Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4D10 Gene

Aliases for OR4D10 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 10 2 3 5
  • Olfactory Receptor OR11-251 3 4
  • Olfactory Receptor 4D10 3 4
  • OR4D10P 3 4
  • OST711 2 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 10 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 10 2
  • Seven Transmembrane Helix Receptor 3
  • OR11-251 3
  • OR4D10 5

External Ids for OR4D10 Gene

Previous HGNC Symbols for OR4D10 Gene

  • OR4D10P

Previous GeneCards Identifiers for OR4D10 Gene

  • GC11P059021
  • GC11P059001
  • GC11P059244

Summaries for OR4D10 Gene

Entrez Gene Summary for OR4D10 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D10 Gene

OR4D10 (Olfactory Receptor Family 4 Subfamily D Member 10) is a Protein Coding gene. Diseases associated with OR4D10 include Carboxypeptidase N Deficiency and Pick Disease Of Brain. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4D11.

UniProtKB/Swiss-Prot Summary for OR4D10 Gene

Gene Wiki entry for OR4D10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4D10 Gene

Genomics for OR4D10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4D10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J059536 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 10.6 +64.3 64289 1.8 ZNF654 NCOR1 IKZF1 ZNF592 POLR2A NFIC REST TRIM22 TBP ZNF341 ENSG00000287264 HSALNG0084413 LOC102723575 lnc-OR4D9-1-001 OR4D9 OR4D10 OR5A2 OR4D6 OR5AN1 STX3
GH11J059510 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE 11.1 +37.8 37786 1 NFE2 ETV1 MAFG ATF4 CEBPB ATF3 EMSY CEBPG OR4D9 OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D11
GH11J059263 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.4 -204.4 -204414 15.8 BCLAF1 SP1 BCL11A CTCF ZNF592 TRIM22 NR2C1 RAD51 IRF4 SMC3 DTX4 OR5A2 STX3 PATL1 OR4D10 MPEG1 OR4D9 OSBP OR4D6 FAM111A
GH11J059479 Enhancer 0.3 Ensembl 0.4 +6.6 6585 1.8 CEBPB OR4D11 OR4D6 OR4D9 OR5A1 OR5A2 OR4D10 OR4D8P
GH11J059463 Enhancer 0.2 ENCODE 0.4 -9.8 -9782 0 OR5A1 OR5A2 lnc-OR4D10-1 OR4D10 OR4D6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4D10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4D10

Top Transcription factor binding sites by QIAGEN in the OR4D10 gene promoter:
  • aMEF-2
  • AML1a
  • AP-1
  • Lmo2
  • MEF-2A
  • POU2F1
  • RORalpha2
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4D10 Gene

Latest Assembly
chr11:59,473,315-59,479,361
(GRCh38/hg38)
Size:
6,047 bases
Orientation:
Plus strand

Previous Assembly
chr11:59,240,788-59,246,834
(GRCh37/hg19 by Entrez Gene)
Size:
6,047 bases
Orientation:
Plus strand

chr11:59,244,846-59,245,869
(GRCh37/hg19 by Ensembl)
Size:
1,024 bases
Orientation:
Plus strand

Genomic View for OR4D10 Gene

Genes around OR4D10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D10 Gene

Proteins for OR4D10 Gene

  • Protein details for OR4D10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI6-OR4DA_HUMAN
    Recommended name:
    Olfactory receptor 4D10
    Protein Accession:
    Q8NGI6
    Secondary Accessions:
    • B2RNH6

    Protein attributes for OR4D10 Gene

    Size:
    311 amino acids
    Molecular mass:
    35300 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D10 Gene

Post-translational modifications for OR4D10 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D10 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D10 Gene

Domains & Families for OR4D10 Gene

Gene Families for OR4D10 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D10 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4D10 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-251 (OR4DA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGI6

UniProtKB/Swiss-Prot:

OR4DA_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D10: view

Function for OR4D10 Gene

Molecular function for OR4D10 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4D10 Gene

Gene Ontology (GO) - Molecular Function for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4D10: view
genes like me logo Genes that share phenotypes with OR4D10: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4D10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D10 Gene

Localization for OR4D10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D10 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D10 gene
Compartment Confidence
plasma membrane 5
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4D10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D10 Gene

Pathways & Interactions for OR4D10 Gene

genes like me logo Genes that share pathways with OR4D10: view

Pathways by source for OR4D10 Gene

Interacting Proteins for OR4D10 Gene

Gene Ontology (GO) - Biological Process for OR4D10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4D10: view

No data available for SIGNOR curated interactions for OR4D10 Gene

Drugs & Compounds for OR4D10 Gene

No Compound Related Data Available

Transcripts for OR4D10 Gene

mRNA/cDNA for OR4D10 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4D10

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D10 Gene

No ASD Table

Relevant External Links for OR4D10 Gene

GeneLoc Exon Structure for
OR4D10

Expression for OR4D10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4D10 Gene

Protein differential expression in normal tissues from HIPED for OR4D10 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4D10 Gene



Protein tissue co-expression partners for OR4D10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4D10

SOURCE GeneReport for Unigene cluster for OR4D10 Gene:

Hs.553756
genes like me logo Genes that share expression patterns with OR4D10: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D10 Gene

Orthologs for OR4D10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC735830 29
  • 98.93 (n)
OR4D10 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR4D10 30
  • 89 (a)
OneToOne
LOC483451 29
  • 87.35 (n)
Mouse
(Mus musculus)
Mammalia Or4d10 45 Olfr1425 30
  • 86 (a)
OneToMany
Or4d10c 45 Olfr1426 30
  • 85 (a)
OneToMany
Or4d10b 45 Olfr1424 29 16 30
  • 84.87 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 83 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 77 (a)
ManyToMany
-- 30
  • 77 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 68 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
-- 30
  • 53 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 55 (a)
ManyToMany
-- 30
  • 51 (a)
ManyToMany
Species where no ortholog for OR4D10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4D10 Gene

ENSEMBL:
Gene Tree for OR4D10 (if available)
TreeFam:
Gene Tree for OR4D10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4D10: view image
Alliance of Genome Resources:
Additional Orthologs for OR4D10

Paralogs for OR4D10 Gene

(437) SIMAP similar genes for OR4D10 Gene using alignment to 1 proteins:

  • OR4DA_HUMAN
genes like me logo Genes that share paralogs with OR4D10: view

Variants for OR4D10 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4D10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4D10 Gene

Variant ID Type Subtype PubMed ID
esv3626537 CNV loss 21293372
nsv983027 CNV duplication 23825009

Variation tolerance for OR4D10 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4D10
Leiden Open Variation Database (LOVD)
OR4D10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4D10 Gene

Disorders for OR4D10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR4D10 Gene - From: COP

Disorder Aliases PubMed IDs
carboxypeptidase n deficiency
  • anaphylotoxin inactivator deficiency
pick disease of brain
  • lobar atrophy of brain
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR4D10

genes like me logo Genes that share disorders with OR4D10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4D10 Gene

Publications for OR4D10 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 40
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR4D10 Gene

Sources for OR4D10 Gene