGNC Symbols for OR4F21 Gene

  • OR4F21P

Previous GeneCards Identifiers for OR4F21 Gene

  • GC08M000107
  • GC08M000018
  • GC08M000116
  • GC08M000189
  • GC08M000228

Summaries for OR4F21 Gene

Entrez Gene Summary for OR4F21 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F21 Gene

OR4F21 (Olfactory Receptor Family 4 Subfamily F Member 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F29.

UniProtKB/Swiss-Prot Summary for OR4F21 Gene

Additional gene information for OR4F21 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4F21 Gene

Genomics for OR4F21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4F21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J000167 Enhancer 0.2 Ensembl 600.7 +0.9 942 0.2 OR4F21 piR-33863-098
GH08J000212 Enhancer 0.6 Ensembl 0.3 -45.1 -45058 1 EGR1 CEBPB NCOR1 NR2F6 DPF2 TAL1 HDAC2 TCF12 CBFA2T2 CBFA2T3 piR-41937-002 piR-47692 ENSG00000272240 RPL23AP53 ENSG00000273402 piR-41528-002 ZNF596 lnc-OR4F21-1 OR4F21
GH08J000156 Enhancer 0.2 Ensembl 0.4 +10.6 10642 0.4 WBP1LP3 lnc-ZNF596-1 piR-59297-615 OR4F21
GH08J000214 Enhancer 0.3 Ensembl 0.3 -47.7 -47658 1.4 ZSCAN4 piR-41528-002 RPL23AP53 ZNF596 piR-47692 lnc-OR4F21-1 OR4F21
GH08J000217 Enhancer 0.3 Ensembl 0.2 -51.0 -50958 2 ZBTB40 ENSG00000272240 RPL23AP53 piR-41528-002 piR-33804-097 ZNF596 lnc-OR4F21-1 OR4F21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4F21

Top Transcription factor binding sites by QIAGEN in the OR4F21 gene promoter:
  • E4BP4
  • FOXL1
  • HOXA9B
  • HTF
  • Meis-1
  • Meis-1b
  • Pax-4a
  • POU3F1
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4F21 Gene

Genomic Locations for OR4F21 Gene
chr8:166,049-167,043
(GRCh38/hg38)
Size:
995 bases
Orientation:
Minus strand
chr8:116,049-117,043
(GRCh37/hg19)
Size:
995 bases
Orientation:
Minus strand

Genomic View for OR4F21 Gene

Genes around OR4F21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F21 Gene

Proteins for OR4F21 Gene

  • Protein details for OR4F21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95013-O4F21_HUMAN
    Recommended name:
    Olfactory receptor 4F21
    Protein Accession:
    O95013
    Secondary Accessions:
    • A6NIU1

    Protein attributes for OR4F21 Gene

    Size:
    312 amino acids
    Molecular mass:
    35094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F21 Gene

Post-translational modifications for OR4F21 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4F21 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F21 Gene

Domains & Families for OR4F21 Gene

Gene Families for OR4F21 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F21 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR4F21 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 4F21 (O4F21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95013

UniProtKB/Swiss-Prot:

O4F21_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F21: view

Function for OR4F21 Gene

Molecular function for OR4F21 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F21: view
genes like me logo Genes that share phenotypes with OR4F21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F21

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F21 Gene

Localization for OR4F21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F21 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F21 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4F21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F21 Gene

Pathways & Interactions for OR4F21 Gene

genes like me logo Genes that share pathways with OR4F21: view

Pathways by source for OR4F21 Gene

Interacting Proteins for OR4F21 Gene

Gene Ontology (GO) - Biological Process for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F21: view

No data available for SIGNOR curated interactions for OR4F21 Gene

Drugs & Compounds for OR4F21 Gene

No Compound Related Data Available

Transcripts for OR4F21 Gene

mRNA/cDNA for OR4F21 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F21

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F21 Gene

No ASD Table

Relevant External Links for OR4F21 Gene

GeneLoc Exon Structure for
OR4F21

Expression for OR4F21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4F21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4F21

SOURCE GeneReport for Unigene cluster for OR4F21 Gene:

Hs.690459
genes like me logo Genes that share expression patterns with OR4F21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F21 Gene

Orthologs for OR4F21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC744286 30
  • 99.25 (n)
-- 31
  • 97 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToMany
cOR4F25 30
  • 77.99 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 90 (a)
ManyToMany
-- 31
  • 88 (a)
ManyToMany
-- 31
  • 88 (a)
ManyToMany
LOC788764 30
  • 77.06 (n)
Rat
(Rattus norvegicus)
Mammalia Olr774 30
  • 82.37 (n)
Mouse
(Mus musculus)
Mammalia Olfr1303 30 31
  • 82.05 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
Species where no ortholog for OR4F21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4F21 Gene

ENSEMBL:
Gene Tree for OR4F21 (if available)
TreeFam:
Gene Tree for OR4F21 (if available)

Paralogs for OR4F21 Gene

(439) SIMAP similar genes for OR4F21 Gene using alignment to 1 proteins:

  • O4F21_HUMAN
genes like me logo Genes that share paralogs with OR4F21: view

Variants for OR4F21 Gene

Additional dbSNP identifiers (rs#s) for OR4F21 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR4F21 Gene

Variant ID Type Subtype PubMed ID
dgv6788n100 CNV gain 25217958
dgv6789n100 CNV gain 25217958
dgv6790n100 CNV gain 25217958
dgv6791n100 CNV gain 25217958
esv26079 CNV gain+loss 19812545
esv2759581 CNV gain+loss 17122850
esv2761228 CNV gain+loss 21179565
nsv1030422 CNV gain 25217958
nsv1030576 CNV gain 25217958
nsv1031378 CNV loss 25217958
nsv1076028 CNV deletion 25765185
nsv1119154 CNV deletion 24896259
nsv428193 CNV gain+loss 18775914
nsv471521 CNV gain 19718026
nsv515053 CNV gain 21397061
nsv820991 CNV deletion 20802225
nsv8253 CNV gain+loss 18304495
nsv831205 CNV loss 17160897
nsv967513 OTHER complex 23825009

Variation tolerance for OR4F21 Gene

Gene Damage Index Score: 0.70; 14.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4F21 Gene

Disorders for OR4F21 Gene

Additional Disease Information for OR4F21

No disorders were found for OR4F21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F21 Gene

Publications for OR4F21 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4

Products for OR4F21 Gene

Sources for OR4F21 Gene