OR3A4P Gene (Pseudogene)

Olfactory Receptor Family 3 Subfamily A Member 4 Pseudogene

GC17P003310
GIFtS:
19
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR3A4P Gene

Aliases for OR3A4P Gene

  • Olfactory Receptor Family 3 Subfamily A Member 4 Pseudogene 2 3 5
  • Olfactory Receptor, Family 3, Subfamily A, Member 4 2 3
  • OR17-24 3 4
  • OR3A5P 3 4
  • OR3A4 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 4 Pseudogene 2
  • Olfactory Receptor, Family 3, Subfamily A, Member 5 Pseudogene 3
  • Olfactory Receptor OR17-13 Pseudogene 3
  • Olfactory Receptor OR17-16 Pseudogene 3
  • Putative Olfactory Receptor 3A4 4
  • Olfactory Receptor 17-24 4
  • Olfactory Receptor 3A5 4
  • OLFRA05 3
  • OLFRA06 3
  • OR17-13 3
  • OR17-16 3
  • OR17-25 3
  • OR3A4P 5
  • OR24 3
  • OR25 3

External Ids for OR3A4P Gene

Previous HGNC Symbols for OR3A4P Gene

  • OR3A4

Previous GeneCards Identifiers for OR3A4P Gene

  • GC17P003214
  • GC17P003216
  • GC17P003222
  • GC17P003228
  • GC17P003233

Summaries for OR3A4P Gene

Entrez Gene Summary for OR3A4P Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is transcribed and contains an intact ORF, but it is predicted to be a pseudogene due to a poorly conserved 7-transmembrane domain structure. [provided by RefSeq, Sep 2008]

GeneCards Summary for OR3A4P Gene

OR3A4P (Olfactory Receptor Family 3 Subfamily A Member 4 Pseudogene) is a Pseudogene. Diseases associated with OR3A4P include Gastric Cancer and Breast Cancer. Among its related pathways are Peptide ligand-binding receptors.

UniProtKB/Swiss-Prot Summary for OR3A4P Gene

Gene Wiki entry for OR3A4P Gene

Additional gene information for OR3A4P Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR3A4P Gene

Genomics for OR3A4P Gene

Genomic Locations for OR3A4P Gene

Genomic Locations for OR3A4P Gene
chr17:3,309,986-3,311,446
(GRCh38/hg38)
Size:
1,461 bases
Orientation:
Plus strand
chr17:3,213,539-3,214,740
(GRCh37/hg19)
Size:
1,202 bases
Orientation:
Plus strand

Genomic View for OR3A4P Gene

Genes around OR3A4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A4P Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR3A4P Gene

No data available for GeneHancer (GH) Regulatory Elements for OR3A4P Gene

Proteins for OR3A4P Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OR3A4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47883-OR3A4_HUMAN
    Recommended name:
    Putative olfactory receptor 3A4
    Protein Accession:
    P47883
    Secondary Accessions:
    • Q96R24

    Protein attributes for OR3A4P Gene

    Size:
    348 amino acids
    Molecular mass:
    37194 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A4P Gene

Post-translational modifications for OR3A4P Gene

  • Glycosylation at Asn8

No data available for DME Specific Peptides for OR3A4P Gene

Domains & Families for OR3A4P Gene

Gene Families for OR3A4P Gene

HGNC:

Protein Domains for OR3A4P Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR3A4P Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 3A5 (OR3A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47883

UniProtKB/Swiss-Prot:

OR3A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A4P: view

Function for OR3A4P Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for OR3A4P Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 4,pseudogene,G protein coupled receptor superfamily
genes like me logo Genes that share phenotypes with OR3A4P: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR3A4P

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR3A4P Gene

Localization for OR3A4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A4P Gene

Cell membrane. Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for OR3A4P Gene

Pathways & Interactions for OR3A4P Gene

PathCards logo

SuperPathways for OR3A4P Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
GPCRs, Class A Rhodopsin-like
.42
genes like me logo Genes that share pathways with OR3A4P: view

Pathways by source for OR3A4P Gene

1 BioSystems pathway for OR3A4P Gene

Gene Ontology (GO) - Biological Process for OR3A4P Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for OR3A4P Gene

Drugs & Compounds for OR3A4P Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR3A4P Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OR3A4P Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR3A4P

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A4P Gene

No ASD Table

Relevant External Links for OR3A4P Gene

GeneLoc Exon Structure for
OR3A4P

Expression for OR3A4P Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR3A4P Gene

mRNA expression in normal human tissues for OR3A4P Gene
mRNA expression by GTEx for OR3A4P Gene

mRNA differential expression in normal tissues according to GTEx for OR3A4P Gene

This gene is overexpressed in Testis (x31.9), Brain - Caudate (basal ganglia) (x7.7), Cervix - Ectocervix (x6.8), and Cervix - Endocervix (x6.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR3A4P

SOURCE GeneReport for Unigene cluster for OR3A4P Gene:

Hs.632245
genes like me logo Genes that share expression patterns with OR3A4P: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR3A4P Gene

Orthologs for OR3A4P Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR3A4P Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
 Mammalia Or3a4 46 Olfr399
  • chr11:74,053,825-74,054,757
Species where no ortholog for OR3A4P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR3A4P Gene

ENSEMBL:
Gene Tree for OR3A4P (if available)
TreeFam:
Gene Tree for OR3A4P (if available)

Paralogs for OR3A4P Gene

(434) SIMAP similar genes for OR3A4P Gene using alignment to 1 proteins:

  • OR3A4_HUMAN
genes like me logo Genes that share paralogs with OR3A4P: view

No data available for Paralogs for OR3A4P Gene

Variants for OR3A4P Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR3A4P Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs231677 - p.Arg237Lys
rs231678 - p.Ser193Ala
rs2855677 - p.Tyr181His
rs8076130 - p.Val300Ile
rs9903671 - p.Glu103Gln

Structural Variations from Database of Genomic Variants (DGV) for OR3A4P Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv2674191 CNV deletion 23128226
esv3639742 CNV loss 21293372
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457638 CNV gain 19166990
nsv457639 CNV gain 19166990
nsv470570 CNV gain 18288195
nsv520474 CNV loss 19592680
nsv574232 CNV gain 21841781
nsv574233 CNV gain 21841781
nsv574234 CNV gain 21841781
nsv574235 CNV loss 21841781

Additional Variant Information for OR3A4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR3A4P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Variation tolerance for OR3A4P Gene

Disorders for OR3A4P Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR3A4P Gene - From: LncRNADisease

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR3A4P

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with OR3A4P: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR3A4P Gene

Publications for OR3A4P Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  2. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G … Lancet D (Genomics 1996) 3 23
  3. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 3 4
  4. Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer. (PMID: 26863570) Guo X … Kuang Y (Oncotarget 2016) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4

ExternalLinks

View latest publications for OR3A4P gene in Mastermind

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