Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4C5 Gene

Aliases for OR4C5 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 5 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 5 Pseudogene 2 3
  • Olfactory Receptor OR11-99 3 4
  • Olfactory Receptor 4C5 3 4
  • OR4C5Q 2 3
  • Olfactory Receptor, Family 4, Subfamily C, Member 5 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 4 Subfamily C Member 5 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 4, Subfamily C, Member 5 2
  • Seven Transmembrane Helix Receptor 3
  • OR4C5P 3
  • OR4C5 5

External Ids for OR4C5 Gene

Previous HGNC Symbols for OR4C5 Gene

  • OR4C5P

Previous GeneCards Identifiers for OR4C5 Gene

  • GC11M048352
  • GC11M048343
  • GC11M048386
  • GC11M049562
  • GC11M049575
  • GC11M055830
  • GC11M056059
  • GC11M056202
  • GC11M059722
  • GC11M050814
  • GC11M051609
  • GC11M052271
  • GC11M052931
  • GC11M053599
  • GC11M054265
  • GC11M054931
  • GC11M055633
  • GC11M061142
  • GC11M063629

Summaries for OR4C5 Gene

Entrez Gene Summary for OR4C5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR4C5 Gene

OR4C5 (Olfactory Receptor Family 4 Subfamily C Member 5) is a Protein Coding gene. Diseases associated with OR4C5 include Gastric Cancer, Hereditary Diffuse. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C12.

UniProtKB/Swiss-Prot Summary for OR4C5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4C5 Gene

Genomics for OR4C5 Gene

Genomic Locations for OR4C5 Gene

Latest Assembly
chr11:48,365,485-48,366,465
(GRCh38/hg38)
Size:
981 bases
Orientation:
Minus strand

Previous Assembly
chr11:48,386,849-48,388,040
(GRCh37/hg19 by Entrez Gene)
Size:
1,192 bases
Orientation:
Minus strand

chr11:48,387,037-48,388,017
(GRCh37/hg19 by Ensembl)
Size:
981 bases
Orientation:
Minus strand

Genomic View for OR4C5 Gene

Genes around OR4C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C5 Gene

No data available for GeneHancer (GH) Regulatory Elements for OR4C5 Gene

Proteins for OR4C5 Gene

  • Protein details for OR4C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGB2-OR4C5_HUMAN
    Recommended name:
    Olfactory receptor 4C5
    Protein Accession:
    Q8NGB2
    Secondary Accessions:
    • Q6IFB2

    Protein attributes for OR4C5 Gene

    Size:
    326 amino acids
    Molecular mass:
    36862 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04748.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4C5 Gene

Post-translational modifications for OR4C5 Gene

  • Glycosylation at Asn29

Other Protein References for OR4C5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C5 Gene

Domains & Families for OR4C5 Gene

Gene Families for OR4C5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4C5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4C5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-99 (OR4C5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGB2

UniProtKB/Swiss-Prot:

OR4C5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C5: view

Function for OR4C5 Gene

Molecular function for OR4C5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C5 Gene

Gene Ontology (GO) - Molecular Function for OR4C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C5: view

Phenotypes for OR4C5 Gene

genes like me logo Genes that share phenotypes with OR4C5: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C5 Gene

Localization for OR4C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4C5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C5 Gene

Pathways & Interactions for OR4C5 Gene

genes like me logo Genes that share pathways with OR4C5: view

Pathways by source for OR4C5 Gene

Interacting Proteins for OR4C5 Gene

Gene Ontology (GO) - Biological Process for OR4C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C5: view

No data available for SIGNOR curated interactions for OR4C5 Gene

Drugs & Compounds for OR4C5 Gene

No Compound Related Data Available

Transcripts for OR4C5 Gene

mRNA/cDNA for OR4C5 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C5 Gene

No ASD Table

Relevant External Links for OR4C5 Gene

GeneLoc Exon Structure for
OR4C5

Expression for OR4C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4C5 Gene

Protein differential expression in normal tissues from HIPED for OR4C5 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4C5 Gene



Protein tissue co-expression partners for OR4C5 Gene

genes like me logo Genes that share expression patterns with OR4C5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C5 Gene

Orthologs for OR4C5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR4C5 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR12E07 30
  • 77 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr1260 30
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 69 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia OR4C5 30
  • 64 (a)
OneToOne
Species where no ortholog for OR4C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4C5 Gene

ENSEMBL:
Gene Tree for OR4C5 (if available)
TreeFam:
Gene Tree for OR4C5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4C5: view image
Alliance of Genome Resources:
Additional Orthologs for OR4C5

Paralogs for OR4C5 Gene

(429) SIMAP similar genes for OR4C5 Gene using alignment to 1 proteins:

  • OR4C5_HUMAN

Pseudogenes.org Pseudogenes for OR4C5 Gene

genes like me logo Genes that share paralogs with OR4C5: view

Variants for OR4C5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4C5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR4C5 Gene

Gene Damage Index Score: 14.39; 96.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4C5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C5
Leiden Open Variation Database (LOVD)
OR4C5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for OR4C5 Gene

Disorders for OR4C5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR4C5 Gene - From: COP

Disorder Aliases PubMed IDs
gastric cancer, hereditary diffuse
  • hdgc
- elite association - COSMIC cancer census association via MalaCards
Search OR4C5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR4C5

genes like me logo Genes that share disorders with OR4C5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4C5 Gene

Publications for OR4C5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4C5 Gene

Sources for OR4C5 Gene