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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR4C15 (Olfactory Receptor Family 4 Subfamily C Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C46.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J055430 | Enhancer | 0.2 | FANTOM5 | 15.5 | -123.9 | -123938 | 0 | OR4A10P piR-31432-087 lnc-OR4A15-1 lnc-OR4A15-2 piR-40154-027 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466532 30 |
|
||
OR4C15 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR4C15 31 |
|
OneToOne | |
LOC100684610 30 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Olr663 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or4c15 46 Olfr1211 30 17 31 |
|
OneToMany |
|
Or4c15b 46 Olfr1229 31 |
|
OneToMany |
|
||
Or4c124 46 Olfr1232 31 |
|
OneToMany |
|
||
Or4c107 46 Olfr1212 31 |
|
OneToMany |
|
||
Or4c118 46 Olfr1223 31 |
|
OneToMany |
|
||
Or4c108 46 Olfr1213 31 |
|
OneToMany |
|
||
Or4c117 46 Olfr1222 31 |
|
OneToMany |
|
||
Or4c122 46 Olfr1228 31 |
|
OneToMany |
|
||
Or4c112 46 Olfr1217 31 |
|
OneToMany |
|
||
Olfr1224-ps1 31 |
|
OneToMany | |||
Or4c110 46 Olfr1215 31 |
|
OneToMany |
|
||
Or4c114 46 Olfr1219 31 |
|
OneToMany |
|
||
Or4c121 46 Olfr1226 31 |
|
OneToMany |
|
||
Or4c116 46 Olfr1221 31 |
|
OneToMany |
|
||
Or4c120 46 Olfr1225 31 |
|
OneToMany |
|
||
Or4c115 46 Olfr1220 31 |
|
OneToMany |
|
||
Or4c111 46 Olfr1216 31 |
|
OneToMany |
|
||
Or4c109 46 Olfr1214 31 |
|
OneToMany |
|
||
Or4c113 46 Olfr1218 31 |
|
OneToMany |
|
||
Or4ad1-ps 46 Olfr1227-ps1 |
|
|
|||
Or4ad2-ps 46 Olfr1227-ps1a |
|
|
|||
Or4c119 46 Olfr1224 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1166n100 | CNV | gain | 25217958 |
dgv1170n100 | CNV | loss | 25217958 |
dgv1171n100 | CNV | loss | 25217958 |
dgv1172n100 | CNV | gain | 25217958 |
dgv12n68 | CNV | loss | 17160897 |
dgv1905n54 | CNV | gain | 21841781 |
dgv362e212 | CNV | gain | 25503493 |
esv2751030 | CNV | gain | 17911159 |
esv2751031 | CNV | loss | 17911159 |
esv2751032 | CNV | loss | 17911159 |
esv2759828 | CNV | gain+loss | 17122850 |
esv3626425 | CNV | loss | 21293372 |
esv3626432 | CNV | loss | 21293372 |
esv3626433 | CNV | gain | 21293372 |
esv3892009 | CNV | gain | 25118596 |
nsv1036325 | CNV | gain | 25217958 |
nsv428256 | CNV | loss | 18775914 |
nsv467886 | CNV | gain | 19166990 |
nsv518225 | CNV | loss | 19592680 |
nsv522846 | CNV | gain | 19592680 |
nsv524091 | CNV | gain | 19592680 |
nsv554799 | CNV | gain | 21841781 |
nsv554801 | CNV | loss | 21841781 |
nsv821668 | CNV | loss | 15273396 |
No disorders were found for OR4C15 Gene.