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Aliases for OR4C16 Gene

Aliases for OR4C16 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 2 3
  • Olfactory Receptor OR11-135 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 16 (Gene/Pseudogene) 2
  • Olfactory Receptor 4C16 3
  • OR11-135 3

External Ids for OR4C16 Gene

Previous GeneCards Identifiers for OR4C16 Gene

  • GC11U990541
  • GC11P055115
  • GC11P055096
  • GC11P055340

Summaries for OR4C16 Gene

Entrez Gene Summary for OR4C16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR4C16 Gene

OR4C16 (Olfactory Receptor Family 4 Subfamily C Member 16 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C11.

UniProtKB/Swiss-Prot for OR4C16 Gene

  • Odorant receptor.

Gene Wiki entry for OR4C16 Gene

Additional gene information for OR4C16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4C16 Gene

Genomics for OR4C16 Gene

GeneHancer (GH) Regulatory Elements for OR4C16 Gene

Promoters and enhancers for OR4C16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055430 Enhancer 0.2 FANTOM5 12 -141.8 -141797 0 GC11P055433 GC11P055434 OR4A10P OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4C16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4C16 gene promoter:
  • POU3F2
  • NCX
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • YY1
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for OR4C16 Gene

Genomic Locations for OR4C16 Gene
933 bases
Plus strand
933 bases
Plus strand

Genomic View for OR4C16 Gene

Genes around OR4C16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4C16 Gene

Proteins for OR4C16 Gene

  • Protein details for OR4C16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4C16
    Protein Accession:
    Secondary Accessions:
    • Q6IEV8

    Protein attributes for OR4C16 Gene

    310 amino acids
    Molecular mass:
    34991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4C16 Gene

Post-translational modifications for OR4C16 Gene

  • Glycosylation at isoforms=6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C16 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C16 Gene

Domains & Families for OR4C16 Gene

Gene Families for OR4C16 Gene

Protein Domains for OR4C16 Gene

Suggested Antigen Peptide Sequences for OR4C16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C16: view

Function for OR4C16 Gene

Molecular function for OR4C16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C16: view
genes like me logo Genes that share phenotypes with OR4C16: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C16 Gene

Localization for OR4C16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4C16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C16 Gene

Pathways & Interactions for OR4C16 Gene

genes like me logo Genes that share pathways with OR4C16: view

Pathways by source for OR4C16 Gene

Interacting Proteins for OR4C16 Gene

Gene Ontology (GO) - Biological Process for OR4C16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4C16: view

No data available for SIGNOR curated interactions for OR4C16 Gene

Drugs & Compounds for OR4C16 Gene

No Compound Related Data Available

Transcripts for OR4C16 Gene

mRNA/cDNA for OR4C16 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4C16 Gene

Olfactory receptor, family 4, subfamily C, member 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C16 Gene

No ASD Table

Relevant External Links for OR4C16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4C16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4C16 Gene

Protein differential expression in normal tissues from HIPED for OR4C16 Gene

This gene is overexpressed in Liver (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4C16 Gene

Protein tissue co-expression partners for OR4C16 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4C16 Gene:


SOURCE GeneReport for Unigene cluster for OR4C16 Gene:

genes like me logo Genes that share expression patterns with OR4C16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C16 Gene

Orthologs for OR4C16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466535 33
  • 98.06 (n)
(Canis familiaris)
Mammalia LOC100855716 33
  • 85.27 (n)
(Bos Taurus)
Mammalia LOC532486 33
  • 84.52 (n)
(Mus musculus)
Mammalia Or4c29 51 Olfr1209 16 33
  • 80.97 (n)
Or4c103 51 Olfr1195
  • chr2:88,682,807-88,683,730
Or4c104 51 Olfr1199
  • chr2:88,755,744-88,756,673
(Rattus norvegicus)
Mammalia Olr662 33
  • 80.32 (n)
Species where no ortholog for OR4C16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4C16 Gene

Gene Tree for OR4C16 (if available)
Gene Tree for OR4C16 (if available)

Paralogs for OR4C16 Gene

Paralogs for OR4C16 Gene

(440) SIMAP similar genes for OR4C16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR4C16: view

Variants for OR4C16 Gene

Sequence variations from dbSNP and Humsavar for OR4C16 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000463881 -- 55,570,319(+) A/G upstream_transcript_variant
rs1000583896 -- 55,570,428(+) C/T upstream_transcript_variant
rs1001190509 -- 55,571,270(+) AAA/AAAAA upstream_transcript_variant
rs1001414960 -- 55,570,870(+) G/A upstream_transcript_variant
rs1001466878 -- 55,571,056(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4C16 Gene

Variant ID Type Subtype PubMed ID
dgv1166n100 CNV gain 25217958
dgv1170n100 CNV loss 25217958
dgv1171n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv12n68 CNV loss 17160897
dgv143n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1906n54 CNV gain+loss 21841781
dgv362e212 CNV gain 25503493
dgv4e49 CNV loss 18971310
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv2751032 CNV loss 17911159
esv2759828 CNV gain+loss 17122850
esv3626443 CNV gain 21293372
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv428256 CNV loss 18775914
nsv467886 CNV gain 19166990
nsv517440 CNV gain+loss 19592680
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv554803 CNV gain 21841781
nsv554805 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR4C16 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.19; 96.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4C16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4C16 Gene

Disorders for OR4C16 Gene

Additional Disease Information for OR4C16

No disorders were found for OR4C16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C16 Gene

Publications for OR4C16 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4C16 Gene

Sources for OR4C16 Gene

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