Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4C16 Gene

Aliases for OR4C16 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 2 3
  • Olfactory Receptor OR11-135 3 4
  • Olfactory Receptor 4C16 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 (Gene/Pseudogene) 2
  • OR11-135 3

External Ids for OR4C16 Gene

Previous GeneCards Identifiers for OR4C16 Gene

  • GC11U990541
  • GC11P055115
  • GC11P055096
  • GC11P055340

Summaries for OR4C16 Gene

Entrez Gene Summary for OR4C16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR4C16 Gene

OR4C16 (Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with OR4C16 include Dyscalculia. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C11.

UniProtKB/Swiss-Prot Summary for OR4C16 Gene

Gene Wiki entry for OR4C16 Gene

Additional gene information for OR4C16 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4C16 Gene

Genomics for OR4C16 Gene

GeneHancer (GH) Regulatory Elements for OR4C16 Gene

Promoters and enhancers for OR4C16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055430 Enhancer 0.2 FANTOM5 12 -141.8 -141797 0 OR4A10P piR-31432-087 piR-40154-027 lnc-OR4A15-1 lnc-OR4A15-2 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4C16 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4C16

Top Transcription factor binding sites by QIAGEN in the OR4C16 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • NCX
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • POU3F2
  • YY1

Genomic Locations for OR4C16 Gene

Genomic Locations for OR4C16 Gene
chr11:55,572,128-55,573,060
(GRCh38/hg38)
Size:
933 bases
Orientation:
Plus strand
chr11:55,339,604-55,340,536
(GRCh37/hg19)
Size:
933 bases
Orientation:
Plus strand

Genomic View for OR4C16 Gene

Genes around OR4C16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C16 Gene

Proteins for OR4C16 Gene

  • Protein details for OR4C16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL9-OR4CG_HUMAN
    Recommended name:
    Olfactory receptor 4C16
    Protein Accession:
    Q8NGL9
    Secondary Accessions:
    • Q6IEV8

    Protein attributes for OR4C16 Gene

    Size:
    310 amino acids
    Molecular mass:
    34991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C16 Gene

Post-translational modifications for OR4C16 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C16 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C16 Gene

Domains & Families for OR4C16 Gene

Gene Families for OR4C16 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for OR4C16 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR4C16 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-135 (OR4CG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGL9

UniProtKB/Swiss-Prot:

OR4CG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C16: view

Function for OR4C16 Gene

Molecular function for OR4C16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C16 Gene

Gene Ontology (GO) - Molecular Function for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C16: view
genes like me logo Genes that share phenotypes with OR4C16: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C16 Gene

Localization for OR4C16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4C16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C16 Gene

Pathways & Interactions for OR4C16 Gene

genes like me logo Genes that share pathways with OR4C16: view

Pathways by source for OR4C16 Gene

Interacting Proteins for OR4C16 Gene

;

Gene Ontology (GO) - Biological Process for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C16: view

No data available for SIGNOR curated interactions for OR4C16 Gene

Drugs & Compounds for OR4C16 Gene

No Compound Related Data Available

Transcripts for OR4C16 Gene

mRNA/cDNA for OR4C16 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C16 Gene

No ASD Table

Relevant External Links for OR4C16 Gene

GeneLoc Exon Structure for
OR4C16

Expression for OR4C16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4C16 Gene

Protein differential expression in normal tissues from HIPED for OR4C16 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4C16 Gene



Protein tissue co-expression partners for OR4C16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4C16

SOURCE GeneReport for Unigene cluster for OR4C16 Gene:

Hs.553619
genes like me logo Genes that share expression patterns with OR4C16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C16 Gene

Orthologs for OR4C16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466535 30
  • 98.06 (n)
dog
(Canis familiaris)
Mammalia LOC100855716 30
  • 85.27 (n)
cow
(Bos Taurus)
Mammalia LOC532486 30
  • 84.52 (n)
mouse
(Mus musculus)
Mammalia Or4c29 47 Olfr1209 17 30
  • 80.97 (n)
Or4c103 47 Olfr1195
  • chr2:88,682,807-88,683,730
Or4c104 47 Olfr1199
  • chr2:88,755,744-88,756,673
rat
(Rattus norvegicus)
Mammalia Olr662 30
  • 80.32 (n)
Species where no ortholog for OR4C16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C16 Gene

ENSEMBL:
Gene Tree for OR4C16 (if available)
TreeFam:
Gene Tree for OR4C16 (if available)

Paralogs for OR4C16 Gene

(440) SIMAP similar genes for OR4C16 Gene using alignment to 1 proteins:

  • OR4CG_HUMAN
genes like me logo Genes that share paralogs with OR4C16: view

Variants for OR4C16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4C16 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12288690 - p.Ala203Thr
rs12800642 - p.Val25Leu
rs557590 - p.Thr76Ala
rs558465 - p.Thr49Ala
rs559449 - p.Leu259Pro

Additional dbSNP identifiers (rs#s) for OR4C16 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR4C16 Gene

Variant ID Type Subtype PubMed ID
dgv1166n100 CNV gain 25217958
dgv1170n100 CNV loss 25217958
dgv1171n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv12n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv362e212 CNV gain 25503493
dgv4e49 CNV loss 18971310
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv2751032 CNV loss 17911159
esv2759828 CNV gain+loss 17122850
esv3626443 CNV gain 21293372
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv428256 CNV loss 18775914
nsv467886 CNV gain 19166990
nsv517440 CNV gain+loss 19592680
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv554803 CNV gain 21841781
nsv554805 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR4C16 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.19; 96.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4C16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C16 Gene

Disorders for OR4C16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR4C16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dyscalculia
  • disorder of arithmetical skills
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR4C16

genes like me logo Genes that share disorders with OR4C16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR4C16 Gene

Publications for OR4C16 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 54
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  3. Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss. (PMID: 30203366) Ryu CS … Kim NK (Genes & genomics 2019) 3 54
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for OR4C16 Gene

Sources for OR4C16 Gene