Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR3A1 Gene

Aliases for OR3A1 Gene

  • Olfactory Receptor Family 3 Subfamily A Member 1 2 3 5
  • OLFRA03 2 3 4
  • OR17-40 2 3 4
  • Olfactory Receptor OR17-15 3 4
  • Olfactory Receptor 17-40 3 4
  • Olfactory Receptor 3A1 3 4
  • OR40 2 3
  • Olfactory Receptor Family 3 Subfamily A Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 3, Subfamily A, Member 1 2
  • Olfactory Receptor-Like Protein OR17-82 3
  • OR17-82 3
  • OR3A1 5

External Ids for OR3A1 Gene

Previous GeneCards Identifiers for OR3A1 Gene

  • GC17M003509
  • GC17M003536
  • GC17M003145
  • GC17M003401
  • GC17M003141
  • GC17M003194

Summaries for OR3A1 Gene

Entrez Gene Summary for OR3A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR3A1 Gene

OR3A1 (Olfactory Receptor Family 3 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with OR3A1 include Retinal Arteries, Tortuosity Of. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A2.

UniProtKB/Swiss-Prot Summary for OR3A1 Gene

Gene Wiki entry for OR3A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR3A1 Gene

Genomics for OR3A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR3A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003386 Promoter/Enhancer 0.7 FANTOM5 Ensembl 10.1 -87.2 -87211 0.8 POLR2A OR1R1P OR3A2 lnc-OR3A2-1 piR-57460-264 SPATA22 ASPA OR3A3 OR1E2 OR3A1 OR1E1
GH17J003176 Promoter 0.4 Ensembl 5.4 +122.3 122289 1 EGR2 LOC100288728 piR-33432-224 piR-45012-229 piR-37972-259 piR-49322-258 piR-46002-243 piR-57176-258 piR-55361-244 OR3A1 HSALNG0113951
GH17J003282 Enhancer 0.4 Ensembl 0.4 +16.4 16389 0.8 REST L3MBTL2 FOS piR-57460-263 OR1D3P piR-41525-259 OR3A1 OR1D4 OR3A2 lnc-OR3A2-1
GH17J003269 Enhancer 0.5 FANTOM5 Ensembl 0.3 +28.4 28389 2.4 ZNF26 piR-59452 SHPK METTL16 ENSG00000262903 RAP1GAP2 piR-41525-259 OR3A1 OR1D4
GH17J003260 Enhancer 0.4 Ensembl 0.3 +38.4 38389 0.4 ZNF521 ZNF366 ZNF512 OR1A2 OR1D3P OR1D4 OR3A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR3A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR3A1

Top Transcription factor binding sites by QIAGEN in the OR3A1 gene promoter:
  • CREB
  • deltaCREB
  • GATA-2
  • Nkx3-1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • PPAR-gamma1
  • PPAR-gamma2
  • S8

Genomic Locations for OR3A1 Gene

Latest Assembly
chr17:3,288,318-3,299,190
(GRCh38/hg38)
Size:
10,873 bases
Orientation:
Minus strand

Previous Assembly
chr17:3,194,311-3,201,654
(GRCh37/hg19 by Entrez Gene)
Size:
7,344 bases
Orientation:
Minus strand

chr17:3,194,929-3,195,876
(GRCh37/hg19 by Ensembl)
Size:
948 bases
Orientation:
Minus strand

Genomic View for OR3A1 Gene

Genes around OR3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR3A1 Gene

Proteins for OR3A1 Gene

  • Protein details for OR3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47881-OR3A1_HUMAN
    Recommended name:
    Olfactory receptor 3A1
    Protein Accession:
    P47881
    Secondary Accessions:
    • Q4VB06
    • Q6IFM4

    Protein attributes for OR3A1 Gene

    Size:
    315 amino acids
    Molecular mass:
    34609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR3A1 Gene

Post-translational modifications for OR3A1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR3A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR3A1 Gene

Domains & Families for OR3A1 Gene

Gene Families for OR3A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR3A1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR3A1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR17-15 (OR3A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P47881

UniProtKB/Swiss-Prot:

OR3A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR3A1: view

Function for OR3A1 Gene

Molecular function for OR3A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor gene family 3,subfamily A,member 1,G protein coupled receptor superfamily,with odorant ligand : helional and heliotropyl acetone

Phenotypes From GWAS Catalog for OR3A1 Gene

Gene Ontology (GO) - Molecular Function for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR3A1: view
genes like me logo Genes that share phenotypes with OR3A1: view

miRNA for OR3A1 Gene

miRTarBase miRNAs that target OR3A1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR3A1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR3A1 Gene

Localization for OR3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR3A1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR3A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR3A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR3A1 Gene

Pathways & Interactions for OR3A1 Gene

genes like me logo Genes that share pathways with OR3A1: view

Pathways by source for OR3A1 Gene

1 KEGG pathway for OR3A1 Gene

Interacting Proteins for OR3A1 Gene

Gene Ontology (GO) - Biological Process for OR3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,NAS 8921386
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR3A1: view

No data available for SIGNOR curated interactions for OR3A1 Gene

Drugs & Compounds for OR3A1 Gene

No Compound Related Data Available

Transcripts for OR3A1 Gene

mRNA/cDNA for OR3A1 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR3A1

Alternative Splicing Database (ASD) splice patterns (SP) for OR3A1 Gene

No ASD Table

Relevant External Links for OR3A1 Gene

GeneLoc Exon Structure for
OR3A1

Expression for OR3A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR3A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR3A1 Gene

This gene is overexpressed in Testis (x14.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR3A1

SOURCE GeneReport for Unigene cluster for OR3A1 Gene:

Hs.647410
genes like me logo Genes that share expression patterns with OR3A1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR3A1 Gene

Orthologs for OR3A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR3A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC468152 29
  • 98.52 (n)
OR3A1 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR3A1 29 30
  • 89.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC491212 29
  • 87.62 (n)
OR3A1 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or3a1 45 Olfr410 30
  • 85 (a)
OneToMany
Or3a1c 45 Olfr402 29 16 30
  • 83.28 (n)
OneToMany
Or3a1b 45 Olfr401 30
  • 81 (a)
OneToMany
Or3a15-ps 45 Olfr400-ps1
  • chr11:74,110,257-74,110,788
Or3a1d 45 Olfr411
  • chr11:74,346,638-74,347,582
Rat
(Rattus norvegicus)
Mammalia Olr1517 29
  • 84.87 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 66 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 46 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 37 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 39 (a)
ManyToMany
Species where no ortholog for OR3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR3A1 Gene

ENSEMBL:
Gene Tree for OR3A1 (if available)
TreeFam:
Gene Tree for OR3A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR3A1: view image
Alliance of Genome Resources:
Additional Orthologs for OR3A1

Paralogs for OR3A1 Gene

(456) SIMAP similar genes for OR3A1 Gene using alignment to 1 proteins:

  • OR3A1_HUMAN
genes like me logo Genes that share paralogs with OR3A1: view

Variants for OR3A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR3A1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs61734042 Benign: not provided 3,292,042(-) A/G
NM_002550.2(OR3A1):c.541T>C (p.Tyr181His)
MISSENSE
rs61734043 Benign: not provided 3,292,059(-) T/C
NM_002550.2(OR3A1):c.524A>G (p.Asn175Ser)
MISSENSE
rs7218125 Benign: not provided 3,292,309(-) T/A
NM_002550.2(OR3A1):c.274A>T (p.Lys92Ter)
NONSENSE
rs16952828 -- p.Ser78Gly
rs703903 -- p.Arg125Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR3A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR3A1 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3639741 CNV gain 21293372
esv3892949 CNV loss 25118596
esv3892950 CNV loss 25118596
nsv1060926 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv457638 CNV gain 19166990
nsv457639 CNV gain 19166990
nsv470570 CNV gain 18288195
nsv574232 CNV gain 21841781
nsv574233 CNV gain 21841781
nsv574234 CNV gain 21841781
nsv574235 CNV loss 21841781
nsv827859 CNV gain 20364138

Variation tolerance for OR3A1 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR3A1
Leiden Open Variation Database (LOVD)
OR3A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR3A1 Gene

Disorders for OR3A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR3A1 Gene - From: COP

Disorder Aliases PubMed IDs
retinal arteries, tortuosity of
  • rator
- elite association - COSMIC cancer census association via MalaCards
Search OR3A1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR3A1

genes like me logo Genes that share disorders with OR3A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR3A1 Gene

Publications for OR3A1 Gene

  1. Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. (PMID: 8921386) Glusman G … Lancet D (Genomics 1996) 2 3 4
  2. Olfactory receptor-encoding genes and pseudogenes are expressed in humans. (PMID: 8647456) Crowe ML … Connerton IF (Gene 1996) 2 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G … Lancet D (Genomics 2000) 3 4

Products for OR3A1 Gene

Sources for OR3A1 Gene