Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4F15 Gene

Aliases for OR4F15 Gene

  • Olfactory Receptor Family 4 Subfamily F Member 15 2 3 5
  • Olfactory Receptor OR15-14 3 4
  • Olfactory Receptor 4F15 3 4
  • Olfactory Receptor, Family 4, Subfamily F, Member 15 2
  • OR4F15 5

External Ids for OR4F15 Gene

Previous GeneCards Identifiers for OR4F15 Gene

  • GC06U990267
  • GC15P100096
  • GC15P100175
  • GC15P102358
  • GC15P101806
  • GC15P101993
  • GC15P104703
  • GC15P104769
  • GC15P104813
  • GC15P105639
  • GC15P102171
  • GC15P102779
  • GC15P102970
  • GC15P103629
  • GC15P104116
  • GC15P104307
  • GC15P104484
  • GC15P104637
  • GC15P106100
  • GC15P106561

Summaries for OR4F15 Gene

Entrez Gene Summary for OR4F15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4F15 Gene

OR4F15 (Olfactory Receptor Family 4 Subfamily F Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4F21.

UniProtKB/Swiss-Prot Summary for OR4F15 Gene

Gene Wiki entry for OR4F15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4F15 Gene

Genomics for OR4F15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4F15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J101813 Enhancer 0.5 ENCODE 250.7 +2.0 1974 1.7 ZNF316 NFE2 NFE2L2 MAFK MAFG FOS CEBPB OR4F15 LOC100128108 WASH3P TARS3 lnc-OR4F15-5 OR4F14P OR4F4
GH15J101662 Enhancer 0.4 FANTOM5 1.5 -149.9 -149917 0.3 PRDM6 SP7 ZNF558 TM2D3 OR4F15 HSALNG0108656 lnc-OR4F6-6 TARS3
GH15J101807 Enhancer 0.6 Ensembl ENCODE 0.7 -4.2 -4182 1.8 REST MAFK NFE2L2 FOS CEBPB ZSCAN5C lnc-OR4F15-5 LOC100128108 WASH3P OR4F15 OR4F6
GH15J101405 Enhancer 0.2 FANTOM5 2 -406.5 -406504 0 PCSK6 OR4F6 OR4F15 MK280607-005 RF00017-1705 SNRPA1 LOC100507472
GH15J101397 Enhancer 0.2 FANTOM5 1.8 -414.7 -414661 0.1 RNU6-807P PCSK6 OR4F6 OR4F15 TM2D3 RF00017-1705 lnc-SNRPA1-2 SNRPA1 LOC100507472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4F15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4F15

Top Transcription factor binding sites by QIAGEN in the OR4F15 gene promoter:
  • AML1a
  • En-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • LCR-F1
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for OR4F15 Gene

Latest Assembly
chr15:101,812,202-101,820,197
(GRCh38/hg38)
Size:
7,996 bases
Orientation:
Plus strand

Previous Assembly
chr15:102,352,405-102,360,400
(GRCh37/hg19 by Entrez Gene)
Size:
7,996 bases
Orientation:
Plus strand

chr15:102,358,366-102,359,350
(GRCh37/hg19 by Ensembl)
Size:
985 bases
Orientation:
Plus strand

Genomic View for OR4F15 Gene

Genes around OR4F15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4F15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4F15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4F15 Gene

Proteins for OR4F15 Gene

  • Protein details for OR4F15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB8-O4F15_HUMAN
    Recommended name:
    Olfactory receptor 4F15
    Protein Accession:
    Q8NGB8
    Secondary Accessions:
    • B2RNQ5
    • Q6IF57
    • Q96R70

    Protein attributes for OR4F15 Gene

    Size:
    312 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4F15 Gene

Post-translational modifications for OR4F15 Gene

  • Glycosylation at Asn5

Other Protein References for OR4F15 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4F15 Gene

Domains & Families for OR4F15 Gene

Gene Families for OR4F15 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4F15 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4F15 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR15-14 (O4F15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGB8

UniProtKB/Swiss-Prot:

O4F15_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4F15: view

Function for OR4F15 Gene

Molecular function for OR4F15 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4F15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4F15: view
genes like me logo Genes that share phenotypes with OR4F15: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F15

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4F15 Gene

Localization for OR4F15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4F15 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4F15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4F15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4F15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4F15 Gene

Pathways & Interactions for OR4F15 Gene

genes like me logo Genes that share pathways with OR4F15: view

Pathways by source for OR4F15 Gene

Interacting Proteins for OR4F15 Gene

Gene Ontology (GO) - Biological Process for OR4F15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4F15: view

No data available for SIGNOR curated interactions for OR4F15 Gene

Drugs & Compounds for OR4F15 Gene

No Compound Related Data Available

Transcripts for OR4F15 Gene

mRNA/cDNA for OR4F15 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4F15

Alternative Splicing Database (ASD) splice patterns (SP) for OR4F15 Gene

No ASD Table

Relevant External Links for OR4F15 Gene

GeneLoc Exon Structure for
OR4F15

Expression for OR4F15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4F15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4F15

SOURCE GeneReport for Unigene cluster for OR4F15 Gene:

Hs.554589
genes like me logo Genes that share expression patterns with OR4F15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4F15 Gene

Orthologs for OR4F15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4F15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC467783 29
  • 99.47 (n)
OR4F15 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR4F15 29 30
  • 88.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr782 29
  • 84.14 (n)
Mouse
(Mus musculus)
Mammalia Or4f15 45 Olfr1309 29 16 30
  • 84.14 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 68 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 66 (a)
ManyToMany
Species where no ortholog for OR4F15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4F15 Gene

ENSEMBL:
Gene Tree for OR4F15 (if available)
TreeFam:
Gene Tree for OR4F15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4F15: view image
Alliance of Genome Resources:
Additional Orthologs for OR4F15

Paralogs for OR4F15 Gene

(435) SIMAP similar genes for OR4F15 Gene using alignment to 1 proteins:

  • O4F15_HUMAN

Pseudogenes.org Pseudogenes for OR4F15 Gene

genes like me logo Genes that share paralogs with OR4F15: view

Variants for OR4F15 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4F15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4F15 Gene

Variant ID Type Subtype PubMed ID
dgv113e55 CNV gain 17911159
dgv2677n100 CNV loss 25217958
dgv2684n100 CNV gain 25217958
dgv2685n100 CNV gain 25217958
dgv2686n100 CNV gain 25217958
dgv470e214 CNV gain 21293372
dgv4801n54 CNV gain 21841781
dgv4802n54 CNV gain 21841781
dgv766e212 CNV gain 25503493
dgv768e212 CNV gain 25503493
esv2751291 CNV gain 17911159
esv2760064 CNV gain 17122850
esv2760373 CNV gain 21179565
esv2761688 CNV gain+loss 21179565
esv3581886 CNV loss 25503493
esv3637524 CNV loss 21293372
esv3637525 CNV gain 21293372
esv3637528 CNV loss 21293372
nsv1036552 CNV gain 25217958
nsv1040586 CNV gain 25217958
nsv1041586 CNV gain 25217958
nsv1052710 CNV gain 25217958
nsv1054517 CNV loss 25217958
nsv469527 CNV loss 16826518
nsv469708 CNV gain 16826518
nsv519940 CNV gain 19592680
nsv524612 CNV loss 19592680
nsv570915 CNV loss 21841781
nsv570916 CNV gain 21841781
nsv570917 CNV loss 21841781
nsv9314 CNV gain+loss 18304495

Variation tolerance for OR4F15 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4F15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4F15
Leiden Open Variation Database (LOVD)
OR4F15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4F15 Gene

Disorders for OR4F15 Gene

Additional Disease Information for OR4F15

No disorders were found for OR4F15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4F15 Gene

Publications for OR4F15 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y … Pääbo S (American journal of human genetics 2003) 3

Products for OR4F15 Gene

Sources for OR4F15 Gene