Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4D5 Gene

Aliases for OR4D5 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 5 2 3 5
  • Olfactory Receptor OR11-276 3 4
  • Olfactory Receptor 4D5 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 5 2
  • OR11-276 3
  • OR4D5 5

External Ids for OR4D5 Gene

Previous GeneCards Identifiers for OR4D5 Gene

  • GC11U990334
  • GC11P123348
  • GC11P123316
  • GC11P123810

Summaries for OR4D5 Gene

Entrez Gene Summary for OR4D5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D5 Gene

OR4D5 (Olfactory Receptor Family 4 Subfamily D Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D9.

UniProtKB/Swiss-Prot Summary for OR4D5 Gene

Gene Wiki entry for OR4D5 Gene

Additional gene information for OR4D5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4D5 Gene

Genomics for OR4D5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4D5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 6.6 -197.7 -197747 4.4 PRDM10 TFE3 ZNF512 LEF1 POLR2A ZNF7 BACH1 JUND GABPA MTA2 ZNF202 lnc-GRAMD1B-6 lnc-ZNF202-1 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J124008 Enhancer 0.2 FANTOM5 18.3 +69.1 69131 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1
GH11J123695 Enhancer 0.2 FANTOM5 13.5 -244.2 -244209 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11J123962 Enhancer 0.2 Ensembl 11.2 +22.6 22558 0.2 OR4D5 OR8D4 piR-57965-012 OR10S1 OR6T1
GH11J123961 Enhancer 0.2 Ensembl 11.2 +22.2 22158 0.2 OR4D5 OR8D4 piR-57965-012 OR10S1 OR6T1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4D5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4D5

Top Transcription factor binding sites by QIAGEN in the OR4D5 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • POU2F1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR4D5 Gene

Genomic Locations for OR4D5 Gene
chr11:123,939,543-123,940,637
(GRCh38/hg38)
Size:
1,095 bases
Orientation:
Plus strand
chr11:123,810,250-123,811,344
(GRCh37/hg19)
Size:
1,095 bases
Orientation:
Plus strand

Genomic View for OR4D5 Gene

Genes around OR4D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D5 Gene

Proteins for OR4D5 Gene

  • Protein details for OR4D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN0-OR4D5_HUMAN
    Recommended name:
    Olfactory receptor 4D5
    Protein Accession:
    Q8NGN0
    Secondary Accessions:
    • B9EGZ4
    • Q6IFE6

    Protein attributes for OR4D5 Gene

    Size:
    318 amino acids
    Molecular mass:
    35771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D5 Gene

Post-translational modifications for OR4D5 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D5 Gene

Domains & Families for OR4D5 Gene

Gene Families for OR4D5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR4D5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-276 (OR4D5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGN0

UniProtKB/Swiss-Prot:

OR4D5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D5: view

Function for OR4D5 Gene

Molecular function for OR4D5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4D5 Gene

Gene Ontology (GO) - Molecular Function for OR4D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D5: view
genes like me logo Genes that share phenotypes with OR4D5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4D5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D5 Gene

Localization for OR4D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4D5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D5 Gene

Pathways & Interactions for OR4D5 Gene

genes like me logo Genes that share pathways with OR4D5: view

Pathways by source for OR4D5 Gene

Interacting Proteins for OR4D5 Gene

Gene Ontology (GO) - Biological Process for OR4D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4D5: view

No data available for SIGNOR curated interactions for OR4D5 Gene

Drugs & Compounds for OR4D5 Gene

No Compound Related Data Available

Transcripts for OR4D5 Gene

mRNA/cDNA for OR4D5 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4D5

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D5 Gene

No ASD Table

Relevant External Links for OR4D5 Gene

GeneLoc Exon Structure for
OR4D5

Expression for OR4D5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4D5 Gene

mRNA differential expression in normal tissues according to GTEx for OR4D5 Gene

This gene is overexpressed in Pancreas (x34.6) and Testis (x7.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4D5

SOURCE GeneReport for Unigene cluster for OR4D5 Gene:

Hs.553639
genes like me logo Genes that share expression patterns with OR4D5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D5 Gene

Orthologs for OR4D5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4D5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466816 30
  • 99.58 (n)
Dog
(Canis familiaris)
Mammalia OR4D5 30 31
  • 89.92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR4D5 30 31
  • 88.11 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR4D5 31
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1339 30
  • 86.73 (n)
Mouse
(Mus musculus)
Mammalia Or4d5 46 Olfr984 30 17 31
  • 85.88 (n)
OneToOne
Species where no ortholog for OR4D5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4D5 Gene

ENSEMBL:
Gene Tree for OR4D5 (if available)
TreeFam:
Gene Tree for OR4D5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4D5: view image

Paralogs for OR4D5 Gene

(433) SIMAP similar genes for OR4D5 Gene using alignment to 1 proteins:

  • OR4D5_HUMAN
genes like me logo Genes that share paralogs with OR4D5: view

Variants for OR4D5 Gene

Additional dbSNP identifiers (rs#s) for OR4D5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR4D5 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680

Variation tolerance for OR4D5 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4D5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4D5 Gene

Disorders for OR4D5 Gene

No disorders were found for OR4D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D5 Gene

Publications for OR4D5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR4D5 Gene

Sources for OR4D5 Gene