Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is transcribed and contains an intact ORF, but it is predicted to be a pseudogene due to a poorly conserved 7-transmembrane domain structure. [provided by RefSeq, Sep 2008]
OR3A4P (Olfactory Receptor Family 3 Subfamily A Member 4 Pseudogene) is a Pseudogene. Diseases associated with OR3A4P include Gastric Cancer and Breast Cancer. Among its related pathways are Peptide ligand-binding receptors.
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
This gene was present in the common ancestor of human and mouse.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Or3a4 46 Olfr399 |
|
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2660206 | CNV | deletion | 23128226 |
esv2674191 | CNV | deletion | 23128226 |
esv3639742 | CNV | loss | 21293372 |
esv3892949 | CNV | loss | 25118596 |
esv3892950 | CNV | loss | 25118596 |
nsv1060926 | CNV | gain | 25217958 |
nsv1065489 | CNV | gain | 25217958 |
nsv457638 | CNV | gain | 19166990 |
nsv457639 | CNV | gain | 19166990 |
nsv470570 | CNV | gain | 18288195 |
nsv520474 | CNV | loss | 19592680 |
nsv574232 | CNV | gain | 21841781 |
nsv574233 | CNV | gain | 21841781 |
nsv574234 | CNV | gain | 21841781 |
nsv574235 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastric cancer |
|
|
breast cancer |
|