OR4C15 Gene (Protein Coding)

Olfactory Receptor Family 4 Subfamily C Member 15

GC11P055556
GIFtS:
28
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4C15 Gene

Aliases for OR4C15 Gene

  • Olfactory Receptor Family 4 Subfamily C Member 15 2 3 5
  • Olfactory Receptor OR11-127 3 4
  • Olfactory Receptor OR11-134 3 4
  • Olfactory Receptor 4C15 3 4
  • Olfactory Receptor, Family 4, Subfamily C, Member 15 2
  • OR11-127 3
  • OR11-134 3
  • OR4C15 5

External Ids for OR4C15 Gene

Previous GeneCards Identifiers for OR4C15 Gene

  • GC11U990542
  • GC11P055078
  • GC11P055321

Summaries for OR4C15 Gene

Entrez Gene Summary for OR4C15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4C15 Gene

OR4C15 (Olfactory Receptor Family 4 Subfamily C Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4C46.

UniProtKB/Swiss-Prot Summary for OR4C15 Gene

Gene Wiki entry for OR4C15 Gene

Additional gene information for OR4C15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4C15 Gene

Genomics for OR4C15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR4C15 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J055430 Enhancer 0.2 FANTOM5 15.5 -124.0 -123976 0 OR4A10P lnc-OR4A15-1 lnc-OR4A15-2 piR-31432-087 piR-40154-027 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4C15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4C15

Top Transcription factor binding sites by QIAGEN in the OR4C15 gene promoter:
  • FOXD3
  • NCX
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • RORalpha2
  • YY1

Genomic Locations for OR4C15 Gene

Latest Assembly
chr11:55,554,307-55,555,419
(GRCh38/hg38)
Size:
1,113 bases
Orientation:
Plus strand

Previous Assembly
chr11:55,321,745-55,323,092
(GRCh37/hg19 by Entrez Gene)
Size:
1,348 bases
Orientation:
Plus strand

chr11:55,321,783-55,322,895
(GRCh37/hg19 by Ensembl)
Size:
1,113 bases
Orientation:
Plus strand

Genomic View for OR4C15 Gene

Genes around OR4C15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4C15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4C15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR4C15 Gene

Proteins for OR4C15 Gene

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  • Protein details for OR4C15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGM1-OR4CF_HUMAN
    Recommended name:
    Olfactory receptor 4C15
    Protein Accession:
    Q8NGM1
    Secondary Accessions:
    • Q6IFE2

    Protein attributes for OR4C15 Gene

    Size:
    316 amino acids
    Molecular mass:
    35667 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04717.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04718.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4C15 Gene

Post-translational modifications for OR4C15 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4C15 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4C15 Gene

Domains & Families for OR4C15 Gene

Gene Families for OR4C15 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4C15 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4C15 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-134 (OR4CF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGM1

UniProtKB/Swiss-Prot:

OR4CF_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4C15: view

Function for OR4C15 Gene

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  6. Cell Lines for research

Molecular function for OR4C15 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4C15 Gene

Gene Ontology (GO) - Molecular Function for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4C15: view

Phenotypes for OR4C15 Gene

GenomeRNAi human phenotypes for OR4C15:
genes like me logo Genes that share phenotypes with OR4C15: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4C15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4C15 Gene

Localization for OR4C15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4C15 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4C15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4C15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4C15 Gene

Pathways & Interactions for OR4C15 Gene

genes like me logo Genes that share pathways with OR4C15: view

Pathways by source for OR4C15 Gene

1 KEGG pathway for OR4C15 Gene

Interacting Proteins for OR4C15 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000324958 for OR4C15 Gene via STRING

GPS-Prot Interaction Network for OR4C15

Gene Ontology (GO) - Biological Process for OR4C15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4C15: view

No data available for SIGNOR curated interactions for OR4C15 Gene

Drugs & Compounds for OR4C15 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OR4C15 Gene

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mRNA/cDNA for OR4C15 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4C15

Alternative Splicing Database (ASD) splice patterns (SP) for OR4C15 Gene

No ASD Table

Relevant External Links for OR4C15 Gene

GeneLoc Exon Structure for
OR4C15

Expression for OR4C15 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4C15 Gene

mRNA expression in normal human tissues for OR4C15 Gene
mRNA expression by GTEx for OR4C15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4C15

SOURCE GeneReport for Unigene cluster for OR4C15 Gene:

Hs.589003
genes like me logo Genes that share expression patterns with OR4C15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4C15 Gene

Orthologs for OR4C15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4C15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC466532 29
  • 99.37 (n)
OR4C15 30
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OR4C15 30
  • 85 (a)
 OneToOne
LOC100684610 29
  • 65.57 (n)
Rat
(Rattus norvegicus)
 Mammalia Olr663 29
  • 83.07 (n)
Mouse
(Mus musculus)
 Mammalia Or4c15 45 Olfr1211 29 16 30
  • 82.96 (n)
 OneToMany
Or4c15b 45 Olfr1229 30
  • 80 (a)
 OneToMany
Or4c124 45 Olfr1232 30
  • 76 (a)
 OneToMany
Or4c107 45 Olfr1212 30
  • 75 (a)
 OneToMany
Or4c118 45 Olfr1223 30
  • 74 (a)
 OneToMany
Or4c108 45 Olfr1213 30
  • 74 (a)
 OneToMany
Or4c117 45 Olfr1222 30
  • 73 (a)
 OneToMany
Or4c122 45 Olfr1228 30
  • 72 (a)
 OneToMany
Or4c112 45 Olfr1217 30
  • 72 (a)
 OneToMany
Olfr1224-ps1 30
  • 72 (a)
 OneToMany
Or4c110 45 Olfr1215 30
  • 71 (a)
 OneToMany
Or4c114 45 Olfr1219 30
  • 71 (a)
 OneToMany
Or4c121 45 Olfr1226 30
  • 71 (a)
 OneToMany
Or4c116 45 Olfr1221 30
  • 71 (a)
 OneToMany
Or4c120 45 Olfr1225 30
  • 71 (a)
 OneToMany
Or4c115 45 Olfr1220 30
  • 70 (a)
 OneToMany
Or4c111 45 Olfr1216 30
  • 69 (a)
 OneToMany
Or4c109 45 Olfr1214 30
  • 69 (a)
 OneToMany
Or4c113 45 Olfr1218 30
  • 68 (a)
 OneToMany
Or4ad1-ps 45 Olfr1227-ps1
  • chr2:89,226,816-89,227,731
Or4ad2-ps 45 Olfr1227-ps1a
  • chr2:89,242,859-89,243,773
Or4c119 45 Olfr1224
  • chr2:89,156,241-89,157,173
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 74 (a)
 OneToMany
-- 30
  • 73 (a)
 OneToMany
-- 30
  • 73 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 62 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia -- 30
  • 59 (a)
 ManyToMany
Species where no ortholog for OR4C15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4C15 Gene

ENSEMBL:
Gene Tree for OR4C15 (if available)
TreeFam:
Gene Tree for OR4C15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4C15: view image
Alliance of Genome Resources:
Additional Orthologs for OR4C15

Paralogs for OR4C15 Gene

Paralogs for OR4C15 Gene

(445) SIMAP similar genes for OR4C15 Gene using alignment to 1 proteins:

  • OR4CF_HUMAN
genes like me logo Genes that share paralogs with OR4C15: view

Variants for OR4C15 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4C15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4C15 Gene

Variant ID Type Subtype PubMed ID
dgv1166n100 CNV gain 25217958
dgv1170n100 CNV loss 25217958
dgv1171n100 CNV loss 25217958
dgv1172n100 CNV gain 25217958
dgv12n68 CNV loss 17160897
dgv1905n54 CNV gain 21841781
dgv362e212 CNV gain 25503493
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv2751032 CNV loss 17911159
esv2759828 CNV gain+loss 17122850
esv3626425 CNV loss 21293372
esv3626432 CNV loss 21293372
esv3626433 CNV gain 21293372
esv3892009 CNV gain 25118596
nsv1036325 CNV gain 25217958
nsv428256 CNV loss 18775914
nsv467886 CNV gain 19166990
nsv518225 CNV loss 19592680
nsv522846 CNV gain 19592680
nsv524091 CNV gain 19592680
nsv554799 CNV gain 21841781
nsv554801 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR4C15 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.59; 91.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4C15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4C15
Leiden Open Variation Database (LOVD)
OR4C15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4C15 Gene

Disorders for OR4C15 Gene

Additional Disease Information for OR4C15

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR4C15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4C15 Gene

Publications for OR4C15 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

ExternalLinks

View latest publications for OR4C15 gene in Mastermind

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Sources for OR4C15 Gene