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Aliases for OR3A2 Gene

Aliases for OR3A2 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR17-14 3 4
  • Olfactory Receptor 17-228 3 4
  • OR17-228 3 4
  • OLFRA04 3 4
  • Olfactory Receptor, Family 3, Subfamily A, Member 2 2
  • Olfactory Receptor 3A2 3
  • OR17-14 3
  • OR228 3

External Ids for OR3A2 Gene

Previous GeneCards Identifiers for OR3A2 Gene

  • GC17U990068
  • GC17M003522
  • GC17M003132
  • GC17M003387
  • GC17M003128

Summaries for OR3A2 Gene

Entrez Gene Summary for OR3A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A2 Gene

OR3A2 (Olfactory Receptor Family 3 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OR3A3.

UniProtKB/Swiss-Prot for OR3A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR3A2 Gene

Additional gene information for OR3A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR3A2 Gene

Genomics for OR3A2 Gene

GeneHancer (GH) Regulatory Elements for OR3A2 Gene

Promoters and enhancers for OR3A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003386 Enhancer 0.4 FANTOM5 650.7 +0.0 5 0.4 POLR2A OR3A1 OR1R1P OR3A2 SPATA22 ASPA OR3A3 OR1E2
GH17J002958 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +425.9 425873 3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B ZNF48 GLIS2 DPH1 RAP1GAP2 ENSG00000263345 OR3A2 OR1G1 LOC101927911 GC17P002937
GH17J003750 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -364.8 -364838 1.2 HDGF PKNOX1 EBF1 MEF2B ZFHX2 IKZF1 ZFP36 NBN IKZF2 EGR2 HASPIN P2RX5 NCBP3 OR1E2 OR3A2 ATP2A3 ENSG00000262358 ITGAE
GH17J003130 Enhancer 0.2 FANTOM5 16.8 +255.5 255488 0.2 OR3A2 OR1A1 OR1E2 OR1G1 OR1A2 TRPV3 TRPV1 GC17P003146
GH17J002899 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +484.1 484139 5.3 RFX1 POLR2A RCOR1 BMI1 CHD2 OR3A2 GC17M002894 GC17M002899 RAP1GAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR3A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR3A2 gene promoter:
  • deltaCREB
  • CREB
  • PPAR-gamma2
  • PPAR-gamma1
  • GATA-2
  • S8
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for OR3A2 Gene

Genomic Locations for OR3A2 Gene
109,376 bases
Minus strand
1,085 bases
Minus strand

Genomic View for OR3A2 Gene

Genes around OR3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A2 Gene

Proteins for OR3A2 Gene

  • Protein details for OR3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 3A2
    Protein Accession:
    Secondary Accessions:
    • Q6IFM3
    • Q9P1Q3

    Protein attributes for OR3A2 Gene

    321 amino acids
    Molecular mass:
    35207 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A2 Gene

Post-translational modifications for OR3A2 Gene

  • Glycosylation at Asn14
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A2 Gene

No data available for DME Specific Peptides for OR3A2 Gene

Domains & Families for OR3A2 Gene

Gene Families for OR3A2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for OR3A2 Gene

Suggested Antigen Peptide Sequences for OR3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A2: view

Function for OR3A2 Gene

Molecular function for OR3A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR3A2 Gene

Gene Ontology (GO) - Molecular Function for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0038023 signaling receptor activity TAS 8921386
genes like me logo Genes that share ontologies with OR3A2: view
genes like me logo Genes that share phenotypes with OR3A2: view

Animal Model Products

miRNA for OR3A2 Gene

miRTarBase miRNAs that target OR3A2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR3A2 Gene

Localization for OR3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR3A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8921386
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR3A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR3A2 Gene

Pathways & Interactions for OR3A2 Gene

genes like me logo Genes that share pathways with OR3A2: view

Pathways by source for OR3A2 Gene

1 KEGG pathway for OR3A2 Gene

Interacting Proteins for OR3A2 Gene

Gene Ontology (GO) - Biological Process for OR3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8921386
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007606 sensory perception of chemical stimulus TAS 8921386
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR3A2: view

No data available for SIGNOR curated interactions for OR3A2 Gene

Drugs & Compounds for OR3A2 Gene

No Compound Related Data Available

Transcripts for OR3A2 Gene

mRNA/cDNA for OR3A2 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR3A2 Gene

Olfactory receptor, family 3, subfamily A, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A2 Gene

No ASD Table

Relevant External Links for OR3A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR3A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR3A2 Gene

This gene is overexpressed in Testis (x14.2).

NURSA nuclear receptor signaling pathways regulating expression of OR3A2 Gene:


SOURCE GeneReport for Unigene cluster for OR3A2 Gene:

genes like me logo Genes that share expression patterns with OR3A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR3A2 Gene

Orthologs for OR3A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC454427 33
  • 97.61 (n)
OR3A2 34
  • 96 (a)
(Bos Taurus)
Mammalia LOC509526 33
  • 86.62 (n)
-- 34
  • 85 (a)
-- 34
  • 85 (a)
-- 34
  • 82 (a)
(Canis familiaris)
Mammalia OR3A2 33
  • 83.54 (n)
OR12C10 34
  • 43 (a)
(Rattus norvegicus)
Mammalia Olr1512 33
  • 80.94 (n)
(Mus musculus)
Mammalia Olfr410 16 33
  • 79.59 (n)
Olfr411 34
  • 77 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
Species where no ortholog for OR3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR3A2 Gene

Gene Tree for OR3A2 (if available)
Gene Tree for OR3A2 (if available)
Evolutionary constrained regions (ECRs) for OR3A2: view image

Paralogs for OR3A2 Gene

Paralogs for OR3A2 Gene

(455) SIMAP similar genes for OR3A2 Gene using alignment to 1 proteins:

  • OR3A2_HUMAN Pseudogenes for OR3A2 Gene

genes like me logo Genes that share paralogs with OR3A2: view

Variants for OR3A2 Gene

Sequence variations from dbSNP and Humsavar for OR3A2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000004926 -- 3,369,805(-) CT/ genic_upstream_transcript_variant, intron_variant
rs1000037152 -- 3,372,840(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000052715 -- 3,364,223(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000056476 -- 3,338,182(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000098775 -- 3,378,123(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR3A2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457638 CNV gain 19166990
nsv457639 CNV gain 19166990
nsv470570 CNV gain 18288195
nsv574231 CNV gain 21841781
nsv574232 CNV gain 21841781
nsv574233 CNV gain 21841781
nsv574234 CNV gain 21841781
nsv827859 CNV gain 20364138
nsv960398 CNV duplication 23825009

Variation tolerance for OR3A2 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.13; 84.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR3A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A2 Gene

Disorders for OR3A2 Gene

Additional Disease Information for OR3A2

No disorders were found for OR3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR3A2 Gene

Publications for OR3A2 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G … Lancet D (Genomics 1996) 2 3 58
  4. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 3 4 58
  5. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (PMID: 23958962) Gelernter J … Farrer L (Molecular psychiatry 2014) 3 58

Products for OR3A2 Gene

Sources for OR3A2 Gene

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