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Aliases for OR2Z1 Gene

Aliases for OR2Z1 Gene

  • Olfactory Receptor Family 2 Subfamily Z Member 1 2 3 5
  • Olfactory Receptor, Family 2, Subfamily Z, Member 2 2 3
  • Olfactory Receptor OR19-4 3 4
  • Olfactory Receptor 2Z1 3 4
  • Olfactory Receptor 2Z2 3 4
  • OR2Z2 3 4
  • Olfactory Receptor, Family 2, Subfamily Z, Member 1 2
  • OR19-4 3

External Ids for OR2Z1 Gene

Previous HGNC Symbols for OR2Z1 Gene

  • OR2Z2

Previous GeneCards Identifiers for OR2Z1 Gene

  • GC19U990261
  • GC19P008703
  • GC19P008841

Summaries for OR2Z1 Gene

Entrez Gene Summary for OR2Z1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2Z1 Gene

OR2Z1 (Olfactory Receptor Family 2 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2V1.

UniProtKB/Swiss-Prot for OR2Z1 Gene

Gene Wiki entry for OR2Z1 Gene

Additional gene information for OR2Z1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2Z1 Gene

Genomics for OR2Z1 Gene

GeneHancer (GH) Regulatory Elements for OR2Z1 Gene

Promoters and enhancers for OR2Z1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008701 Enhancer 0.5 ENCODE 0.4 -19.5 -19515 1.1 ZFHX2 VEZF1 MYC MAX EGR2 CBFA2T3 ACTL9 OR2Z1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR2Z1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR2Z1 gene promoter:
  • aMEF-2
  • AML1a
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • IRF-2
  • MEF-2A
  • MyoD
  • Pax-5

Genomic Locations for OR2Z1 Gene

Genomic Locations for OR2Z1 Gene
10,527 bases
Plus strand
1,056 bases
Plus strand

Genomic View for OR2Z1 Gene

Genes around OR2Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2Z1 Gene

Proteins for OR2Z1 Gene

  • Protein details for OR2Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 2Z1
    Protein Accession:
    Secondary Accessions:
    • B9EH50
    • Q6IFK0
    • Q96R25

    Protein attributes for OR2Z1 Gene

    314 amino acids
    Molecular mass:
    34444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2Z1 Gene

Post-translational modifications for OR2Z1 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2Z1 Gene

Domains & Families for OR2Z1 Gene

Gene Families for OR2Z1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2Z1 Gene

Suggested Antigen Peptide Sequences for OR2Z1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-4 (OR2Z1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2Z1: view

Function for OR2Z1 Gene

Molecular function for OR2Z1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR2Z1 Gene

Gene Ontology (GO) - Molecular Function for OR2Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR2Z1: view
genes like me logo Genes that share phenotypes with OR2Z1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2Z1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2Z1 Gene

Localization for OR2Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2Z1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2Z1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR2Z1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2Z1 Gene

Pathways & Interactions for OR2Z1 Gene

genes like me logo Genes that share pathways with OR2Z1: view

Pathways by source for OR2Z1 Gene

Interacting Proteins for OR2Z1 Gene

Gene Ontology (GO) - Biological Process for OR2Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2Z1: view

No data available for SIGNOR curated interactions for OR2Z1 Gene

Drugs & Compounds for OR2Z1 Gene

No Compound Related Data Available

Transcripts for OR2Z1 Gene

mRNA/cDNA for OR2Z1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR2Z1 Gene

Olfactory receptor, family 2, subfamily Z, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR2Z1

Alternative Splicing Database (ASD) splice patterns (SP) for OR2Z1 Gene

No ASD Table

Relevant External Links for OR2Z1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR2Z1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2Z1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2Z1 Gene:


SOURCE GeneReport for Unigene cluster for OR2Z1 Gene:

genes like me logo Genes that share expression patterns with OR2Z1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2Z1 Gene

Orthologs for OR2Z1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2Z1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR2Z1 35 34
  • 99.15 (n)
(Canis familiaris)
Mammalia OR2Z1 35 34
  • 86.5 (n)
(Bos Taurus)
Mammalia OR2Z1 35 34
  • 85.17 (n)
(Rattus norvegicus)
Mammalia Olr1096 34
  • 77.1 (n)
(Mus musculus)
Mammalia Or2z8 51 Olfr372 34
  • 74.28 (n)
Or2z9 51 Olfr373 17 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia OR2Z1 35
  • 55 (a)
(Monodelphis domestica)
Mammalia OR2Z1 35
  • 53 (a)
Species where no ortholog for OR2Z1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2Z1 Gene

Gene Tree for OR2Z1 (if available)
Gene Tree for OR2Z1 (if available)
Evolutionary constrained regions (ECRs) for OR2Z1: view image

Paralogs for OR2Z1 Gene

(445) SIMAP similar genes for OR2Z1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2Z1: view

Variants for OR2Z1 Gene

Sequence variations from dbSNP and Humsavar for OR2Z1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193921073 uncertain-significance, Malignant tumor of prostate 8,731,906(+) G/T coding_sequence_variant, missense_variant
rs1001754613 -- 8,729,653(+) C/A/G/T upstream_transcript_variant
rs1002212392 -- 8,729,387(+) C/T upstream_transcript_variant
rs1002812564 -- 8,730,629(+) A/C upstream_transcript_variant
rs1003764937 -- 8,732,144(+) C/A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR2Z1 Gene

Variant ID Type Subtype PubMed ID
dgv3425n100 CNV gain 25217958
dgv571n67 CNV gain 20364138
esv2762024 CNV gain 21179565
nsv1057425 CNV gain 25217958
nsv1059126 CNV gain 25217958
nsv1065961 CNV gain 25217958
nsv2402 CNV deletion 18451855
nsv469648 CNV gain+loss 16826518
nsv469747 CNV gain+loss 16826518
nsv471705 CNV gain+loss 15918152
nsv833735 CNV gain+loss 17160897
nsv833737 CNV gain+loss 17160897
nsv962998 CNV duplication 23825009

Variation tolerance for OR2Z1 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR2Z1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2Z1 Gene

Disorders for OR2Z1 Gene

Additional Disease Information for OR2Z1

No disorders were found for OR2Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2Z1 Gene

Publications for OR2Z1 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for OR2Z1 Gene

Sources for OR2Z1 Gene

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