Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR4D6 Gene

Aliases for OR4D6 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 6 2 3 5
  • Olfactory Receptor OR11-250 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 6 2
  • Olfactory Receptor 4D6 3
  • OR11-250 3

External Ids for OR4D6 Gene

Previous GeneCards Identifiers for OR4D6 Gene

  • GC11U990538
  • GC11P059000
  • GC11P058981
  • GC11P059224

Summaries for OR4D6 Gene

Entrez Gene Summary for OR4D6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D6 Gene

OR4D6 (Olfactory Receptor Family 4 Subfamily D Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot for OR4D6 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D6 Gene

Additional gene information for OR4D6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D6 Gene

Genomics for OR4D6 Gene

GeneHancer (GH) Regulatory Elements for OR4D6 Gene

Promoters and enhancers for OR4D6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I059456 Promoter 0.5 EPDnew 550.8 +0.1 54 0.1 OR4D6 GC11P059465
GH11I059544 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +92.2 92170 8.8 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GC11M059554 GC11P059550 TRV-TAC1-1 TRV-TAC2-1 ENSG00000269570 LOC101927226 PATL1 ENSG00000255008 FAM111A-DT STX3
GH11I059220 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -233.9 -233907 5.1 CTCF JUN CEBPG BATF RFX5 SMC3 FOS IKZF2 RUNX3 CEBPB PATL1 MPEG1 DTX4 OR4D6 OR5A2 OR5A1 OR5AN1 FAM111A OSBP RN7SL42P
GH11I059536 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.1 +80.7 80666 1.8 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT SIN3A YY1 TCF12 ZNF121 LOC102723575 OR4D9 LOC101927226 OR4D10 OR5A2 OR4D6 PATL1 OR5AN1 STX3 GC11P059550
GH11I059510 Enhancer 1 FANTOM5 Ensembl ENCODE 13.6 +54.2 54163 1 ETV1 CEBPB MAFG CEBPG ATF4 STAT2 NFE2 EMSY OR4D9 OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR4D6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4D6 gene promoter:

Genomic Locations for OR4D6 Gene

Genomic Locations for OR4D6 Gene
1,054 bases
Plus strand

Genomic View for OR4D6 Gene

Genes around OR4D6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D6 Gene

Proteins for OR4D6 Gene

  • Protein details for OR4D6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4D6
    Protein Accession:
    Secondary Accessions:
    • B2RNP7
    • Q6IFF5
    • Q96R74

    Protein attributes for OR4D6 Gene

    314 amino acids
    Molecular mass:
    35954 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D6 Gene

Post-translational modifications for OR4D6 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D6 Gene

Domains & Families for OR4D6 Gene

Gene Families for OR4D6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D6 Gene

Suggested Antigen Peptide Sequences for OR4D6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D6: view

Function for OR4D6 Gene

Molecular function for OR4D6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4D6 Gene

Gene Ontology (GO) - Molecular Function for OR4D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D6: view

Phenotypes for OR4D6 Gene

GenomeRNAi human phenotypes for OR4D6:
genes like me logo Genes that share phenotypes with OR4D6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D6 Gene

Localization for OR4D6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4D6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D6 Gene

Pathways & Interactions for OR4D6 Gene

genes like me logo Genes that share pathways with OR4D6: view

Pathways by source for OR4D6 Gene

Gene Ontology (GO) - Biological Process for OR4D6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4D6: view

No data available for SIGNOR curated interactions for OR4D6 Gene

Drugs & Compounds for OR4D6 Gene

No Compound Related Data Available

Transcripts for OR4D6 Gene

mRNA/cDNA for OR4D6 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D6 Gene

No ASD Table

Relevant External Links for OR4D6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4D6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4D6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4D6 Gene:


SOURCE GeneReport for Unigene cluster for OR4D6 Gene:

genes like me logo Genes that share expression patterns with OR4D6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D6 Gene

Orthologs for OR4D6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466613 33
  • 98.62 (n)
OR4D6 34
  • 96 (a)
(Canis familiaris)
Mammalia OR4D6 34
  • 88 (a)
LOC100856774 33
  • 87.96 (n)
(Bos Taurus)
Mammalia OR4D6 33 34
  • 85.26 (n)
(Rattus norvegicus)
Mammalia Olr325 33
  • 84.82 (n)
(Mus musculus)
Mammalia Or4d6 51 Olfr1428 33 16 34
  • 83.97 (n)
(Monodelphis domestica)
Mammalia OR4D6 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
-- 34
  • 64 (a)
-- 34
  • 61 (a)
-- 34
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
-- 34
  • 47 (a)
Species where no ortholog for OR4D6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D6 Gene

Gene Tree for OR4D6 (if available)
Gene Tree for OR4D6 (if available)

Paralogs for OR4D6 Gene

(435) SIMAP similar genes for OR4D6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D6: view

Variants for OR4D6 Gene

Sequence variations from dbSNP and Humsavar for OR4D6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1004032909 -- 59,457,603(+) C/T coding_sequence_variant, synonymous_variant
rs1004063967 -- 59,457,371(+) G/A coding_sequence_variant, synonymous_variant
rs1004641663 -- 59,455,295(+) TTTTTTTTT/TTTTTTTTTT upstream_transcript_variant
rs1005697695 -- 59,456,220(+) A/C upstream_transcript_variant
rs1006637199 -- 59,455,236(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4D6 Gene

Variant ID Type Subtype PubMed ID
nsv825934 CNV loss 20364138

Variation tolerance for OR4D6 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.17; 96.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4D6 Gene

Disorders for OR4D6 Gene

Additional Disease Information for OR4D6

No disorders were found for OR4D6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D6 Gene

Publications for OR4D6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Identification of regions associated with variation in sensitivity to food-related odors in the human genome. (PMID: 23910658) McRae JF … Newcomb RD (Current biology : CB 2013) 3 58
  4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for OR4D6 Gene

Sources for OR4D6 Gene

Loading form....