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Aliases for OR4E2 Gene

Aliases for OR4E2 Gene

  • Olfactory Receptor Family 4 Subfamily E Member 2 2 3 5
  • Olfactory Receptor OR14-42 3 4
  • Olfactory Receptor, Family 4, Subfamily E, Member 2 2
  • Olfactory Receptor 4E2 3
  • OR14-42 3

External Ids for OR4E2 Gene

Previous GeneCards Identifiers for OR4E2 Gene

  • GC14U990090
  • GC14P021203
  • GC14P022133

Summaries for OR4E2 Gene

Entrez Gene Summary for OR4E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4E2 Gene

OR4E2 (Olfactory Receptor Family 4 Subfamily E Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4E1.

UniProtKB/Swiss-Prot for OR4E2 Gene

  • Odorant receptor.

Gene Wiki entry for OR4E2 Gene

Additional gene information for OR4E2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4E2 Gene

Genomics for OR4E2 Gene

GeneHancer (GH) Regulatory Elements for OR4E2 Gene

Promoters and enhancers for OR4E2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021999 Enhancer 0.2 FANTOM5 7.9 +345.7 345748 0.1 OR10G3 OR4E2 OR10G2 TRAV17 TRAV18 TRA
GH14J021992 Enhancer 0.4 FANTOM5 2.5 +339.1 339062 0.1 CREB1 OR10G3 OR4E2 TRAV16 TRAV17 TRA
GH14J021216 Enhancer 0.3 FANTOM5 1.9 -437.0 -437045 0.3 TRAV8-5 OR10G2 OR5AU1 RNASE8 OR4E2 OR10G3 GC14P021210 GC14P021211 GC14P021259 HNRNPC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4E2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4E2 gene promoter:
  • E2F-1
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • AREB6
  • E2F
  • HFH-1
  • ATF6
  • CUTL1

Genomic Locations for OR4E2 Gene

Genomic Locations for OR4E2 Gene
13,808 bases
Plus strand
942 bases
Plus strand

Genomic View for OR4E2 Gene

Genes around OR4E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4E2 Gene

Proteins for OR4E2 Gene

  • Protein details for OR4E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4E2
    Protein Accession:
    Secondary Accessions:
    • Q6IET6
    • Q96R62

    Protein attributes for OR4E2 Gene

    313 amino acids
    Molecular mass:
    35466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4E2 Gene

Post-translational modifications for OR4E2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4E2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4E2 Gene

Domains & Families for OR4E2 Gene

Gene Families for OR4E2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4E2 Gene

Suggested Antigen Peptide Sequences for OR4E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4E2: view

Function for OR4E2 Gene

Molecular function for OR4E2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4E2: view
genes like me logo Genes that share phenotypes with OR4E2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4E2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4E2 Gene

Localization for OR4E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4E2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4E2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4E2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4E2 Gene

Pathways & Interactions for OR4E2 Gene

genes like me logo Genes that share pathways with OR4E2: view

Pathways by source for OR4E2 Gene

Interacting Proteins for OR4E2 Gene

Gene Ontology (GO) - Biological Process for OR4E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4E2: view

No data available for SIGNOR curated interactions for OR4E2 Gene

Drugs & Compounds for OR4E2 Gene

No Compound Related Data Available

Transcripts for OR4E2 Gene

mRNA/cDNA for OR4E2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4E2 Gene

Olfactory receptor, family 4, subfamily E, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4E2

Alternative Splicing Database (ASD) splice patterns (SP) for OR4E2 Gene

No ASD Table

Relevant External Links for OR4E2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4E2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4E2 Gene:


SOURCE GeneReport for Unigene cluster for OR4E2 Gene:

genes like me logo Genes that share expression patterns with OR4E2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4E2 Gene

Orthologs for OR4E2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4E2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC467386 33
  • 99.04 (n)
OR4E2 34
  • 98 (a)
(Bos Taurus)
Mammalia OR4E2 34 33
  • 89.03 (n)
(Rattus norvegicus)
Mammalia Olr1643 33
  • 86.27 (n)
(Mus musculus)
Mammalia Or4e2 51 Olfr1509 16 34 33
  • 86.17 (n)
(Canis familiaris)
Mammalia OR4E2 34
  • 83 (a)
(Monodelphis domestica)
Mammalia OR4E2 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia OR4E2 34
  • 67 (a)
(Anolis carolinensis)
Reptilia OR4E2 34
  • 59 (a)
Species where no ortholog for OR4E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4E2 Gene

Gene Tree for OR4E2 (if available)
Gene Tree for OR4E2 (if available)
Evolutionary constrained regions (ECRs) for OR4E2: view image

Paralogs for OR4E2 Gene

Paralogs for OR4E2 Gene

(447) SIMAP similar genes for OR4E2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4E2: view

Variants for OR4E2 Gene

Sequence variations from dbSNP and Humsavar for OR4E2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001591815 -- 21,666,205(+) T/A downstream_transcript_variant
rs1002910603 -- 21,663,820(+) T/C upstream_transcript_variant
rs1004318431 -- 21,664,403(+) G/A upstream_transcript_variant
rs1004409338 -- 21,664,275(+) G/A upstream_transcript_variant
rs1005360969 -- 21,665,374(+) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4E2 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639
nsv456147 CNV gain 19166990
nsv563851 CNV gain 21841781

Variation tolerance for OR4E2 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4E2 Gene

Disorders for OR4E2 Gene

Additional Disease Information for OR4E2

No disorders were found for OR4E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4E2 Gene

Publications for OR4E2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (PMID: 9110172) Boysen C … Hood L (Genome research 1997) 3 58
  4. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4E2 Gene

Sources for OR4E2 Gene

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