Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4D2 Gene

Aliases for OR4D2 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 2 2 3 5
  • B-Lymphocyte Membrane Protein BC2009 3 4
  • Olfactory Receptor OR17-24 3 4
  • Olfactory Receptor 4D2 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 2 2
  • G-Protein Coupled Membrane Protein 3
  • OR17-24 3
  • BC2009 3

External Ids for OR4D2 Gene

Previous GeneCards Identifiers for OR4D2 Gene

  • GC17U990167
  • GC17P056722
  • GC17P053601
  • GC17P056246
  • GC17P056248
  • GC17P056253

Summaries for OR4D2 Gene

Entrez Gene Summary for OR4D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D2 Gene

OR4D2 (Olfactory Receptor Family 4 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D1.

UniProtKB/Swiss-Prot Summary for OR4D2 Gene

Gene Wiki entry for OR4D2 Gene

Additional gene information for OR4D2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4D2 Gene

Genomics for OR4D2 Gene

GeneHancer (GH) Regulatory Elements for OR4D2 Gene

Promoters and enhancers for OR4D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058136 Enhancer 0.6 ENCODE 11.9 -30.1 -30117 0.1 CTCF TCF7L2 RAD21 ZNF652 PKNOX1 ZNF512B SMC3 ZNF207 XRCC5 MTA2 OR4D2 MKS1 EPX SRSF1 LPO piR-43583-232 piR-40110-283
GH17J057897 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.2 -265.1 -265114 8.1 PPP1R10 E2F8 SP1 SREBF1 FOXA1 MLX RBPJ TCF7L2 ZNF217 MIXL1 SRSF1 MKS1 CUEDC1 COIL ENSG00000262298 ENSG00000264112 EPX VEZF1 ENSG00000263004 OR4D2
GH17J058328 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.4 +170.5 170535 21 ZNF24 SP1 ZBTB40 SMARCE1 HDAC2 HCFC1 TRIM22 RUNX1 MYC CC2D1A TSPOAP1 MIR4736 SRSF1 MKS1 VEZF1 SMG8 SUPT4H1 ENSG00000264112 TRIM37 ENSG00000224738
GH17J058522 Enhancer 0.5 FANTOM5 dbSUPER 4.3 +355.7 355739 0.1 NBN OR4D2 DYNLL2 SEPTIN4-AS1 lnc-C17orf47-1 ENSG00000108387 SEPTIN4
GH17J058169 Enhancer 0.8 Ensembl ENCODE 0.6 +3.6 3619 4.4 E2F8 CTCF RAD21 RXRA REST HES1 SMARCA5 SMC3 PRDM4 CUX1 MKS1 SRSF1 EPX TSPOAP1 OR4D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4D2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4D2 gene promoter:
  • AP-1
  • GATA-1
  • NRSF form 1
  • NRSF form 2
  • Olf-1
  • p53
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR4D2 Gene

Genomic Locations for OR4D2 Gene
chr17:58,166,982-58,171,411
(GRCh38/hg38)
Size:
4,430 bases
Orientation:
Plus strand
chr17:56,247,017-56,247,940
(GRCh37/hg19)
Size:
924 bases
Orientation:
Plus strand

Genomic View for OR4D2 Gene

Genes around OR4D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D2 Gene

Proteins for OR4D2 Gene

  • Protein details for OR4D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58180-OR4D2_HUMAN
    Recommended name:
    Olfactory receptor 4D2
    Protein Accession:
    P58180
    Secondary Accessions:
    • Q6IFN8
    • Q96R75

    Protein attributes for OR4D2 Gene

    Size:
    307 amino acids
    Molecular mass:
    34958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D2 Gene

Post-translational modifications for OR4D2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D2 Gene

Domains & Families for OR4D2 Gene

Gene Families for OR4D2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D2 Gene

Suggested Antigen Peptide Sequences for OR4D2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR17-24 (OR4D2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P58180

UniProtKB/Swiss-Prot:

OR4D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D2: view

Function for OR4D2 Gene

Molecular function for OR4D2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 4,subfamily D,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR4D2 Gene

Gene Ontology (GO) - Molecular Function for OR4D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D2: view
genes like me logo Genes that share phenotypes with OR4D2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D2 Gene

Localization for OR4D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4D2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D2 Gene

Pathways & Interactions for OR4D2 Gene

genes like me logo Genes that share pathways with OR4D2: view

Pathways by source for OR4D2 Gene

Interacting Proteins for OR4D2 Gene

Gene Ontology (GO) - Biological Process for OR4D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4D2: view

No data available for SIGNOR curated interactions for OR4D2 Gene

Drugs & Compounds for OR4D2 Gene

(3) Drugs for OR4D2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for OR4D2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OR4D2: view

Transcripts for OR4D2 Gene

mRNA/cDNA for OR4D2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D2 Gene

No ASD Table

Relevant External Links for OR4D2 Gene

GeneLoc Exon Structure for
OR4D2
ECgene alternative splicing isoforms for
OR4D2

Expression for OR4D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4D2 Gene

Protein differential expression in normal tissues from HIPED for OR4D2 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4D2 Gene



Protein tissue co-expression partners for OR4D2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4D2 Gene:

OR4D2

SOURCE GeneReport for Unigene cluster for OR4D2 Gene:

Hs.446879
genes like me logo Genes that share expression patterns with OR4D2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D2 Gene

Orthologs for OR4D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC491108 32
  • 87.47 (n)
-- 33
  • 66 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia LOC788704 32
  • 87.08 (n)
-- 33
  • 83 (a)
OneToMany
-- 33
  • 82 (a)
OneToMany
-- 33
  • 82 (a)
OneToMany
-- 33
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or4d2 49 Olfr463 17 33 32
  • 84.65 (n)
Or4d2b 49 Olfr462 33
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1521 32
  • 84.21 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 78 (a)
ManyToMany
-- 33
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 68 (a)
ManyToMany
-- 33
  • 67 (a)
ManyToMany
-- 33
  • 66 (a)
ManyToMany
-- 33
  • 65 (a)
ManyToMany
-- 33
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 55 (a)
ManyToMany
-- 33
  • 51 (a)
ManyToMany
Species where no ortholog for OR4D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D2 Gene

ENSEMBL:
Gene Tree for OR4D2 (if available)
TreeFam:
Gene Tree for OR4D2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4D2: view image

Paralogs for OR4D2 Gene

(437) SIMAP similar genes for OR4D2 Gene using alignment to 1 proteins:

  • OR4D2_HUMAN
genes like me logo Genes that share paralogs with OR4D2: view

Variants for OR4D2 Gene

Sequence variations from dbSNP and Humsavar for OR4D2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001867558 -- 58,168,796(+) C/T upstream_transcript_variant
rs1001897276 -- 58,169,129(+) G/C upstream_transcript_variant
rs1002570038 -- 58,169,310(+) A/C upstream_transcript_variant
rs1003051718 -- 58,168,942(+) G/C upstream_transcript_variant
rs1004708593 -- 58,168,164(+) C/G/T upstream_transcript_variant

Variation tolerance for OR4D2 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.79; 86.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4D2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR4D2 Gene

Disorders for OR4D2 Gene

Additional Disease Information for OR4D2

No disorders were found for OR4D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D2 Gene

Publications for OR4D2 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 56
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Structural basis of GDP release and gating in G protein coupled Fe2+ transport. (PMID: 19629046) Guilfoyle A … Jormakka M (The EMBO journal 2009) 23 56

Products for OR4D2 Gene

Sources for OR4D2 Gene