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Aliases for OR4F16 Gene

Aliases for OR4F16 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 16 2 3 5
  • Olfactory Receptor OR1-1 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 16 2
  • Olfactory Receptor 4F3/4F16/4F29 3
  • Olfactory Receptor OR4F16 3
  • Olfactory Receptor OR7-21 3
  • OR7-21 3
  • OR1-1 3

External Ids for OR4F16 Gene

Previous GeneCards Identifiers for OR4F16 Gene

  • GC06U990266
  • GC08M000108
  • GC01M000662
  • GC01M000611
  • GC05P180727
  • GC01M000622

Summaries for OR4F16 Gene

Entrez Gene Summary for OR4F16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F16 Gene

OR4F16 (Olfactory Receptor Family 4 Subfamily F Member 16) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F3.

UniProtKB/Swiss-Prot for OR4F16 Gene

  • Odorant receptor.

Gene Wiki entry for OR4F16 Gene

Additional gene information for OR4F16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4F16 Gene

Genomics for OR4F16 Gene

GeneHancer (GH) Regulatory Elements for OR4F16 Gene

Top Transcription factor binding sites by QIAGEN in the OR4F16 gene promoter:
  • E4BP4
  • POU3F1
  • HTF
  • SRF (504 AA)
  • SRF
  • Pax-4a
  • FOXL1
  • Meis-1b
  • Meis-1
  • HOXA9B

Genomic Locations for OR4F16 Gene

Genomic Locations for OR4F16 Gene
995 bases
Minus strand
995 bases
Minus strand

Genomic View for OR4F16 Gene

Genes around OR4F16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F16 Gene

Proteins for OR4F16 Gene

  • Protein details for OR4F16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4F3/4F16/4F29
    Protein Accession:
    Secondary Accessions:
    • B2RPQ6
    • B2RPQ6
    • B2RPQ6

    Protein attributes for OR4F16 Gene

    312 amino acids
    Molecular mass:
    35074 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F16 Gene

Post-translational modifications for OR4F16 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4F16 Gene

No data available for DME Specific Peptides for OR4F16 Gene

Domains & Families for OR4F16 Gene

Gene Families for OR4F16 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F16: view

No data available for Suggested Antigen Peptide Sequences for OR4F16 Gene

Function for OR4F16 Gene

Molecular function for OR4F16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F16: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F16 Gene

Localization for OR4F16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4F16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F16 Gene

Pathways & Interactions for OR4F16 Gene

genes like me logo Genes that share pathways with OR4F16: view

Pathways by source for OR4F16 Gene

Interacting Proteins for OR4F16 Gene

Gene Ontology (GO) - Biological Process for OR4F16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4F16: view

No data available for SIGNOR curated interactions for OR4F16 Gene

Drugs & Compounds for OR4F16 Gene

No Compound Related Data Available

Transcripts for OR4F16 Gene

mRNA/cDNA for OR4F16 Gene

(8) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4F16 Gene

Olfactory receptor, family 4, subfamily F, member 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F16 Gene

No ASD Table

Relevant External Links for OR4F16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4F16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4F16 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4F16 Gene:


SOURCE GeneReport for Unigene cluster for OR4F16 Gene:

genes like me logo Genes that share expression patterns with OR4F16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F16 Gene

Orthologs for OR4F16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC744286 33
  • 99.14 (n)
(Rattus norvegicus)
Mammalia Olr774 33
  • 82.48 (n)
(Mus musculus)
Mammalia Olfr1303 33
  • 82.37 (n)
(Canis familiaris)
Mammalia cOR4F25 33
  • 78.1 (n)
(Bos Taurus)
Mammalia LOC788764 33
  • 77.16 (n)
Species where no ortholog for OR4F16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4F16 Gene

Gene Tree for OR4F16 (if available)
Gene Tree for OR4F16 (if available)

Paralogs for OR4F16 Gene

Paralogs for OR4F16 Gene

(435) SIMAP similar genes for OR4F16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4F16: view

Variants for OR4F16 Gene

Sequence variations from dbSNP and Humsavar for OR4F16 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001626281 -- 719,635(-) G/C genic_upstream_transcript_variant, intron_variant
rs1001951745 -- 712,029(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002089161 -- 713,460(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1003628013 -- 701,757(-) T/A genic_upstream_transcript_variant, intron_variant
rs1003763690 -- 702,169(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4F16 Gene

Variant ID Type Subtype PubMed ID
dgv1e24 CNV loss 17666407
dgv1n14 CNV gain 18776910
dgv2n14 CNV gain 18776910
dgv5n100 CNV gain 25217958
esv21732 CNV gain+loss 19812545
esv27883 CNV gain+loss 19812545
esv28275 CNV gain+loss 19812545
nsv1003571 CNV loss 25217958
nsv1004962 CNV gain 25217958
nsv10793 CNV gain+loss 18304495
nsv1126162 CNV deletion 24896259
nsv1126737 CNV deletion 24896259
nsv1143424 CNV deletion 24896259
nsv428223 CNV gain+loss 18775914
nsv471442 CNV gain 19718026
nsv471518 CNV gain 19718026
nsv471522 CNV gain 19718026
nsv482937 CNV loss 15286789
nsv514924 CNV gain 21397061
nsv820415 CNV deletion 20802225
nsv829647 CNV gain+loss 17160897
nsv830758 CNV loss 17160897
nsv831869 CNV gain+loss 17160897
nsv945265 OTHER complex 23825009
nsv945736 OTHER complex 23825009
nsv964808 OTHER complex 23825009

Additional Variant Information for OR4F16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OR4F16 Gene

Disorders for OR4F16 Gene

Additional Disease Information for OR4F16

No disorders were found for OR4F16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F16 Gene

Publications for OR4F16 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4F16 Gene

Sources for OR4F16 Gene

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