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Aliases for OR4D1 Gene

Aliases for OR4D1 Gene

  • Olfactory Receptor Family 4 Subfamily D Member 1 2 3 5
  • Olfactory Receptor TPCR16 3 4
  • Olfactory Receptor 4D3 3 4
  • OR4D3 3 4
  • Olfactory Receptor, Family 4, Subfamily D, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 3 3
  • Olfactory Receptor, Family 4, Subfamily D, Member 1 2
  • Olfactory Receptor OR17-23 Pseudogene 3
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 4D1 3
  • OR17-23 3
  • OR4D4P 3
  • TPCR16 3

External Ids for OR4D1 Gene

Previous HGNC Symbols for OR4D1 Gene

  • OR4D3

Previous GeneCards Identifiers for OR4D1 Gene

  • GC17P055976
  • GC17M058713
  • GC17P056539
  • GC17P056707
  • GC17P053552
  • GC17P053588
  • GC17P056232

Summaries for OR4D1 Gene

Entrez Gene Summary for OR4D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4D1 Gene

OR4D1 (Olfactory Receptor Family 4 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4D2.

UniProtKB/Swiss-Prot for OR4D1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4D1 Gene

Additional gene information for OR4D1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4D1 Gene

Genomics for OR4D1 Gene

GeneHancer (GH) Regulatory Elements for OR4D1 Gene

Promoters and enhancers for OR4D1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058004 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 14.7 -141.9 -141945 4.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 SRSF1 GC17P058008 PIR35824 PIR33066 ENSG00000279069 ENSG00000266086 MKS1 TEX14 ENSG00000264914 OR4D1
GH17J057983 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.6 -160.8 -160836 7.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 VEZF1 ENSG00000280233 LOC101929185 MKS1 TEX14 SRSF1 ENSG00000264914 OR4D1 LOC101927557 SETP3
GH17J058658 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.6 +510.6 510561 2 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC TEX14 GC17M058661 SRSF1 MKS1 SMG8 TRIM37 RAD51C DHX40 VEZF1 SETP3
GH17J058081 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 14.8 -64.8 -64796 4.2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF213 LOC101927666 DYNLL2 OR4D1 ENSG00000264914 SETP3 LOC101927557 TEX14 ENSG00000264112 SRSF1 CCDC182
GH17J058351 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.6 +204.7 204740 3.9 CLOCK ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SUPT4H1 SRSF1 TSPOAP1 MKS1 SMG8 SETP3 OR4D1 ENSG00000264914 LOC101927557 SPDYE22P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4D1 gene promoter:
  • GATA-1
  • p53
  • Spz1
  • Arnt
  • AhR
  • HEN1
  • STAT5B
  • STAT5A
  • Brachyury

Genomic Locations for OR4D1 Gene

Genomic Locations for OR4D1 Gene
11,107 bases
Plus strand
1,024 bases
Plus strand

Genomic View for OR4D1 Gene

Genes around OR4D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4D1 Gene

Proteins for OR4D1 Gene

  • Protein details for OR4D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4D1
    Protein Accession:
    Secondary Accessions:
    • B2RN14
    • Q8NGB1
    • Q96R76

    Protein attributes for OR4D1 Gene

    310 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4D1 Gene

Post-translational modifications for OR4D1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4D1 Gene

Domains & Families for OR4D1 Gene

Gene Families for OR4D1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4D1 Gene

Suggested Antigen Peptide Sequences for OR4D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4D1: view

Function for OR4D1 Gene

Molecular function for OR4D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 4,subfamily D,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR4D1 Gene

Gene Ontology (GO) - Molecular Function for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view
genes like me logo Genes that share phenotypes with OR4D1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4D1 Gene

Localization for OR4D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4D1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,NAS 9119360
genes like me logo Genes that share ontologies with OR4D1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4D1 Gene

Pathways & Interactions for OR4D1 Gene

genes like me logo Genes that share pathways with OR4D1: view

Pathways by source for OR4D1 Gene

Interacting Proteins for OR4D1 Gene

Gene Ontology (GO) - Biological Process for OR4D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4D1: view

No data available for SIGNOR curated interactions for OR4D1 Gene

Drugs & Compounds for OR4D1 Gene

No Compound Related Data Available

Transcripts for OR4D1 Gene

mRNA/cDNA for OR4D1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4D1 Gene

Olfactory receptor, family 4, subfamily D, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4D1 Gene

No ASD Table

Relevant External Links for OR4D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4D1 Gene

Protein differential expression in normal tissues from HIPED for OR4D1 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4D1 Gene

Protein tissue co-expression partners for OR4D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4D1 Gene:


SOURCE GeneReport for Unigene cluster for OR4D1 Gene:

genes like me logo Genes that share expression patterns with OR4D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4D1 Gene

Orthologs for OR4D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR4D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR4D1 34
  • 100 (a)
LOC468418 33
  • 99.46 (n)
(Canis familiaris)
Mammalia OR4D1 34 33
  • 87.31 (n)
(Bos Taurus)
Mammalia LOC788693 33
  • 86.77 (n)
-- 34
  • 85 (a)
-- 34
  • 83 (a)
-- 34
  • 83 (a)
-- 34
  • 79 (a)
(Mus musculus)
Mammalia Or4d1 51 Olfr464 16 34 33
  • 84.3 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
-- 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 56 (a)
-- 34
  • 53 (a)
Species where no ortholog for OR4D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4D1 Gene

Gene Tree for OR4D1 (if available)
Gene Tree for OR4D1 (if available)
Evolutionary constrained regions (ECRs) for OR4D1: view image

Paralogs for OR4D1 Gene

(443) SIMAP similar genes for OR4D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4D1: view

Variants for OR4D1 Gene

Sequence variations from dbSNP and Humsavar for OR4D1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001564022 -- 58,156,254(+) C/T downstream_transcript_variant
rs1002966079 -- 58,154,380(+) A/G upstream_transcript_variant
rs1003102395 -- 58,153,937(+) C/T upstream_transcript_variant
rs1003187797 -- 58,154,714(+) T/G upstream_transcript_variant
rs1004142313 -- 58,154,885(+) G/T upstream_transcript_variant

Variation tolerance for OR4D1 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR4D1 Gene

Disorders for OR4D1 Gene

Additional Disease Information for OR4D1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR4D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4D1 Gene

Publications for OR4D1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58

Products for OR4D1 Gene

Sources for OR4D1 Gene

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