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Aliases for OR4F21 Gene

Aliases for OR4F21 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 21 2 3 5
  • OR4F21P 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily F, Member 21 2
  • Olfactory Receptor 4F21 3

External Ids for OR4F21 Gene

Previous HGNC Symbols for OR4F21 Gene

  • OR4F21P

Previous GeneCards Identifiers for OR4F21 Gene

  • GC08M000107
  • GC08M000018

Summaries for OR4F21 Gene

Entrez Gene Summary for OR4F21 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F21 Gene

OR4F21 (Olfactory Receptor Family 4 Subfamily F Member 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F16.

UniProtKB/Swiss-Prot for OR4F21 Gene

  • Odorant receptor.

Additional gene information for OR4F21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F21 Gene

Genomics for OR4F21 Gene

GeneHancer (GH) Regulatory Elements for OR4F21 Gene

Top Transcription factor binding sites by QIAGEN in the OR4F21 gene promoter:

Genomic Locations for OR4F21 Gene

Genomic Locations for OR4F21 Gene
995 bases
Minus strand

Genomic View for OR4F21 Gene

Genes around OR4F21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F21 Gene

Proteins for OR4F21 Gene

  • Protein details for OR4F21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4F21
    Protein Accession:
    Secondary Accessions:
    • A6NIU1

    Protein attributes for OR4F21 Gene

    312 amino acids
    Molecular mass:
    35094 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F21 Gene

Post-translational modifications for OR4F21 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4F21 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F21 Gene

Domains & Families for OR4F21 Gene

Gene Families for OR4F21 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F21 Gene

Suggested Antigen Peptide Sequences for OR4F21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F21: view

Function for OR4F21 Gene

Molecular function for OR4F21 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F21: view
genes like me logo Genes that share phenotypes with OR4F21: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F21 Gene

Localization for OR4F21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F21 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F21 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F21 Gene

Pathways & Interactions for OR4F21 Gene

genes like me logo Genes that share pathways with OR4F21: view

Pathways by source for OR4F21 Gene

Interacting Proteins for OR4F21 Gene

Gene Ontology (GO) - Biological Process for OR4F21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4F21: view

No data available for SIGNOR curated interactions for OR4F21 Gene

Drugs & Compounds for OR4F21 Gene

No Compound Related Data Available

Transcripts for OR4F21 Gene

mRNA/cDNA for OR4F21 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F21 Gene

No ASD Table

Relevant External Links for OR4F21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4F21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4F21 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4F21 Gene:


SOURCE GeneReport for Unigene cluster for OR4F21 Gene:

genes like me logo Genes that share expression patterns with OR4F21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F21 Gene

Orthologs for OR4F21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC744286 33
  • 99.25 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
cOR4F25 33
  • 77.99 (n)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
-- 34
  • 88 (a)
-- 34
  • 88 (a)
LOC788764 33
  • 77.06 (n)
(Rattus norvegicus)
Mammalia Olr774 33
  • 82.37 (n)
(Mus musculus)
Mammalia Olfr1303 33 34
  • 82.05 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
Species where no ortholog for OR4F21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F21 Gene

Gene Tree for OR4F21 (if available)
Gene Tree for OR4F21 (if available)

Paralogs for OR4F21 Gene

Paralogs for OR4F21 Gene

(439) SIMAP similar genes for OR4F21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4F21: view

Variants for OR4F21 Gene

Sequence variations from dbSNP and Humsavar for OR4F21 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1008794619 -- 167,616(-) A/G upstream_transcript_variant
rs1010748579 -- 166,619(-) T/C coding_sequence_variant, missense_variant
rs1014497226 -- 166,466(-) G/C coding_sequence_variant, missense_variant
rs1018875181 -- 167,626(-) C/G upstream_transcript_variant
rs1027771873 -- 167,713(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4F21 Gene

Variant ID Type Subtype PubMed ID
dgv6788n100 CNV gain 25217958
dgv6789n100 CNV gain 25217958
dgv6790n100 CNV gain 25217958
dgv6791n100 CNV gain 25217958
esv26079 CNV gain+loss 19812545
esv2759581 CNV gain+loss 17122850
esv2761228 CNV gain+loss 21179565
nsv1030422 CNV gain 25217958
nsv1030576 CNV gain 25217958
nsv1031378 CNV loss 25217958
nsv1076028 CNV deletion 25765185
nsv1119154 CNV deletion 24896259
nsv428193 CNV gain+loss 18775914
nsv471521 CNV gain 19718026
nsv515053 CNV gain 21397061
nsv820991 CNV deletion 20802225
nsv8253 CNV gain+loss 18304495
nsv831205 CNV loss 17160897
nsv967513 OTHER complex 23825009

Variation tolerance for OR4F21 Gene

Gene Damage Index Score: 0.70; 14.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4F21 Gene

Disorders for OR4F21 Gene

Additional Disease Information for OR4F21

No disorders were found for OR4F21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F21 Gene

Publications for OR4F21 Gene

  1. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58

Products for OR4F21 Gene

Sources for OR4F21 Gene

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