Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR3A3 Gene

Aliases for OR3A3 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 3 2 3 5
  • OR17-201 2 3 4
  • Olfactory Receptor OR17-22 3 4
  • Olfactory Receptor 17-201 3 4
  • Olfactory Receptor 3A3 3 4
  • Olfactory Receptor 3A6 3 4
  • Olfactory Receptor 3A7 3 4
  • Olfactory Receptor 3A8 3 4
  • OR17-137 2 3
  • OR17-16 2 3
  • OR3A8P 3 4
  • OR3A6 3 4
  • OR3A7 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 3, Subfamily A, Member 3 2
  • Olfactory Receptor, Family 3, Subfamily A, Member 6 3
  • Olfactory Receptor, Family 3, Subfamily A, Member 7 3
  • OR3A3 5

External Ids for OR3A3 Gene

Previous HGNC Symbols for OR3A3 Gene

  • OR3A6
  • OR3A7
  • OR3A8P

Previous GeneCards Identifiers for OR3A3 Gene

  • GC17P003638
  • GC17P003274
  • GC17P003530
  • GC17P003270
  • GC17P003323

Summaries for OR3A3 Gene

Entrez Gene Summary for OR3A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A3 Gene

OR3A3 (Olfactory Receptor Family 3 Subfamily A Member 3) is a Protein Coding gene. Diseases associated with OR3A3 include Aicardi Syndrome and Sturge-Weber Syndrome. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A2.

UniProtKB/Swiss-Prot Summary for OR3A3 Gene

Gene Wiki entry for OR3A3 Gene

Additional gene information for OR3A3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR3A3 Gene

Genomics for OR3A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR3A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003534 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 +124.5 124470 2.3 HNRNPL CTCF ZNF629 IKZF1 KDM1A MTA2 ZNF143 ZIC2 PKNOX1 MTA1 TRPV3 ANKFY1 RN7SL608P ZZEF1 OR3A3 P2RX5 RF00017-2232 lnc-SPATA22-1 SPATA22 MG828730-028
GH17J003386 Promoter/Enhancer 0.8 FANTOM5 Ensembl 11.6 -25.0 -24969 0.8 POLR2A EZH2 CTCF OR1R1P OR3A2 lnc-OR3A2-1 piR-57460-264 SPATA22 ASPA OR3A3 OR1E2 OR3A1 OR1E1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR3A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR3A3

Top Transcription factor binding sites by QIAGEN in the OR3A3 gene promoter:
  • AML1a
  • Chx10
  • GATA-2
  • IRF-2
  • MRF-2
  • Pax-2
  • Pax-2a
  • Pax-5
  • S8
  • TBP

Genomic Locations for OR3A3 Gene

Genomic Locations for OR3A3 Gene
chr17:3,411,370-3,424,070
(GRCh38/hg38)
Size:
12,701 bases
Orientation:
Plus strand
chr17:3,323,862-3,324,827
(GRCh37/hg19)
Size:
966 bases
Orientation:
Plus strand

Genomic View for OR3A3 Gene

Genes around OR3A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A3 Gene

Proteins for OR3A3 Gene

  • Protein details for OR3A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47888-OR3A3_HUMAN
    Recommended name:
    Olfactory receptor 3A3
    Protein Accession:
    P47888
    Secondary Accessions:
    • Q2VPE4
    • Q6IFM6
    • Q9P1Q4
    • Q9UBE7

    Protein attributes for OR3A3 Gene

    Size:
    321 amino acids
    Molecular mass:
    34963 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI08922.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR3A3 Gene

Post-translational modifications for OR3A3 Gene

  • Glycosylation at Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A3 Gene

Domains & Families for OR3A3 Gene

Gene Families for OR3A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR3A3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR3A3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor (O43878_HUMAN)
  • Olfactory receptor OR17-22 (OR3A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47888

UniProtKB/Swiss-Prot:

OR3A3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A3: view

Function for OR3A3 Gene

Molecular function for OR3A3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 3,subfamily A,member 3,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR3A3: view
genes like me logo Genes that share phenotypes with OR3A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR3A3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR3A3 Gene

Localization for OR3A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR3A3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR3A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR3A3 Gene

Pathways & Interactions for OR3A3 Gene

genes like me logo Genes that share pathways with OR3A3: view

Pathways by source for OR3A3 Gene

1 KEGG pathway for OR3A3 Gene

Interacting Proteins for OR3A3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000291231 P47888-OR3A3_HUMAN for OR3A3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR3A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8004088
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR3A3: view

No data available for SIGNOR curated interactions for OR3A3 Gene

Drugs & Compounds for OR3A3 Gene

No Compound Related Data Available

Transcripts for OR3A3 Gene

mRNA/cDNA for OR3A3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR3A3

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A3 Gene

No ASD Table

Relevant External Links for OR3A3 Gene

GeneLoc Exon Structure for
OR3A3

Expression for OR3A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR3A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR3A3

SOURCE GeneReport for Unigene cluster for OR3A3 Gene:

Hs.532689
genes like me logo Genes that share expression patterns with OR3A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR3A3 Gene

Orthologs for OR3A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC454428 30
  • 96.57 (n)
OR3A3 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC508980 30
  • 83.49 (n)
-- 31
  • 72 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia OR01E11 30
  • 83.12 (n)
-- 31
  • 71 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr411 30 17
  • 81.21 (n)
Olfr399 31
  • 72 (a)
ManyToMany
Or3a10 46 Olfr139
  • chr11:74,044,328-74,045,272
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 62 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 44 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
ManyToMany
Species where no ortholog for OR3A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR3A3 Gene

ENSEMBL:
Gene Tree for OR3A3 (if available)
TreeFam:
Gene Tree for OR3A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR3A3: view image

Paralogs for OR3A3 Gene

(458) SIMAP similar genes for OR3A3 Gene using alignment to 1 proteins:

  • OR3A3_HUMAN

Pseudogenes.org Pseudogenes for OR3A3 Gene

genes like me logo Genes that share paralogs with OR3A3: view

Variants for OR3A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR3A3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs12939997 - p.Met287Val
rs227787 - p.Lys317Glu
rs769432 - p.Leu132Phe
rs916039 - p.Trp158Leu

Additional dbSNP identifiers (rs#s) for OR3A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR3A3 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1060071 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897
nsv978351 CNV duplication 23825009

Variation tolerance for OR3A3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.38; 96.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR3A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR3A3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A3 Gene

Disorders for OR3A3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR3A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aicardi syndrome
  • aic
sturge-weber syndrome
  • sws
focal dermal hypoplasia
  • fdh
- elite association - COSMIC cancer census association via MalaCards
Search OR3A3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR3A3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with OR3A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR3A3 Gene

Publications for OR3A3 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4

Products for OR3A3 Gene

Sources for OR3A3 Gene