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Aliases for OR4D9 Gene

Aliases for OR4D9 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 9 2 3 5
  • Olfactory Receptor, Family 4, Subfamily D, Member 9 Pseudogene 2 3
  • Olfactory Receptor OR11-253 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 9 2
  • Olfactory Receptor 4D9 3
  • OR11-253 3

External Ids for OR4D9 Gene

Previous GeneCards Identifiers for OR4D9 Gene

  • GC11U990535
  • GC11P059058
  • GC11P059038
  • GC11P059282

Summaries for OR4D9 Gene

Entrez Gene Summary for OR4D9 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D9 Gene

OR4D9 (Olfactory Receptor Family 4 Subfamily D Member 9) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot for OR4D9 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D9 Gene

Additional gene information for OR4D9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D9 Gene

Genomics for OR4D9 Gene

GeneHancer (GH) Regulatory Elements for OR4D9 Gene

Promoters and enhancers for OR4D9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I059510 Enhancer 1 FANTOM5 Ensembl ENCODE 550.8 -0.3 -267 1 ETV1 CEBPB MAFG CEBPG ATF4 STAT2 NFE2 EMSY OR4D9 OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D11
GH11I059544 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +37.7 37740 8.8 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GC11M059554 TRV-TAC1-1 TRV-TAC2-1 GC11P059550 ENSG00000269570 LOC101927226 PATL1 ENSG00000255008 FAM111A-DT STX3
GH11I059536 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.6 +26.2 26236 1.8 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT SIN3A YY1 TCF12 ZNF121 LOC102723575 OR4D9 LOC101927226 OR4D10 OR5A2 OR4D6 PATL1 OR5AN1 STX3 GC11P059550
GH11I059266 Enhancer 0.4 FANTOM5 dbSUPER 2.1 -244.7 -244688 0.1 OR4D10 OR4D9 OR4D6 OR10V1 OR5A1 GC11M059264 ENSG00000214797 SLC25A47P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR4D9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4D9 gene promoter:

Genomic Locations for OR4D9 Gene

Genomic Locations for OR4D9 Gene
chr11:59,511,368-59,520,703
(GRCh38/hg38)
Size:
9,336 bases
Orientation:
Plus strand
chr11:59,282,386-59,283,330
(GRCh37/hg19)

Genomic View for OR4D9 Gene

Genes around OR4D9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D9 Gene

Proteins for OR4D9 Gene

  • Protein details for OR4D9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE8-OR4D9_HUMAN
    Recommended name:
    Olfactory receptor 4D9
    Protein Accession:
    Q8NGE8
    Secondary Accessions:
    • Q6IFF3

    Protein attributes for OR4D9 Gene

    Size:
    314 amino acids
    Molecular mass:
    35666 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D9 Gene

Post-translational modifications for OR4D9 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D9 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D9 Gene

Domains & Families for OR4D9 Gene

Gene Families for OR4D9 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D9 Gene

Suggested Antigen Peptide Sequences for OR4D9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGE8

UniProtKB/Swiss-Prot:

OR4D9_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D9: view

Function for OR4D9 Gene

Molecular function for OR4D9 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4D9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D9: view
genes like me logo Genes that share phenotypes with OR4D9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D9 Gene

Localization for OR4D9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4D9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D9 Gene

Pathways & Interactions for OR4D9 Gene

genes like me logo Genes that share pathways with OR4D9: view

Pathways by source for OR4D9 Gene

Interacting Proteins for OR4D9 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328563%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000312262%0d%0a9606.ENSP00000359719%0d%0a
Selected Interacting proteins: Q8NGE8-OR4D9_HUMAN ENSP00000328563 for OR4D9 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR4D9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4D9: view

No data available for SIGNOR curated interactions for OR4D9 Gene

Drugs & Compounds for OR4D9 Gene

No Compound Related Data Available

Transcripts for OR4D9 Gene

mRNA/cDNA for OR4D9 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D9 Gene

No ASD Table

Relevant External Links for OR4D9 Gene

GeneLoc Exon Structure for
OR4D9
ECgene alternative splicing isoforms for
OR4D9

Expression for OR4D9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4D9 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4D9 Gene:

OR4D9

SOURCE GeneReport for Unigene cluster for OR4D9 Gene:

Hs.553757
genes like me logo Genes that share expression patterns with OR4D9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D9 Gene

Orthologs for OR4D9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466616 33
  • 98.73 (n)
OR4D9 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR4D9 33 34
  • 87.57 (n)
cow
(Bos Taurus)
Mammalia OR4D9 33 34
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Olr322 33
  • 80.41 (n)
mouse
(Mus musculus)
Mammalia Olfr1425 33 16
  • 79.33 (n)
Olfr1427 34
  • 77 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
ManyToMany
-- 34
  • 78 (a)
ManyToMany
-- 34
  • 77 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
Species where no ortholog for OR4D9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D9 Gene

ENSEMBL:
Gene Tree for OR4D9 (if available)
TreeFam:
Gene Tree for OR4D9 (if available)

Paralogs for OR4D9 Gene

(441) SIMAP similar genes for OR4D9 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR4D9 Gene

genes like me logo Genes that share paralogs with OR4D9: view

Variants for OR4D9 Gene

Sequence variations from dbSNP and Humsavar for OR4D9 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1003175355 -- 59,515,797(+) G/T coding_sequence_variant, missense_variant
rs1006410596 -- 59,513,876(+) T/A upstream_transcript_variant
rs1006973182 -- 59,514,790(+) T/G upstream_transcript_variant
rs1007337813 -- 59,513,829(+) G/A upstream_transcript_variant
rs1007717425 -- 59,513,599(+) T/C upstream_transcript_variant

Variation tolerance for OR4D9 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4D9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR4D9 Gene

Disorders for OR4D9 Gene

Additional Disease Information for OR4D9

No disorders were found for OR4D9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D9 Gene

Publications for OR4D9 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for OR4D9 Gene

Sources for OR4D9 Gene

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