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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR4A15 (Olfactory Receptor Family 4 Subfamily A Member 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR4A5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J055430 | Enhancer | 0.2 | FANTOM5 | 0.2 | +62.4 | 62447 | 0 | OR4A10P piR-31432-087 lnc-OR4A15-1 lnc-OR4A15-2 piR-40154-027 piR-52261-044 piR-49423-041 OR5D14 OR5D18 OR4C15 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004888 | transmembrane signaling receptor activity | IBA | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466527 30 |
|
||
OR4A15 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | cOR4C1P 30 |
|
||
OR4A15 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Olr697 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or4a15 46 Olfr1234 30 17 31 |
|
OneToOne |
|
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | OPOR77 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1164n100 | CNV | gain | 25217958 |
dgv1166n100 | CNV | gain | 25217958 |
dgv1168n100 | CNV | loss | 25217958 |
dgv1905n54 | CNV | gain | 21841781 |
dgv362e212 | CNV | gain | 25503493 |
dgv68n21 | CNV | loss | 19592680 |
esv2751030 | CNV | gain | 17911159 |
esv2751031 | CNV | loss | 17911159 |
esv3626425 | CNV | loss | 21293372 |
esv3626428 | CNV | loss | 21293372 |
esv3626429 | CNV | gain | 21293372 |
esv3892009 | CNV | gain | 25118596 |
esv3892011 | CNV | loss | 25118596 |
esv998925 | CNV | deletion | 20482838 |
nsv1036325 | CNV | gain | 25217958 |
nsv1043928 | CNV | loss | 25217958 |
nsv1051199 | CNV | loss | 25217958 |
nsv467886 | CNV | gain | 19166990 |
nsv524091 | CNV | gain | 19592680 |
nsv554798 | CNV | loss | 21841781 |
nsv554799 | CNV | gain | 21841781 |
nsv825891 | CNV | loss | 20364138 |
nsv832153 | CNV | loss | 17160897 |
No disorders were found for OR4A15 Gene.