Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4C45 Gene

Aliases for OR4C45 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 45 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 45 2 3
  • Olfactory Receptor 4C45 3 4
  • OR4C45 5

External Ids for OR4C45 Gene

Previous GeneCards Identifiers for OR4C45 Gene

  • GC11U900137
  • GC11P050020
  • GC11M048366
  • GC11P049771
  • GC11P9I0191

Summaries for OR4C45 Gene

Entrez Gene Summary for OR4C45 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C45 Gene

OR4C45 (Olfactory Receptor Family 4 Subfamily C Member 45 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4C5.

UniProtKB/Swiss-Prot Summary for OR4C45 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4C45 Gene

Genomics for OR4C45 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4C45 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J050297 Promoter/Enhancer 1 Ensembl ENCODE 0.1 +265.3 265327 2 MYC SMAD5 ATF1 SUPT5H NRF1 POLR2A L3MBTL2 MEIS2 CREM GMEB1 SEPTIN7P11 HSALNG0084162 LINC02750 lnc-OR4C12-9 TRIM51DP GRM5P1 OR4C45
GH11J050169 Promoter 0.4 Ensembl 0.1 +137.0 137027 0.6 NFIB ENSG00000255442 LOC646797 GRM5P1 SEPTIN7P11 OR4C45
GH11J050079 Enhancer 0.2 Ensembl 0.3 +47.0 47027 0.6 piR-57649-001 piR-47790-003 piR-44275-004 OR4C45
GH11J050119 Enhancer 0.2 Ensembl 0.2 +86.3 86326 0.4 HSALNG0084152 GTF2IP11 HSALNG0084151 lnc-OR4C12-2 OR4C45
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4C45 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4C45

Top Transcription factor binding sites by QIAGEN in the OR4C45 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • Cdc5
  • CUTL1
  • HSF1 (long)
  • HSF1short
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4C45 Gene

Latest Assembly
chr11:50,032,874-50,033,794
(GRCh38/hg38)
Size:
921 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr11(PATCHES):74,500-75,420 (+)

Genomic View for OR4C45 Gene

Genes around OR4C45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C45 Gene

Proteins for OR4C45 Gene

  • Protein details for OR4C45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMZ5-O4C45_HUMAN
    Recommended name:
    Olfactory receptor 4C45
    Protein Accession:
    A6NMZ5

    Protein attributes for OR4C45 Gene

    Size:
    311 amino acids
    Molecular mass:
    35341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C45 Gene

Post-translational modifications for OR4C45 Gene

No Post-translational modifications

Other Protein References for OR4C45 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C45 Gene

Domains & Families for OR4C45 Gene

Gene Families for OR4C45 Gene

Protein Domains for OR4C45 Gene

Suggested Antigen Peptide Sequences for OR4C45 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 4C45 (O4C45_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMZ5

UniProtKB/Swiss-Prot:

O4C45_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C45: view

Function for OR4C45 Gene

Molecular function for OR4C45 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C45 Gene

Gene Ontology (GO) - Molecular Function for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C45: view
genes like me logo Genes that share phenotypes with OR4C45: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4C45

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C45 Gene

Localization for OR4C45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C45 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4C45: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR4C45 Gene

Pathways & Interactions for OR4C45 Gene

genes like me logo Genes that share pathways with OR4C45: view

Pathways by source for OR4C45 Gene

Interacting Proteins for OR4C45 Gene

Gene Ontology (GO) - Biological Process for OR4C45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C45: view

No data available for SIGNOR curated interactions for OR4C45 Gene

Drugs & Compounds for OR4C45 Gene

No Compound Related Data Available

Transcripts for OR4C45 Gene

mRNA/cDNA for OR4C45 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4C45

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C45 Gene

No ASD Table

Relevant External Links for OR4C45 Gene

GeneLoc Exon Structure for
OR4C45

Expression for OR4C45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4C45 Gene

mRNA expression in normal human tissues for OR4C45 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4C45

SOURCE GeneReport for Unigene cluster for OR4C45 Gene:

Hs.554533
genes like me logo Genes that share expression patterns with OR4C45: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C45 Gene

Orthologs for OR4C45 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C45 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100614455 29
  • 99.13 (n)
Dog
(Canis familiaris)
Mammalia LOC483599 29
  • 84.31 (n)
Rat
(Rattus norvegicus)
Mammalia Olr728 29
  • 81.15 (n)
Mouse
(Mus musculus)
Mammalia Or4c52 45 Olfr1263 29 16
  • 80.66 (n)
Or4c126 45 Olfr1261
  • chr2:89,993,395-89,994,312
Or4c127 45 Olfr1262
  • chr2:90,002,408-90,003,319
Species where no ortholog for OR4C45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4C45 Gene

ENSEMBL:
Gene Tree for OR4C45 (if available)
TreeFam:
Gene Tree for OR4C45 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4C45

Paralogs for OR4C45 Gene

(425) SIMAP similar genes for OR4C45 Gene using alignment to 1 proteins:

  • O4C45_HUMAN
genes like me logo Genes that share paralogs with OR4C45: view

Variants for OR4C45 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR4C45 Gene

Variant ID Type Subtype PubMed ID
dgv1128n100 CNV gain 25217958
dgv1134n100 CNV gain 25217958
dgv1813n54 CNV gain 21841781
dgv1814n54 CNV gain 21841781
dgv352e212 CNV gain 25503493
esv33425 CNV gain 17666407
esv34613 CNV gain 17911159
esv3626326 CNV gain 21293372
esv3626329 CNV gain 21293372
esv3892002 CNV gain 25118596
esv3892003 CNV gain 25118596
nsv1048074 CNV gain 25217958
nsv428254 CNV loss 18775914
nsv467876 CNV gain 19166990
nsv511004 OTHER complex 20534489
nsv983017 CNV duplication 23825009

Additional Variant Information for OR4C45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C45
Leiden Open Variation Database (LOVD)
OR4C45

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for OR4C45 Gene

Disorders for OR4C45 Gene

Additional Disease Information for OR4C45

No disorders were found for OR4C45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C45 Gene

Publications for OR4C45 Gene

  1. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith NL … Hayward C (Circulation 2011) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young JM … Trask BJ (American journal of human genetics 2008) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR4C45 Gene

Sources for OR4C45 Gene