OR4A15 Gene (Protein Coding)

Olfactory Receptor Family 4 Subfamily A Member 15

GC11P055367
GIFtS:
28
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR4A15 Gene

Aliases for OR4A15 Gene

  • Olfactory Receptor Family 4 Subfamily A Member 15 2 3 5
  • Olfactory Receptor OR11-118 3 4
  • Olfactory Receptor 4A15 3 4
  • Olfactory Receptor, Family 4, Subfamily A, Member 15 2
  • OR11-118 3

External Ids for OR4A15 Gene

Previous GeneCards Identifiers for OR4A15 Gene

  • GC11U990561
  • GC11P054892
  • GC11P055135

Summaries for OR4A15 Gene

Entrez Gene Summary for OR4A15 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR4A15 Gene

OR4A15 (Olfactory Receptor Family 4 Subfamily A Member 15) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A5.

UniProtKB/Swiss-Prot Summary for OR4A15 Gene

Gene Wiki entry for OR4A15 Gene

Additional gene information for OR4A15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR4A15 Gene

Genomics for OR4A15 Gene

GeneHancer (GH) Regulatory Elements for OR4A15 Gene


Top Transcription factor binding sites by QIAGEN in the OR4A15 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • POU3F2
  • SRF
  • SRF (504 AA)

Genomic Locations for OR4A15 Gene

Genomic Locations for OR4A15 Gene
chr11:55,367,884-55,368,918
(GRCh38/hg38)
Size:
1,035 bases
Orientation:
Plus strand
chr11:55,135,360-55,136,394
(GRCh37/hg19)
Size:
1,035 bases
Orientation:
Plus strand

Genomic View for OR4A15 Gene

Genes around OR4A15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR4A15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR4A15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR4A15 Gene

Proteins for OR4A15 Gene

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  • Protein details for OR4A15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL6-O4A15_HUMAN
    Recommended name:
    Olfactory receptor 4A15
    Protein Accession:
    Q8NGL6
    Secondary Accessions:
    • Q6IFL4
    • Q96R65

    Protein attributes for OR4A15 Gene

    Size:
    344 amino acids
    Molecular mass:
    38828 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04646.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR4A15 Gene

Post-translational modifications for OR4A15 Gene

  • Glycosylation at Asn36 and Asn290
  • Modification sites at PhosphoSitePlus

Other Protein References for OR4A15 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR4A15 Gene

Domains & Families for OR4A15 Gene

Gene Families for OR4A15 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR4A15 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR4A15 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-118 (O4A15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGL6

UniProtKB/Swiss-Prot:

O4A15_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR4A15: view

Function for OR4A15 Gene

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Molecular function for OR4A15 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR4A15 Gene

Gene Ontology (GO) - Molecular Function for OR4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR4A15: view
genes like me logo Genes that share phenotypes with OR4A15: view

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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR4A15 Gene

Localization for OR4A15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR4A15 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR4A15 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR4A15: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR4A15 Gene

Pathways & Interactions for OR4A15 Gene

genes like me logo Genes that share pathways with OR4A15: view

Pathways by source for OR4A15 Gene

1 KEGG pathway for OR4A15 Gene

Interacting Proteins for OR4A15 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000325065 Q8NGL6-O4A15_HUMAN for OR4A15 Gene via STRING IID

GPS-Prot Interaction Network for OR4A15

Gene Ontology (GO) - Biological Process for OR4A15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR4A15: view

No data available for SIGNOR curated interactions for OR4A15 Gene

Drugs & Compounds for OR4A15 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR4A15 Gene

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mRNA/cDNA for OR4A15 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR4A15 Gene

No ASD Table

Relevant External Links for OR4A15 Gene

GeneLoc Exon Structure for
OR4A15
ECgene alternative splicing isoforms for
OR4A15

Expression for OR4A15 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR4A15 Gene

mRNA expression in normal human tissues for OR4A15 Gene
mRNA expression by GTEx for OR4A15 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR4A15 Gene:

OR4A15

SOURCE GeneReport for Unigene cluster for OR4A15 Gene:

Hs.554529
genes like me logo Genes that share expression patterns with OR4A15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR4A15 Gene

Orthologs for OR4A15 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR4A15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC466527 32
  • 97.97 (n)
OR4A15 33
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cOR4C1P 32
  • 84.71 (n)
OR4A15 33
  • 81 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Olr697 32
  • 84.16 (n)
mouse
(Mus musculus)
 Mammalia Or4a15 49 Olfr1234 17 33 32
  • 82.7 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 71 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia OPOR77 33
  • 68 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia -- 33
  • 67 (a)
 ManyToMany
Species where no ortholog for OR4A15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR4A15 Gene

ENSEMBL:
Gene Tree for OR4A15 (if available)
TreeFam:
Gene Tree for OR4A15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR4A15: view image

Paralogs for OR4A15 Gene

Paralogs for OR4A15 Gene

(443) SIMAP similar genes for OR4A15 Gene using alignment to 1 proteins:

  • O4A15_HUMAN

Pseudogenes.org Pseudogenes for OR4A15 Gene

genes like me logo Genes that share paralogs with OR4A15: view

Variants for OR4A15 Gene

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Sequence variations from dbSNP and Humsavar for OR4A15 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000603929 -- 55,366,515(+) A/C upstream_transcript_variant
rs1000619835 -- 55,367,305(+) T/C upstream_transcript_variant
rs1000903120 -- 55,366,676(+) T/C upstream_transcript_variant
rs1006510539 -- 55,366,085(+) C/A upstream_transcript_variant
rs1006806797 -- 55,366,217(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR4A15 Gene

Variant ID Type Subtype PubMed ID
dgv1164n100 CNV gain 25217958
dgv1166n100 CNV gain 25217958
dgv1168n100 CNV loss 25217958
dgv1905n54 CNV gain 21841781
dgv362e212 CNV gain 25503493
dgv68n21 CNV loss 19592680
esv2751030 CNV gain 17911159
esv2751031 CNV loss 17911159
esv3626425 CNV loss 21293372
esv3626428 CNV loss 21293372
esv3626429 CNV gain 21293372
esv3892009 CNV gain 25118596
esv3892011 CNV loss 25118596
esv998925 CNV deletion 20482838
nsv1036325 CNV gain 25217958
nsv1043928 CNV loss 25217958
nsv1051199 CNV loss 25217958
nsv467886 CNV gain 19166990
nsv524091 CNV gain 19592680
nsv554798 CNV loss 21841781
nsv554799 CNV gain 21841781
nsv825891 CNV loss 20364138
nsv832153 CNV loss 17160897

Variation tolerance for OR4A15 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR4A15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR4A15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR4A15 Gene

Disorders for OR4A15 Gene

Additional Disease Information for OR4A15

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR4A15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR4A15 Gene

Publications for OR4A15 Gene

  1. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung SA … Criswell LA (PLoS genetics 2011) 3 43 56
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 56

ExternalLinks

View latest publications for OR4A15 gene in Mastermind

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