Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4C46 Gene

Aliases for OR4C46 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 46 2 3 5
  • Olfactory Receptor 4C46 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 46 2
  • OR4C46 5

External Ids for OR4C46 Gene

Previous GeneCards Identifiers for OR4C46 Gene

  • GC11P051524
  • GC11P051371

Summaries for OR4C46 Gene

Entrez Gene Summary for OR4C46 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C46 Gene

OR4C46 (Olfactory Receptor Family 4 Subfamily C Member 46) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C13.

UniProtKB/Swiss-Prot Summary for OR4C46 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4C46 Gene

Genomics for OR4C46 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4C46

Top Transcription factor binding sites by QIAGEN in the OR4C46 gene promoter:
  • AML1a
  • Bach2
  • LCR-F1
  • p53
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4C46 Gene

Latest Assembly
chr11:54,603,069-54,603,998
(GRCh38/hg38)
Size:
930 bases
Orientation:
Minus strand

Previous Assembly
chr11:51,515,282-51,516,211
(GRCh37/hg19 by Entrez Gene)
Size:
930 bases
Orientation:
Plus strand

chr11:51,515,282-51,516,211
(GRCh37/hg19 by Ensembl)
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR4C46 Gene

Genes around OR4C46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C46 Gene

Proteins for OR4C46 Gene

  • Protein details for OR4C46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHA9-O4C46_HUMAN
    Recommended name:
    Olfactory receptor 4C46
    Protein Accession:
    A6NHA9

    Protein attributes for OR4C46 Gene

    Size:
    309 amino acids
    Molecular mass:
    34533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C46 Gene

Post-translational modifications for OR4C46 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C46 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C46 Gene

Domains & Families for OR4C46 Gene

Gene Families for OR4C46 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4C46 Gene

Suggested Antigen Peptide Sequences for OR4C46 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 4C46 (O4C46_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NHA9

UniProtKB/Swiss-Prot:

O4C46_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C46: view

Function for OR4C46 Gene

Molecular function for OR4C46 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C46 Gene

Gene Ontology (GO) - Molecular Function for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C46: view
genes like me logo Genes that share phenotypes with OR4C46: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4C46

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C46 Gene

Localization for OR4C46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C46 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C46 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4C46: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C46 Gene

Pathways & Interactions for OR4C46 Gene

genes like me logo Genes that share pathways with OR4C46: view

Pathways by source for OR4C46 Gene

Interacting Proteins for OR4C46 Gene

Gene Ontology (GO) - Biological Process for OR4C46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C46: view

No data available for SIGNOR curated interactions for OR4C46 Gene

Drugs & Compounds for OR4C46 Gene

No Compound Related Data Available

Transcripts for OR4C46 Gene

mRNA/cDNA for OR4C46 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4C46

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C46 Gene

No ASD Table

Relevant External Links for OR4C46 Gene

GeneLoc Exon Structure for
OR4C46

Expression for OR4C46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4C46 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4C46

SOURCE GeneReport for Unigene cluster for OR4C46 Gene:

Hs.553564
genes like me logo Genes that share expression patterns with OR4C46: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C46 Gene

Orthologs for OR4C46 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C46 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia cOR4C43 29
  • 86.84 (n)
-- 30
  • 85 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia OR4C46 29
  • 85.57 (n)
-- 30
  • 80 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
-- 30
  • 77 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr1258 29 16 30
  • 82.13 (n)
ManyToMany
Olfr1257 30
  • 79 (a)
ManyToMany
Olfr1204 30
  • 77 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia LOC100909996 29
  • 81.25 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 80 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 63 (a)
ManyToMany
Species where no ortholog for OR4C46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4C46 Gene

ENSEMBL:
Gene Tree for OR4C46 (if available)
TreeFam:
Gene Tree for OR4C46 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4C46: view image
Alliance of Genome Resources:
Additional Orthologs for OR4C46

Paralogs for OR4C46 Gene

(443) SIMAP similar genes for OR4C46 Gene using alignment to 1 proteins:

  • O4C46_HUMAN
genes like me logo Genes that share paralogs with OR4C46: view

Variants for OR4C46 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4C46 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11246609 Benign: not provided 54,603,136(-) T/Cp.Lys288Arg
NM_001004703.1(OR4C46):c.863A>G (p.Lys288Arg)
MISSENSE
rs74396937 Benign: not provided 54,603,640(-) T/C
NM_001004703.1(OR4C46):c.359A>G (p.His120Arg)
MISSENSE
rs11246607 -- p.Ser240Phe
rs11246608 -- p.Cys252Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4C46 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4C46 Gene

Variant ID Type Subtype PubMed ID
dgv1155n100 CNV gain 25217958
dgv1157n100 CNV gain 25217958
dgv142n27 CNV gain 19166990
dgv1823n54 CNV gain 21841781
dgv1854n54 CNV gain 21841781
esv2751029 CNV gain 17911159
esv3626395 CNV loss 21293372
nsv1039619 CNV gain 25217958
nsv1053373 CNV gain 25217958
nsv554590 CNV gain 21841781
nsv832151 CNV loss 17160897
nsv972023 CNV duplication 23825009

Variation tolerance for OR4C46 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.31; 99.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4C46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C46
Leiden Open Variation Database (LOVD)
OR4C46

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C46 Gene

Disorders for OR4C46 Gene

Additional Disease Information for OR4C46

No disorders were found for OR4C46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C46 Gene

Publications for OR4C46 Gene

  1. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Willer CJ … Global Lipids Genetics Consortium (Nature genetics 2013) 3
  2. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B … Karayiorgou M (Nature genetics 2011) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR4C46 Gene

Sources for OR4C46 Gene