Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4D11 Gene

Aliases for OR4D11 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 11 2 3 5
  • Olfactory Receptor 4D11 3 4
  • OR4D11P 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 11 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 11 2
  • Olfactory Receptor OR11-252 Pseudogene 3
  • OR4D11 5

External Ids for OR4D11 Gene

Previous HGNC Symbols for OR4D11 Gene

  • OR4D11P

Previous GeneCards Identifiers for OR4D11 Gene

  • GC11P059047
  • GC11P059027
  • GC11P059271

Summaries for OR4D11 Gene

Entrez Gene Summary for OR4D11 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D11 Gene

OR4D11 (Olfactory Receptor Family 4 Subfamily D Member 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4D10.

UniProtKB/Swiss-Prot Summary for OR4D11 Gene

Gene Wiki entry for OR4D11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4D11 Gene

Genomics for OR4D11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4D11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J059544 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +45.5 45532 8.8 BCLAF1 ZNF207 NCOR1 IKZF1 MYC ZNF600 SSRP1 JUND ZNF580 ZNF592 TRR-TCT3-2 TRV-TAC1-1 TRV-TAC2-1 lnc-OR4D9-1-002 ENSG00000269570 ENSG00000255139 PATL1 LINC02739 FAM111A-DT FAM111A
GH11J059479 Enhancer 0.3 Ensembl 12.6 -23.7 -23676 1.8 CEBPB OR4D11 OR4D6 OR4D9 OR5A1 OR5A2 OR4D10 OR4D8P
GH11J059527 Enhancer 0.3 Ensembl 11.7 +24.7 24725 2.2 POLR2A RNU7-58P OR4D11 OR4D6 OR5A2 OR5A1 STX3 OR4D7P OR4D9 OSBP
GH11J059565 Enhancer 0.3 FANTOM5 4.4 +60.9 60880 0 ZNF384 ENSG00000255139 LINC02739 TRF-GAA2-1 OR5AN1 OR4D11 OR4D6 HSALNG0084418 TRK-TTT3-4 OR4D9 OSBP
GH11J059510 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 +7.5 7525 1 NFE2 ETV1 MAFG ATF4 CEBPB ATF3 EMSY CEBPG OR4D9 OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4D11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4D11

Top Transcription factor binding sites by QIAGEN in the OR4D11 gene promoter:
  • AML1a
  • AP-1
  • C/EBPalpha
  • CHOP-10
  • GATA-2
  • HOXA5
  • Nkx2-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for OR4D11 Gene

Latest Assembly
chr11:59,503,576-59,504,511
(GRCh38/hg38)
Size:
936 bases
Orientation:
Plus strand

Previous Assembly
chr11:59,271,049-59,271,984
(GRCh37/hg19 by Entrez Gene)
Size:
936 bases
Orientation:
Plus strand

chr11:59,271,049-59,271,984
(GRCh37/hg19 by Ensembl)
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR4D11 Gene

Genes around OR4D11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D11 Gene

Proteins for OR4D11 Gene

  • Protein details for OR4D11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI4-OR4DB_HUMAN
    Recommended name:
    Olfactory receptor 4D11
    Protein Accession:
    Q8NGI4

    Protein attributes for OR4D11 Gene

    Size:
    311 amino acids
    Molecular mass:
    34969 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D11 Gene

Post-translational modifications for OR4D11 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D11 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D11 Gene

Domains & Families for OR4D11 Gene

Gene Families for OR4D11 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D11 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4D11 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 4D11 (OR4DB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGI4

UniProtKB/Swiss-Prot:

OR4DB_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D11: view

Function for OR4D11 Gene

Molecular function for OR4D11 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4D11 Gene

Gene Ontology (GO) - Molecular Function for OR4D11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D11: view
genes like me logo Genes that share phenotypes with OR4D11: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4D11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D11 Gene

Localization for OR4D11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D11 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D11 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4D11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D11 Gene

Pathways & Interactions for OR4D11 Gene

genes like me logo Genes that share pathways with OR4D11: view

Pathways by source for OR4D11 Gene

Interacting Proteins for OR4D11 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000320077 Q8NGI4-OR4DB_HUMAN for OR4D11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR4D11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4D11: view

No data available for SIGNOR curated interactions for OR4D11 Gene

Drugs & Compounds for OR4D11 Gene

No Compound Related Data Available

Transcripts for OR4D11 Gene

mRNA/cDNA for OR4D11 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4D11

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D11 Gene

No ASD Table

Relevant External Links for OR4D11 Gene

GeneLoc Exon Structure for
OR4D11

Expression for OR4D11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4D11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4D11

SOURCE GeneReport for Unigene cluster for OR4D11 Gene:

Hs.553651
genes like me logo Genes that share expression patterns with OR4D11: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D11 Gene

Orthologs for OR4D11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466615 29
  • 98.39 (n)
OR4D11 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR4D11 29 30
  • 89.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr321 29
  • 86.45 (n)
Mouse
(Mus musculus)
Mammalia Or4d11 45 Olfr1423 29 16 30
  • 86.24 (n)
OneToOne
Or4d29-ps 45 Olfr1422-ps1
  • chr19:12,021,088-12,021,665
Or4z4 45 Olfr1427
  • chr19:12,098,705-12,099,637
Cow
(Bos Taurus)
Mammalia OR4D11 29
  • 84.31 (n)
-- 30
  • 83 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 80 (a)
ManyToMany
-- 30
  • 77 (a)
ManyToMany
-- 30
  • 77 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 66 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 53 (a)
ManyToMany
-- 30
  • 49 (a)
ManyToMany
Species where no ortholog for OR4D11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4D11 Gene

ENSEMBL:
Gene Tree for OR4D11 (if available)
TreeFam:
Gene Tree for OR4D11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4D11: view image
Alliance of Genome Resources:
Additional Orthologs for OR4D11

Paralogs for OR4D11 Gene

(441) SIMAP similar genes for OR4D11 Gene using alignment to 1 proteins:

  • OR4DB_HUMAN

Pseudogenes.org Pseudogenes for OR4D11 Gene

genes like me logo Genes that share paralogs with OR4D11: view

Variants for OR4D11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4D11 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs386352341 Uncertain Significance: not provided 59,504,150(+) C/A
NM_001004706.1(OR4D11):c.575C>A (p.Thr192Asn)
MISSENSE
rs7120079 -- p.Phe197Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4D11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR4D11 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4D11
Leiden Open Variation Database (LOVD)
OR4D11

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR4D11 Gene

Disorders for OR4D11 Gene

Additional Disease Information for OR4D11

No disorders were found for OR4D11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D11 Gene

Publications for OR4D11 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3

Products for OR4D11 Gene

Sources for OR4D11 Gene