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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR4F21 (Olfactory Receptor Family 4 Subfamily F Member 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F29.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08J000167 | Enhancer | 0.2 | Ensembl | 600.7 | +0.9 | 942 | 0.2 | OR4F21 piR-33863-098 | ||
GH08J000212 | Enhancer | 0.6 | Ensembl | 0.3 | -45.1 | -45058 | 1 | EGR1 CEBPB NCOR1 NR2F6 DPF2 TAL1 HDAC2 TCF12 CBFA2T2 CBFA2T3 | piR-41937-002 piR-47692 ENSG00000272240 RPL23AP53 ENSG00000273402 piR-41528-002 ZNF596 lnc-OR4F21-1 OR4F21 | |
GH08J000156 | Enhancer | 0.2 | Ensembl | 0.4 | +10.6 | 10642 | 0.4 | WBP1LP3 lnc-ZNF596-1 piR-59297-615 OR4F21 | ||
GH08J000214 | Enhancer | 0.3 | Ensembl | 0.3 | -47.7 | -47658 | 1.4 | ZSCAN4 | piR-41528-002 RPL23AP53 ZNF596 piR-47692 lnc-OR4F21-1 OR4F21 | |
GH08J000217 | Enhancer | 0.3 | Ensembl | 0.2 | -51.0 | -50958 | 2 | ZBTB40 | ENSG00000272240 RPL23AP53 piR-41528-002 piR-33804-097 ZNF596 lnc-OR4F21-1 OR4F21 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC744286 30 |
|
||
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
cOR4F25 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
LOC788764 30 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Olr774 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Olfr1303 30 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6788n100 | CNV | gain | 25217958 |
dgv6789n100 | CNV | gain | 25217958 |
dgv6790n100 | CNV | gain | 25217958 |
dgv6791n100 | CNV | gain | 25217958 |
esv26079 | CNV | gain+loss | 19812545 |
esv2759581 | CNV | gain+loss | 17122850 |
esv2761228 | CNV | gain+loss | 21179565 |
nsv1030422 | CNV | gain | 25217958 |
nsv1030576 | CNV | gain | 25217958 |
nsv1031378 | CNV | loss | 25217958 |
nsv1076028 | CNV | deletion | 25765185 |
nsv1119154 | CNV | deletion | 24896259 |
nsv428193 | CNV | gain+loss | 18775914 |
nsv471521 | CNV | gain | 19718026 |
nsv515053 | CNV | gain | 21397061 |
nsv820991 | CNV | deletion | 20802225 |
nsv8253 | CNV | gain+loss | 18304495 |
nsv831205 | CNV | loss | 17160897 |
nsv967513 | OTHER | complex | 23825009 |
No disorders were found for OR4F21 Gene.