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Aliases for OR4B1 Gene

Aliases for OR4B1 Gene

  • Olfactory Receptor Family 4 Subfamily B Member 1 2 3 5
  • Olfactory Receptor OR11-106 3 4
  • OST208 3 4
  • Olfactory Receptor, Family 4, Subfamily B, Member 1 2
  • Olfactory Receptor 4B1 3
  • OR11-106 3

External Ids for OR4B1 Gene

Previous GeneCards Identifiers for OR4B1 Gene

  • GC11U990238
  • GC11P048194

Summaries for OR4B1 Gene

Entrez Gene Summary for OR4B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4B1 Gene

OR4B1 (Olfactory Receptor Family 4 Subfamily B Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4S2.

UniProtKB/Swiss-Prot for OR4B1 Gene

  • Odorant receptor.

Gene Wiki entry for OR4B1 Gene

Additional gene information for OR4B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4B1 Gene

Genomics for OR4B1 Gene

GeneHancer (GH) Regulatory Elements for OR4B1 Gene

Promoters and enhancers for OR4B1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J048103 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -109.6 -109585 7.3 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 IRF4 BRCA1 YY1 ELK1 NUP160 OR4S1 PTPRJ-AS1 PTPRJ OR4B1 PACSIN3 ACP2 MADD C1QTNF4 OR4X2
GH11J048266 Enhancer 0.2 FANTOM5 32.1 +50.0 49976 0 OR4B1 OR4S1 OR4X2 OR4C3 OR4X1
GH11J047869 Enhancer 1 FANTOM5 ENCODE dbSUPER 6.2 -347.0 -347006 1 STAT1 PKNOX1 JUN FEZF1 EP300 ZNF335 PRDM6 JUND POLR2A NR2C2 OR4C3 OR4B1 OR4S1 PTPRJ OR4X2 NUP160 GC11M056189
GH11J047912 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -298.0 -297978 13.2 PKNOX1 SMAD1 FOXA2 SIN3A FEZF1 ZNF766 ZNF143 FOS DEK NFYC NUP160 FNBP4 ENSG00000270060 ENSG00000200090 DDB2 ARFGAP2 KBTBD4 PTPRJ C1QTNF4 MADD
GH11J047850 Enhancer 0.9 FANTOM5 ENCODE 3.4 -365.7 -365749 2 JUN MEF2B ELF1 ATF2 FOSL1 POLR2A IKZF1 EED ETV6 IKZF2 C1QTNF4 MTCH2 OR4S1 OR4B1 OR4X2 OR4C3 NUP160 GC11M056189
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR4B1 gene promoter:
  • NF-YB
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • NF-YA
  • POU6F1 (c2)
  • RSRFC4
  • Chx10

Genomic Locations for OR4B1 Gene

Genomic Locations for OR4B1 Gene
930 bases
Plus strand
971 bases
Plus strand

Genomic View for OR4B1 Gene

Genes around OR4B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4B1 Gene

Proteins for OR4B1 Gene

  • Protein details for OR4B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4B1
    Protein Accession:
    Secondary Accessions:
    • Q6IF75
    • Q96R64

    Protein attributes for OR4B1 Gene

    309 amino acids
    Molecular mass:
    34456 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4B1 Gene

Post-translational modifications for OR4B1 Gene

Other Protein References for OR4B1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4B1 Gene

Domains & Families for OR4B1 Gene

Gene Families for OR4B1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4B1 Gene

Suggested Antigen Peptide Sequences for OR4B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4B1: view

Function for OR4B1 Gene

Molecular function for OR4B1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4B1 Gene

Gene Ontology (GO) - Molecular Function for OR4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4B1: view
genes like me logo Genes that share phenotypes with OR4B1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4B1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4B1 Gene

Localization for OR4B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4B1 Gene

Pathways & Interactions for OR4B1 Gene

genes like me logo Genes that share pathways with OR4B1: view

Pathways by source for OR4B1 Gene

Gene Ontology (GO) - Biological Process for OR4B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4B1: view

No data available for SIGNOR curated interactions for OR4B1 Gene

Drugs & Compounds for OR4B1 Gene

No Compound Related Data Available

Transcripts for OR4B1 Gene

mRNA/cDNA for OR4B1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4B1 Gene

Olfactory receptor, family 4, subfamily B, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4B1

Alternative Splicing Database (ASD) splice patterns (SP) for OR4B1 Gene

No ASD Table

Relevant External Links for OR4B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4B1 Gene

Protein differential expression in normal tissues from HIPED for OR4B1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR4B1 Gene

Protein tissue co-expression partners for OR4B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4B1 Gene:


SOURCE GeneReport for Unigene cluster for OR4B1 Gene:

genes like me logo Genes that share expression patterns with OR4B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4B1 Gene

Orthologs for OR4B1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466510 33
  • 98.81 (n)
OR4B1 34
  • 98 (a)
(Canis familiaris)
Mammalia OR08C02 34 33
  • 86.75 (n)
(Bos Taurus)
Mammalia -- 34
  • 85 (a)
LOC532501 33
  • 84.36 (n)
-- 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Olr737 33
  • 81.91 (n)
(Mus musculus)
Mammalia Or4b1d 51 Olfr32 16 34 33
  • 81.58 (n)
Or4b1b 51 Olfr1272 34
  • 81 (a)
Or4b12 51 Olfr1271 34
  • 79 (a)
Or4b13 51 Olfr142 34
  • 79 (a)
Or4b1 51 Olfr1270
  • chr2:90,149,093-90,150,004
Or4b1c 51 Olfr1273
  • chr2:90,295,966-90,296,859
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
-- 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia OR4B1 34
  • 73 (a)
Species where no ortholog for OR4B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4B1 Gene

Gene Tree for OR4B1 (if available)
Gene Tree for OR4B1 (if available)
Evolutionary constrained regions (ECRs) for OR4B1: view image

Paralogs for OR4B1 Gene

Paralogs for OR4B1 Gene

(453) SIMAP similar genes for OR4B1 Gene using alignment to 1 proteins:

  • OR4B1_HUMAN Pseudogenes for OR4B1 Gene

genes like me logo Genes that share paralogs with OR4B1: view

Variants for OR4B1 Gene

Sequence variations from dbSNP and Humsavar for OR4B1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001004967 -- 48,216,414(+) T/C upstream_transcript_variant
rs1002040993 -- 48,217,349(+) G/C coding_sequence_variant, missense_variant
rs1003230748 -- 48,214,868(+) T/C upstream_transcript_variant
rs1004025195 -- 48,217,611(+) C/G coding_sequence_variant, missense_variant
rs1004873548 -- 48,215,716(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4B1 Gene

Variant ID Type Subtype PubMed ID
dgv1111n100 CNV gain 25217958
dgv1112n100 CNV gain 25217958
dgv198e214 CNV gain 21293372
esv3891986 CNV gain 25118596
nsv1041394 CNV gain 25217958
nsv428253 CNV loss 18775914
nsv467871 CNV gain 19166990
nsv467873 CNV loss 19166990
nsv469953 CNV loss 18288195
nsv554211 CNV gain 21841781
nsv554212 CNV loss 21841781

Variation tolerance for OR4B1 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4B1 Gene

Disorders for OR4B1 Gene

Additional Disease Information for OR4B1

No disorders were found for OR4B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4B1 Gene

Publications for OR4B1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4B1 Gene

Sources for OR4B1 Gene

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