Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4A8 Gene

Aliases for OR4A8 Gene

  • Olfactory Receptor Family 4 Subfamily A Member 8 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 4, Subfamily A, Member 8 Pseudogene 2 3
  • Olfactory Receptor 4A8 3 4
  • OR4A8P 3 4
  • Olfactory Receptor, Family 4, Subfamily A, Member 8 (Gene/Pseudogene) 2
  • Olfactory Receptor OR11-110 4
  • OR4A8 5

External Ids for OR4A8 Gene

Previous HGNC Symbols for OR4A8 Gene

  • OR4A8P

Summaries for OR4A8 Gene

Entrez Gene Summary for OR4A8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR4A8 Gene

OR4A8 (Olfactory Receptor Family 4 Subfamily A Member 8 (Gene/Pseudogene)) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot Summary for OR4A8 Gene

Additional gene information for OR4A8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4A8 Gene

Genomics for OR4A8 Gene

Genomic Locations for OR4A8 Gene

Latest Assembly
chr11:54,682,876-54,683,821
(GRCh38/hg38)
Size:
946 bases
Orientation:
Plus strand

Previous Assembly
chr11:51,435,460-51,436,404
(GRCh37/hg19 by Entrez Gene)
Size:
945 bases
Orientation:
Minus strand

chr11:51,435,459-51,436,403
(GRCh37/hg19 by Ensembl)
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR4A8 Gene

Genes around OR4A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A8 Gene

No data available for GeneHancer (GH) Regulatory Elements for OR4A8 Gene

Proteins for OR4A8 Gene

  • Protein details for OR4A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C604-OR4A8_HUMAN
    Recommended name:
    Olfactory receptor 4A8
    Protein Accession:
    P0C604

    Protein attributes for OR4A8 Gene

    Size:
    315 amino acids
    Molecular mass:
    35621 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4A8 Gene

Post-translational modifications for OR4A8 Gene

  • Glycosylation at Asn6

Other Protein References for OR4A8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for OR4A8 Gene

Domains & Families for OR4A8 Gene

Gene Families for OR4A8 Gene

Protein Domains for OR4A8 Gene

Suggested Antigen Peptide Sequences for OR4A8 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-110 (OR4A8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C604

UniProtKB/Swiss-Prot:

OR4A8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A8: view

Function for OR4A8 Gene

Molecular function for OR4A8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4A8 Gene

Gene Ontology (GO) - Molecular Function for OR4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4A8 Gene

Localization for OR4A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A8 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4A8: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR4A8 Gene

Pathways & Interactions for OR4A8 Gene

PathCards logo

SuperPathways for OR4A8 Gene

genes like me logo Genes that share pathways with OR4A8: view

Pathways by source for OR4A8 Gene

Gene Ontology (GO) - Biological Process for OR4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4A8: view

No data available for Interacting Proteins and SIGNOR curated interactions for OR4A8 Gene

Drugs & Compounds for OR4A8 Gene

No Compound Related Data Available

Transcripts for OR4A8 Gene

mRNA/cDNA for OR4A8 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A8 Gene

No ASD Table

Relevant External Links for OR4A8 Gene

GeneLoc Exon Structure for
OR4A8

Expression for OR4A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4A8 Gene

genes like me logo Genes that share expression patterns with OR4A8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4A8 Gene

Orthologs for OR4A8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A8 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Olfr1238 30
  • 70 (a)
ManyToMany
Olfr1241 30
  • 67 (a)
ManyToMany
Olfr1252 30
  • 67 (a)
ManyToMany
Olfr1250 30
  • 67 (a)
ManyToMany
Olfr1247 30
  • 67 (a)
ManyToMany
Olfr1240 30
  • 67 (a)
ManyToMany
Olfr1245 30
  • 67 (a)
ManyToMany
Olfr1248 30
  • 67 (a)
ManyToMany
Olfr1254 30
  • 67 (a)
ManyToMany
Olfr1246 30
  • 66 (a)
ManyToMany
Olfr1251 30
  • 66 (a)
ManyToMany
Olfr1253 30
  • 66 (a)
ManyToMany
Olfr1243 30
  • 65 (a)
ManyToMany
Olfr1242 30
  • 65 (a)
ManyToMany
Olfr1249 30
  • 65 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia OPOR77 30
  • 66 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 66 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 64 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 63 (a)
OneToMany
Species where no ortholog for OR4A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4A8 Gene

ENSEMBL:
Gene Tree for OR4A8 (if available)
TreeFam:
Gene Tree for OR4A8 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR4A8

Paralogs for OR4A8 Gene

genes like me logo Genes that share paralogs with OR4A8: view

Variants for OR4A8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A8 Gene

OR4A8_HUMAN-P0C604
A stop codon in the gene coding for this protein at position Arg-136 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Additional Variant Information for OR4A8 Gene

Human Gene Mutation Database (HGMD)
OR4A8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4A8
Leiden Open Variation Database (LOVD)
OR4A8

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR4A8 Gene

Disorders for OR4A8 Gene

No disorders were found for OR4A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR4A8 Gene

Publications for OR4A8 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 3 4
  4. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y … Lancet D (Molecular biology and evolution 2003) 3 4
  5. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3

Products for OR4A8 Gene

Sources for OR4A8 Gene