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Aliases for OR4A5 Gene

Aliases for OR4A5 Gene

  • Olfactory Receptor Family 4 Subfamily A Member 5 2 3 5
  • Olfactory Receptor OR11-111 3 4
  • Olfactory Receptor, Family 4, Subfamily A, Member 5 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 4A5 3
  • OR11-111 3

External Ids for OR4A5 Gene

Previous GeneCards Identifiers for OR4A5 Gene

  • GC11U990551
  • GC11M051268
  • GC11M049961
  • GC11M051411

Summaries for OR4A5 Gene

Entrez Gene Summary for OR4A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A5 Gene

OR4A5 (Olfactory Receptor Family 4 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A8.

UniProtKB/Swiss-Prot for OR4A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR4A5 Gene

Additional gene information for OR4A5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR4A5 Gene

Genomics for OR4A5 Gene

GeneHancer (GH) Regulatory Elements for OR4A5 Gene

Top Transcription factor binding sites by QIAGEN in the OR4A5 gene promoter:
  • AREB6
  • POU2F1a
  • POU2F1
  • AML1a
  • Pax-6
  • CUTL1
  • GATA-1
  • C/EBPbeta
  • FOXI1
  • HFH-3

Genomic Locations for OR4A5 Gene

Genomic Locations for OR4A5 Gene
1,071 bases
Plus strand
1,071 bases
Minus strand

Genomic View for OR4A5 Gene

Genes around OR4A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A5 Gene

Proteins for OR4A5 Gene

  • Protein details for OR4A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 4A5
    Protein Accession:
    Secondary Accessions:
    • Q6IF84

    Protein attributes for OR4A5 Gene

    315 amino acids
    Molecular mass:
    34915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4A5 Gene

Post-translational modifications for OR4A5 Gene

  • Glycosylation at isoforms=6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4A5 Gene

Domains & Families for OR4A5 Gene

Gene Families for OR4A5 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4A5 Gene

Suggested Antigen Peptide Sequences for OR4A5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A5: view

Function for OR4A5 Gene

Molecular function for OR4A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4A5 Gene

Gene Ontology (GO) - Molecular Function for OR4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A5: view
genes like me logo Genes that share phenotypes with OR4A5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4A5 Gene

Localization for OR4A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR4A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4A5 Gene

Pathways & Interactions for OR4A5 Gene

genes like me logo Genes that share pathways with OR4A5: view

Pathways by source for OR4A5 Gene

Gene Ontology (GO) - Biological Process for OR4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR4A5: view

No data available for SIGNOR curated interactions for OR4A5 Gene

Drugs & Compounds for OR4A5 Gene

No Compound Related Data Available

Transcripts for OR4A5 Gene

mRNA/cDNA for OR4A5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR4A5 Gene

Olfactory receptor, family 4, subfamily A, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A5 Gene

No ASD Table

Relevant External Links for OR4A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR4A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4A5 Gene:


SOURCE GeneReport for Unigene cluster for OR4A5 Gene:

genes like me logo Genes that share expression patterns with OR4A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4A5 Gene

Orthologs for OR4A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC746837 33
  • 87.9 (n)
(Canis familiaris)
Mammalia LOC100683738 33
  • 82.28 (n)
(Mus musculus)
Mammalia Olfr1238 16 34 33
  • 80.37 (n)
Olfr1247 34
  • 71 (a)
Olfr1248 34
  • 70 (a)
Olfr1245 34
  • 70 (a)
Olfr1250 34
  • 70 (a)
Olfr1252 34
  • 70 (a)
Olfr1241 34
  • 69 (a)
Olfr1246 34
  • 68 (a)
Olfr1254 34
  • 68 (a)
Olfr1251 34
  • 68 (a)
Olfr1240 34
  • 68 (a)
Olfr1253 34
  • 68 (a)
Olfr1243 34
  • 68 (a)
Olfr1242 34
  • 67 (a)
Olfr1249 34
  • 67 (a)
(Monodelphis domestica)
Mammalia OPOR77 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
(Bos Taurus)
Mammalia -- 34
  • 61 (a)
Species where no ortholog for OR4A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4A5 Gene

Gene Tree for OR4A5 (if available)
Gene Tree for OR4A5 (if available)
Evolutionary constrained regions (ECRs) for OR4A5: view image

Paralogs for OR4A5 Gene

(447) SIMAP similar genes for OR4A5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR4A5: view

Variants for OR4A5 Gene

Sequence variations from dbSNP and Humsavar for OR4A5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001309389 -- 54,706,584(+) G/A/T upstream_transcript_variant
rs1002987923 -- 54,705,747(+) C/T upstream_transcript_variant
rs1003103442 -- 54,705,875(+) G/T upstream_transcript_variant
rs1003661504 -- 54,708,136(+) G/A downstream_transcript_variant
rs1003755882 -- 54,705,126(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4A5 Gene

Variant ID Type Subtype PubMed ID
dgv1155n100 CNV gain 25217958
dgv1157n100 CNV gain 25217958
dgv142n27 CNV gain 19166990
dgv1823n54 CNV gain 21841781
dgv1854n54 CNV gain 21841781
esv2751029 CNV gain 17911159
esv3578849 CNV gain 25503493
esv3578860 CNV gain 25503493
nsv1053373 CNV gain 25217958
nsv554487 CNV gain 21841781
nsv554590 CNV gain 21841781
nsv832151 CNV loss 17160897
nsv975921 CNV duplication 23825009
nsv983019 CNV duplication 23825009

Variation tolerance for OR4A5 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A5 Gene

Disorders for OR4A5 Gene

Additional Disease Information for OR4A5

No disorders were found for OR4A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4A5 Gene

Publications for OR4A5 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR4A5 Gene

Sources for OR4A5 Gene

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