Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4A5 Gene

Aliases for OR4A5 Gene

  • Olfactory Receptor Family 4 Subfamily A Member 5 2 3 5
  • Olfactory Receptor OR11-111 3 4
  • Olfactory Receptor 4A5 3 4
  • Olfactory Receptor, Family 4, Subfamily A, Member 5 2
  • Seven Transmembrane Helix Receptor 3
  • OR11-111 3
  • OR4A5 5

External Ids for OR4A5 Gene

Previous GeneCards Identifiers for OR4A5 Gene

  • GC11U990551
  • GC11M051268
  • GC11M049961
  • GC11M051411

Summaries for OR4A5 Gene

Entrez Gene Summary for OR4A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A5 Gene

OR4A5 (Olfactory Receptor Family 4 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A8.

UniProtKB/Swiss-Prot Summary for OR4A5 Gene

Gene Wiki entry for OR4A5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4A5 Gene

Genomics for OR4A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR4A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055262 Promoter 0.3 EPDnew 0 +555.3 555304 0.1 TRIM48 piR-58808-022 OR4A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR4A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR4A5

Top Transcription factor binding sites by QIAGEN in the OR4A5 gene promoter:
  • AML1a
  • AREB6
  • C/EBPbeta
  • CUTL1
  • FOXI1
  • GATA-1
  • HFH-3
  • Pax-6
  • POU2F1
  • POU2F1a

Genomic Locations for OR4A5 Gene

Latest Assembly
chr11:54,706,832-54,707,902
(GRCh38/hg38)
Size:
1,071 bases
Orientation:
Plus strand

Previous Assembly
chr11:51,411,378-51,412,448
(GRCh37/hg19 by Entrez Gene)
Size:
1,071 bases
Orientation:
Minus strand

chr11:51,411,378-51,412,448
(GRCh37/hg19 by Ensembl)
Size:
1,071 bases
Orientation:
Minus strand

Genomic View for OR4A5 Gene

Genes around OR4A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR4A5 Gene

Proteins for OR4A5 Gene

  • Protein details for OR4A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH83-OR4A5_HUMAN
    Recommended name:
    Olfactory receptor 4A5
    Protein Accession:
    Q8NH83
    Secondary Accessions:
    • Q6IF84

    Protein attributes for OR4A5 Gene

    Size:
    315 amino acids
    Molecular mass:
    34915 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR4A5 Gene

Post-translational modifications for OR4A5 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4A5 Gene

Domains & Families for OR4A5 Gene

Gene Families for OR4A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4A5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR4A5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 4, subfamily A, member 5 (B9EIN5_HUMAN)
  • Olfactory receptor OR11-111 (OR4A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH83

UniProtKB/Swiss-Prot:

OR4A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A5: view

Function for OR4A5 Gene

Molecular function for OR4A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4A5 Gene

Gene Ontology (GO) - Molecular Function for OR4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A5: view
genes like me logo Genes that share phenotypes with OR4A5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4A5 Gene

Localization for OR4A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4A5 Gene

Pathways & Interactions for OR4A5 Gene

genes like me logo Genes that share pathways with OR4A5: view

Pathways by source for OR4A5 Gene

Interacting Proteins for OR4A5 Gene

Gene Ontology (GO) - Biological Process for OR4A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4A5: view

No data available for SIGNOR curated interactions for OR4A5 Gene

Drugs & Compounds for OR4A5 Gene

No Compound Related Data Available

Transcripts for OR4A5 Gene

mRNA/cDNA for OR4A5 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR4A5

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A5 Gene

No ASD Table

Relevant External Links for OR4A5 Gene

GeneLoc Exon Structure for
OR4A5

Expression for OR4A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR4A5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR4A5

SOURCE GeneReport for Unigene cluster for OR4A5 Gene:

Hs.554531
genes like me logo Genes that share expression patterns with OR4A5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4A5 Gene

Orthologs for OR4A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC746837 29
  • 87.9 (n)
Dog
(Canis familiaris)
Mammalia LOC100683738 29
  • 82.28 (n)
Mouse
(Mus musculus)
Mammalia Olfr1238 29 16 30
  • 80.37 (n)
ManyToMany
Olfr1247 30
  • 71 (a)
ManyToMany
Olfr1248 30
  • 70 (a)
ManyToMany
Olfr1245 30
  • 70 (a)
ManyToMany
Olfr1250 30
  • 70 (a)
ManyToMany
Olfr1252 30
  • 70 (a)
ManyToMany
Olfr1241 30
  • 69 (a)
ManyToMany
Olfr1246 30
  • 68 (a)
ManyToMany
Olfr1254 30
  • 68 (a)
ManyToMany
Olfr1251 30
  • 68 (a)
ManyToMany
Olfr1240 30
  • 68 (a)
ManyToMany
Olfr1253 30
  • 68 (a)
ManyToMany
Olfr1243 30
  • 68 (a)
ManyToMany
Olfr1242 30
  • 67 (a)
ManyToMany
Olfr1249 30
  • 67 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia OPOR77 30
  • 68 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 67 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 61 (a)
ManyToMany
Species where no ortholog for OR4A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR4A5 Gene

ENSEMBL:
Gene Tree for OR4A5 (if available)
TreeFam:
Gene Tree for OR4A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4A5: view image
Alliance of Genome Resources:
Additional Orthologs for OR4A5

Paralogs for OR4A5 Gene

(447) SIMAP similar genes for OR4A5 Gene using alignment to 2 proteins:

  • OR4A5_HUMAN
  • B9EIN5_HUMAN
genes like me logo Genes that share paralogs with OR4A5: view

Variants for OR4A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR4A5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10902343 -- p.Asn6Ser
rs35083184 -- p.Leu219Gln
rs56302591 -- p.Lys23Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR4A5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR4A5 Gene

Variant ID Type Subtype PubMed ID
dgv1155n100 CNV gain 25217958
dgv1157n100 CNV gain 25217958
dgv142n27 CNV gain 19166990
dgv1823n54 CNV gain 21841781
dgv1854n54 CNV gain 21841781
esv2751029 CNV gain 17911159
esv3578849 CNV gain 25503493
esv3578860 CNV gain 25503493
nsv1053373 CNV gain 25217958
nsv554487 CNV gain 21841781
nsv554590 CNV gain 21841781
nsv832151 CNV loss 17160897
nsv975921 CNV duplication 23825009
nsv983019 CNV duplication 23825009

Variation tolerance for OR4A5 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4A5
Leiden Open Variation Database (LOVD)
OR4A5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A5 Gene

Disorders for OR4A5 Gene

Additional Disease Information for OR4A5

No disorders were found for OR4A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4A5 Gene

Publications for OR4A5 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR4A5 Gene

Sources for OR4A5 Gene